Embedded Files
2020 -
2020 -
341. Transmembrane PhoxID: Photoproximity labelling across the plasma membrane in vivo
F. Y. Tanimura Valor, M. Takato, A. Araki, S. Sakamoto, T. Tamura*, I. Hamachi*
Nature Communications, accepted in principle
340. Supramolecular Morphological Transition Driven by Nonequilibrium Break-and-Build Self-Organisation
R. Kubota*, Y. Ikuta, S. Torigoe, N. Kanazawa, I. Hamachi*
Nature Communications, just accepted doi: 10.26434/chemrxiv-2025-73bg1 (Preprint)
339. Bioorthogonal chemical labeling of endogenous receptors in the live mouse brain
H. Nonaka*, I. Hamachi*
Methods in Enzymology, 731, 317-334 (2026) doi: 10.1016/bs.mie.2026.05.018
338. Click Chemistry for Protein Modification in Live Cells and In Vivo
S. Sakamoto, I. Hamachi*
Topics in Heterocyclic Chemistry, Electronic ISSN 1861-9290 (2026) doi: 10.1007/7081_2025_102
337. Organelle-selective click chemistry for monitoring fatty acid metabolism at the subcellular level
T. Tamura*, S. Kawamoto, I. Hamachi
Methods in Enzymology, 727, 355-371 (2026) doi: 10.1016/bs.mie.2026.01.016
336. Lysine-reactive tag system for cell-surface protein labeling via N-acyl-N-alkyl sulfonamide chemistry
V. Thimaradka, T. Tamura*, I. Hamachi*
Bioorganic & Medicinal Chemistry Letters, 131: 130470 (2026) doi: 10.1016/j.bmcl.2025.130470
335. Ligand-Directed Self-Assembling Chimeras for Targeted Protein O-GlcNAcylation
Z. Guo, T. Xu, K. S. Khan, S. Scheeff, Y. Qin, S. Yu, R. Lo, Y. Li, Y. Xie, B. Ma, Y. Huang, H. Y. Yip, C. Y. Chung, T. Tamura, I. Hamachi, B. W. Ng*
ACS Chemical Biology, 20, 12, 2907-2916 (2025) doi: 10.1021/acschembio.5c00684 Open Access
334. Proximity effects leveraged in ligand-directed chemical labeling of natural proteins under live conditions
I. Hamachi*, T. Tamura, H. Nonaka
Accounts of Chemical Research, 58, 24, 3592-3602 (2025) doi: 10.1021/acs.accounts.5c00646
333. A chemogenetic strategy for inhibiting G protein-coupled receptor activity using metal coordination
T. Doura, T. Sugawara, H. Inoue, M. Tsujikawa, Y. Michibata, I. Hamachi, S. Kiyonaka*
Chemistry Letters, 54, 8, upaf152 (2025) doi: 10.1093/chemle/upaf152 Open Access
332. N-oxide-driven heme-activatable biomolecule labeling for visualization of labile heme in living cells and mouse brain
R. Kakiuchi, T. Fukaya, S. Tamakoshi, S. Tsuji, H. Fujimori, M. Shimazawa, T. Tamura, I. Hamachi, T. Ochi, H. Matsunaga, H. Takeyama, H. Nagasawa, T. Hirayama*
Journal of the American Chemical Society, 147, 31, 27484-27493 (2025) doi: 10.1021/jacs.5c04990
331. Zinc Conditional Proteomics Using Zinc-responsive Protein Labelling Reagent and Recent Examples of Expansion to Other Biometals
T. Tamura*, I. Hamachi*
Zinc in Biology, 2, 24-39 (2025) doi: 10.1039/9781837676583-00024
330. Subcellular analysis of fatty acid metabolism using organelle-selective click chemistry
T. Kimura, S. Kawamoto, A. Fujisawa, M. Yoshida, Y. Shen, M. Tsuchiya, T. Tamura*, I. Hamachi*
Journal of the American Chemical Society, 147, 26, 22284-22289 (2025) doi: 10.1021/jacs.5c02871
329. Recent advances in proximity labeling for chemical proteomics: paving the way for in vivo applications
F. Y. Tanimura Valor, T. Tamura, I. Hamachi*
Current Opinion in Chemical Biology, 87, 102620 (2025) doi: 10.1016/j.cbpa.2025.102620 Open Access
328. Rapid and reversible fluorescent probe enables repeated snapshot imaging of AMPA receptors during synaptic plasticity
K. Soga, T. Fujiwara, M. Nakagawa, A. Shibata, H. Adriel, K. Yatsuzuka, W. Kakegawa, M. Yuzaki, I. Hamachi, E. Nango*, S. Kiyonaka*
Science Advances, 11, 23, 2375-2548 (2025) doi: 10.1126/sciadv.adt6683 Open Access
327. In-brain synthesis of receptor-based protease sensors by coupling ligand-directed chemistry and click chemistry
S. Sakamoto, K. Shiraiwa, M. Wang, M. Ishikawa, H. Nonaka*, I. Hamachi*
Nature Synthesis, 4, 1128-1140 (2025) doi: 10.1038/s44160-025-00815-6 Open Access
326. Intratumour oxidative hotspots provide a niche for cancer cell dissemination
Y. Ueda, S. Kiyonaka*, L. M. Selfors, K. Inoue, H. Harada, T. Doura, K. Onuma, M. Uchiyama, R. Kurogi, Y. Yamada, J. H. Sun, R. Sakaguchi, Y. Tado, H. Omatsu, H. Suzuki, M. Aoun, T. Nakayama, T. Kajimoto, T. Yano, R. Holmdahl, I. Hamachi, M. Inoue, Y. Mori*, N. Takahashi*
Nature Cell Biology, 27, 530-543 (2025) doi: 10.1038/s41556-025-01617-w
325. Profiling proteins involved in peroxynitrite homeostasis using ROS/RNS conditional proteomics
H. Zhu*, H. Uno, K. Matsuba, I. Hamachi*
Journal of the American Chemical Society, 147, 9, 7305-7316 (2025) doi: 10.1021/jacs.4c14060
324. A Protein Cleavage Platform Based on Selective Formylation at Cysteine Residues
N. Zenmyo, Y. Matsumoto, A. Yasuda, S. Uchinomiya, N. Shindo, K. Sasaki-Tabata, E. Mishiro-Sato, T. Tamura, I. Hamachi, A. Ojida*
Journal of the American Chemical Society, 147, 4, 3080-3091(2025) doi: 10.1021/jacs.4c10991
323. Chromosomal domain formation by archaeal SMC, a roadblock protein, and DNA structure
K. Yamaura, N. Takemata*, M. Kariya, A. Osaka, S. Ishino, M. Yamauchi, T. Tamura, I. Hamachi, S. Takada, Y. Ishino, H. Atomi*
Nature Communications, 16: 1312 (2025) doi: 10.1038/s41467-025-56197-y Open Access
322. Conversion of silent synapses to AMPA receptor-mediated functional synapses in human cortical organoids
M. Nishimura, T. Kodera, S. Adachi, A. Y. Sato, R. F. Takeuchi, H. Nonaka, I. Hamachi, F. Osakada*
Neuroscience Research, 212, 20-30 (2025) doi: 10.1016/j.neures.2024.12.008 Open Access
321. Thoughts for the future
L. M. Alkhalaf, C. Arrowsmith, E. P. Balskus, G. Bergamini, R. Bhandari, C. J. Chang, P. Chen, X. Chen, A. Ciulli, J. A. Cricco, B. G. Davis, M. Delbianco, N. Dudareva, E. Dueber, F. Ferguson, P. O. Giuseppe, I. Hamachi, M. C. Hammond, S. K. Hatzios, W. D. Heo, J. P. Janet, S. S. Kamat, S. Knapp, Y. Krishnan, K. Lang, L. Laraia, R. B. Leveson-Gower, X. D. Li, D. R. Liu, M. Liu, N. London, N. Mahanta, C. Mayor-Ruiz, T. Muir, M. T. Murakami, H. Rhee, M. Robers, A. Satz, B. A. Schulman, B. Shen, B. Shoichet, E. Strauss, T. Suzuki, P. Tiwary, H. Waldmann, T. R. Ward, A. Weeks, E. Weerapana, G. Winter
Nature Chemical Biology, 21, 6-15 (2025) doi:10.1038/s41589-024-01802-2
320. Selective Labeling of Phosphatidylcholine to Track Their Translocation Between Organelles in Living Cells
T. Tamura*, I. Hamachi*
Intracellular Lipid Transport, 1, 1-11 (2025) eBook ISBN 978-1-0716-4318-1
319. Targeted covalent modification strategies for drugging the undruggable targets
T. Tamura*, M. Kawano, I. Hamachi*
Chemical Reviews, 125, 2, 1191-1253 (2025) doi: 10.1021/acs.chemrev.4c00745
318. N-acyl-N-alkyl/aryl sulfonamide chemistry assisted by proximity for modification and covalent inhibition of endogenous proteins in living systems
T. Tamura*, I. Hamachi*
Accounts of Chemical Research, 58, 1, 87-100 (2025) doi: 10.1021/acs.accounts.4c00628
317. Photoproximity labeling of endogenous receptors in the live mouse brain in minutes
M. Takato, S. Sakamoto, H. Nonaka, F. Y. Tanimura Valor, T. Tamura*, I. Hamachi*
Nature Chemical Biology, 21, 109-119 (2025) doi: 10.1038/s41589-024-01692-4
316. P2Y12 receptor ligands enable design of fluorescent imaging probes for microglia
H. Nonaka*, M. Wang, I. Hamachi*
Chemistry Letters, 53, 10, upae185 (2024) doi: 10.1093/chemle/upae185 Open Access
315. Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging
T. Mino, H. Nonaka, I. Hamachi*
Current Opinion in Chemical Biology, 81, 102474 (2024) doi: 10.1016/j.cbpa.2024.102474
314. Protein-labeling reagents selectively activated by copper(I)
R. Cheng, Y. Nishikawa, T. Wagatsuma, T. Kambe, Y. Tanaka, Y. Ogra, T. Tamura*, I. Hamachi*
ACS Chemical Biology, 19, 6, 1222-1228 (2024) doi: 10.1021/acschembio.4c00011
313. Post-click labeling enables highly accurate single cell analyses of glucose uptake ex vivo and in vivo
M. Tsuchiya*, N. Tachibana, I. Hamachi*
Communications Biology, 7: 459 (2024) doi: 10.1038/s42003-024-06164-y Open Access
312. Tyrosinase-based proximity labeling in living cells and in vivo
H. Zhu*, J. H. Oh, Y. Matsuda, T. Mino, M. Ishikawa, H. Nakamura, M. Tsujikawa, H. Nonaka, I. Hamachi*
Journal of the American Chemical Society, 146,11,7515-7523 (2024) doi: 10.1021/jacs.3c13183
311. Emergence of dynamic instability by hybridizing synthetic self-assembled dipeptide fibers with surfactant micelles
S. Torigoe, K. Nagao, R. Kubota*, I. Hamachi*
Journal of the American Chemical Society, 146, 9, 5799–5805 (2024) doi: 10.1021/jacs.3c14565
310. Bioorthogonal chemical labeling of endogenous neurotransmitter receptors in living mouse brains
H. Nonaka, S. Sakamoto, K. Shiraiwa, M. Ishikawa, T. Tamura, K. Okuno, T. Kondo, S. Kiyonaka, E. A. Susaki, C. Shimizu, H. R. Ueda, W. Kakegawa, I. Arai, M. Yuzaki, I. Hamachi*
Proceeding of National Academy of Science of USA, 121, 6: 2313887121 (2024) doi: 10.1073/pnas.2313887121 Open Access
309. Naturally occurring quercetin and myricetin as potent inhibitors for Äb01 human ectonucleotide pyrophosphatase/phosphodiesterase 1
P. Duangiad, B. Nutho, T. Chaijarasphong, N. P. Morales, T. Pongtharangkul, I. Hamachi, A. Ojida, J. Wongkongkatep*
Scientific Reports, 14: 125 (2024) doi: 10.1038/s41598-023-50590-7 Open Access
308. Lysine-reactive N-acyl-N-aryl sulfonamide warheads: Improved reaction properties and application in the covalent inhibition of an ibrutinib-resistant BTK mutant
M. Kawano, S. Murakawa, K. Higashiguchi, K. Matsuda, T. Tamura*, I. Hamachi*
Journal of the American Chemical Society, 145, 48, 26202–26212 (2023) doi: 10.1021/jacs.3c08740
307. Cell-Like Synthetic Supramolecular Soft Materials Realized in Multicomponent, Non-/Out-of-Equilibrium Dynamic Systems
R. Kubota*, I. Hamachi*
Advanced Science, 2806830 (2023) doi:10.1002/advs.202306830 Open Access
306. Protocol to visualize the distribution of exogenously administered small molecules in the mouse brain
T. Mino, H. Nonaka, S. Sakamoto, J. H. Oh, I. Hamachi*
STAR Protocols, 4,3,102555(2023) doi:10.1016/j.xpro.2023.102555 Open Access
305. Visualizing formation and dynamics of a three-dimensional sponge-like network of a coacervate in real time
R. Kubota*, T. Hiroi, Y. Ikuta, Y. Liu, I. Hamachi*
Journal of the American Chemical Society, 145, 33, 18316-18328 (2023) doi:10.1021/jacs.3c03793
304. Flow cytometric analysis of phosphatidylcholine metabolism using organelle-selective click labeling
M. Tsuchiya*, N. Tachibana, I. Hamachi*
STAR Protocols, 4,3,102525(2023) doi:10.1016/j.xpro.2023.102525 Open Access
303. Coronaridine congeners induce sedative and anxiolytic-like activity in naive and stressed/anxious mice by allosteric mechanisms involving increased GABAA receptor affinity for GABA
H. R. Arias, P. D. Deurwaerdère, P. Scholze, S. Sakamoto, I. Hamachi, G. D. Giovanni, A. Chagraoui*
European Journal of Pharmacology, 953: 175854 (2023) doi: 10.1016/j.ejphar.2023.175854
302. Endogenous cell-surface receptor modification by metal chelation-assisted pyridinium oxime catalyst
V. Thimaradka, H. Utsunomiya, T. Tamura*, I. Hamachi*
Organic Letters, 25, 12, 2118-2122 (2023) doi:10.1021/acs.orglett.3c00541
301. Four distinct network patterns of supramolecular/polymer composite hydrogels controlled by formation kinetics and interfiber interactions
K. Nakamura, R. Kubota*, T. Aoyama, K. Urayama, I. Hamachi*
Nature Communications, 14: 1696 (2023) doi:10.1038/s41467-023-37412-0 Open Access
300. Organelle-selective click labeling coupled with flow cytometry allows pooled CRISPR screening of genes involved in phosphatidylcholine metabolism
M. Tsuchiya, N. Tachibana, K. Nagao, T. Tamura*, I. Hamachi*
Cell Metabolism, 35, 6, 1072-1083 (2023) doi:10.1016/j.cmet.2023.02.014 Open Access
299. Ligand-directed chemistry for protein labeling for affinity-based protein analysis
S. Sakamoto, I. Hamachi*
Israel Journal of Chemistry, e202200077 (2023) doi: 10.1002/ijch.202200077
298. Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes
H. Nonaka, T. Mino, S. Sakamoto, J. H. Oh, Y. Watanabe, M. Ishikawa, A. Tsushima, K. Amaike, S. Kiyonaka, T. Tamura, A. R. Aricescu, W. Kakegawa, E. Miura, M. Yuzaki, I. Hamachi*
Chem, 9, 2, 523-540 (2023) doi:10.1016/j.chempr.2022.11.005 Open Access
297. Chemical, Pharmacological, and Structural Characterization of Novel Acrylamide-Derived Modulators of the GABAA Receptor
H. R. Arias*, S. R. Pierce, A. L. Germann, S. Q. Xu, M. O. Ortells, S. Sakamoto, D. Manetti, M. Novella R., I. Hamachi, G. Akk
Molecular Pharmacology, 104, 3, 115-131 (2023) doi: 10.1124/molpharm.123.000692 Open Access
296. Recent progress of subcellular-compartment-focused chemical proteomics
L. Wang, H. Nonaka, I. Hamachi
Advances in Chemical Proteomics, 217-247 (2022) doi: 10.1016/B978-0-12-821433-6.00006-4
295. Fluorescence identification of arthropathic calcium pyrophosphate single crystals using alizarin red S and a xanthene dipicolylamine ZnII complex
W. Srinarawat, R. Hemstapat, T. Tawonsawatruk, N. Patikarnmonthon, I. Hamachi, A. Ojida and J. Wongkongkatep*
Analyst, 147, 21, 4910-4918 (2022) doi:10.1039/D2AN01257J
294. Modulation of the mammalian GABAA receptor by type I and type II positive allosteric modulators of the α7 nicotinic acetylcholine receptor
H. R. Arias, A. L. Germann, S. R. Pierce, S. Sakamoto, M. O. Ortells, I. Hamachi, G. Akk*
British Journal of Pharmacology, 179, 24, 5323-5337 (2022) doi:10.1111/bph.15948 Open Access
293. Light-induced stabilization of microtubules by photo-crosslinking of Tau-derived peptide
S. Watari, H. Inaba*, T. Tamura, A. Md. R. Kabir, A. Kakugo, K. Sada, I. Hamachi, K. Matsuura*
Chemical Communications , 58, 9190 - 9193 (2022) doi:10.1039/D2CC01890J Open Access
292. Temporal stimulus patterns drive differentiation of a synthetic dipeptide-based coacervate
R. Kubota*, S. Torigoe, I. Hamachi*
Journal of the American Chemical Society , 144, 33, 15155-15164 (2022) doi:10.1021/jacs.2c05101
291. Chemical biology tools for imaging-based analysis of organelle membranes and lipids
T. Tamura*, I. Hamachi*
Current Opinion in Chemical Biology , 70: 102182 (2022) doi: 10.1016/j.cbpa.2022.102182
290. Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue
K. Ojima, W. Kakegawa, T. Yamasaki, Y. Miura, M. Itoh, Y. Michibata, R. Kubota, T. Doura, E. Miura, H. Nonaka, S. Mizuno, S. Takahashi, M. Yuzaki*, I. Hamachi*, S. Kiyonaka*
Nature Communications , 13, 3167 (2022) doi:10.1101/2021.10.01.462737 Open Access
289. Orthogonal activation of metabotropic glutamate receptor using coordination chemogenetics
A. Senoo, Y. Yamada, K. Ojima, T. Doura, I. Hamachi, S. Kiyonaka*
Frontiers in Chemistry , 9, 825669 (2022) doi:10.3389/fchem.2021.825669 Open Access
288. Extracellular ATP limits homeostatic T cell migration within lymph nodes
D. Kobayashi, Y. Sugiura, E. Umemoto, A. Takeda, H. Ueta, H. Hayasaka, S. Matsuzaki, T. Katakai, M. Suematsu, I. Hamachi, G. G Yegutkin, M. Salmi, S. Jalkanen, M. Miyasaka*
Frontiers in Immunology, 12 (2021) doi:10.3389/fimmu.2021.786595 Open Access
287. Photo-triggered spatially controlled out-of-equilibrium patterns of peptide nanofibers in a self-sorting double network hydrogel
K. Nakamura, W. Tanaka, K. Sada, R. Kubota, T. Aoyama, K. Urayama, I. Hamachi*
Journal of the American Chemical Society, 143, 46, 19532–19541(2021) doi:10.1021/jacs.1c09172
286. Organelle-selective labeling of choline-containing phospholipids(CPLs) and real-time imaging in living cells
M. Tsuchiya, T. Tamura, I. Hamachi*
Current Protocols , e105, Volume 1 (2021) doi: 10.1002/cpz1.105
285. Recent applications of N-acyl imidazole chemistry in chemical biology
T. Mino, S. Sakamoto, I. Hamachi*
Bioscience, Biotechnology, and Biochemistry , 85, 1, 53-60 (2021) doi:10.1093/bbb/zbaa026 Open Access
284. Voices of chemical biology
B. Davis, K. Backus, G. Winter, R. Chica, D. Li, S. Lee, C. He, A. Weeks, C. Overall, S. Hagihara, B. Thuronyi, S. Kamat, L. Chen, R. HurtadoGuerrero, S. Yao, L. Mahal, C. Voigt, C. Woo, E. Strauss, K. Kikuchi, T. Dore, S. Radford, X. Li, W. Heo, G. S. Furga, T. Deans, V. Belousov, M. Matthews, C. Jackson, S. Malek, H. Waldmann, A. Rising, M. Jewett, D. Stamou, E. Parker, M. Murakami, K. Polizzi, I. Hamachi, T. Erb, C. Joo, M. Uesugi, R. Prinjha, G. Rechavi, R. Solano, B. Schulman, Y. David, R. Oslund
Nature Chemical Biology , 17, 1-4 (2021) doi:10.1038/s41589-020-00714-1
283. Microscopic Imaging Techniques for Molecular Assemblies: Electron, Atomic Force, and Confocal Microscopies
R. Kubota, W. Tanaka, I. Hamachi*
Chemical Reviews, 121, 22, 14281-14347 (2021) doi:10.1021/acs.chemrev.0c01334
282. Enhanced Suppression of a Protein–Protein Interaction in Cells Using Small-Molecule Covalent Inhibitors Based on an N-Acyl-N-alkyl Sulfonamide Warhead
T. Ueda, T. Tamura, M. Kawano, K. Shiono, F. Hobor, A. J. Wilson, and I. Hamachi*
Journal of the American Chemical Society , 143, 12, 4766–4774(2021) doi.org/10.1021/jacs.1c00703
281. Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking
K. Ojima, K. Shiraiwa, T. Doura, M. Takato, K. Komatsu, M. Yuzaki, I. Hamachi*, S. Kiyonaka*
Nature Communications , 12:831 (2021) doi:10.1038/s41467-021-21082-x Open Access
280. Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent
V. Thimaradka, J. H. Oh, C. Heroven, A. R. Aricescu, M. Yuzaki, T. Tamura*, I. Hamachi*
Bioorganic & Medicinal Chemistry, , 30, 115947(2021) doi:10.1016/j.bmc.2020.115947 Open Access
279. Fluorescence imaging of drug target proteins using chemical probes
H. Zhu, I. Hamachi*
Journal of Pharmaceutical Analysis , 10, 5, 426-433 (2020) doi:10.1016/j.jpha.2020.05.013 Open Access
278. Chemical Tools for Endogenous Protein Labeling and Profiling
K. Shiraiwa, R. Cheng, H. Nonaka, T. Tamura, and I. Hamachi*
Cell Chemical Biology , 27, 8, 970-985(2020) doi:10.1016/j.chembio|.2020.06016 Open Access
277. In Situ Real-time Confocal Imaging of a Self-assembling Peptide-grafted Polymer Showing pH-responsive Hydrogelation
R. Kubota, S. Torigoe, S. Liu, & I. Hamachi*
Chemistry Letters , 49, 11, 1319-1323(2020) doi:10.1246/cl.200513
276. Organelle membrane-specific chemical labeling and dynamic imaging in living cells
T. Tamura, A. Fujisawa, M. Tsuchiya, Y. Shen, K. Nagao, S. Kawano, Y. Tamura, T. Endo, M. Umeda & I. Hamachi*
Nature Chemical Biology , 16, 12, 1361-1367(2020) doi:10.1038/s41589-020-00651-z
275. Imaging and profiling of proteins under oxidative conditions in cells and tissues by hydrogen-peroxide-responsive labeling
H. Zhu, T. Tamura, A. Fujisawa, Y. Nishikawa, R. Cheng, M. Takato, and I. Hamachi*
Journal of the American Chemical Society , 142, 37, 15711–15721(2020) doi:10.1021/jacs.0c02547
274. Control of seed formation allows two distinct self-sorting patterns of supramolecular nanofibers
R. Kubota, K. Nagao, W. Tanaka, R. Matumura, T. Aoyama, K. Urayama and I. Hamachi*
Nature Communications , 11: 4100(2020) doi:10.1038/s41467-020-17984-x Open Access
273. Activity-Based Sensing with a Metal-Directed Acyl Imidazole Strategy Reveals Cell Type-Dependent Pools of Labile Brain Copper
S. Lee, Y. S. C. Chung, P. Liu, L. Craciun, Y. Nishikawa, K. Bruemmer, I. Hamachi, K. Saijo, E. Miller, C. Chang*
Journal of the American Chemical Society , 142, 35, 14993–15003(2020) doi:10.1021/jacs.0c05727
272. Protein-Responsive Protein-Release of Supramolecular/polymer Hydrogel Composite Integrating Enzyme Activation Systems
H. Shigemitsu, R. Kubota, K. Nakamura, T. Matsuzaki, S. Minami, T. Aoyama, K. Urayama and I. Hamachi*
Nature Communications , 11: 3859(2020) doi:10.1038/s41467-020-17698-0 Open Access
271. Force generation by a propagating wave of supramolecular nanofibers
R. Kubota, M. Makuta, R. Suzuki, M. Ichikawa, M. Tanaka and I. Hamachi*
Nature Communications, 11: 3541(2020) doi:10.1038/s41467-020-17394-z Open Access
270. Fluorescence determination of soluble pyrophosphate levels in synovial fluid as a marker of pseudogout using middle point of quantification concept and molecular sensor
N. Yongwattana, N. Mekjinda, W. Thepsing, S. Ounsuk, P. Wongkongkatep, T. Tawonsawatruk, I. Hamachi, A. Ojida, J. Wongkongkatep*
Science Asia , 46, 36-42 (2020) doi:10.2306/scienceasia1513-1874.2020.S005 Open Access
269. Fluorescence Differentiation of ATP-Related Multiple Enzymatic Activities in Synovial Fluid as a Marker of Calcium Pyrophosphate Deposition Disease Using Kyoto Green
N. Yongwattana, N. Mekjinda,T. Tawonsawatruk, I. Hamachi, A. Ojida and J. Wongkongkatep*
molecules, 25, 1116 (2020) doi:10.3390/molecules25051116 Open Access
268. Screening of protein-ligand interactions under crude conditions by native mass spectrometry
K. Takano, S. Arai, S. Sakamoto, H. Ushijima, T. Ikegami, K. Saikusa, T. Konuma, I. Hamachi, S. Akashi*
Analytical and Bioanalytical Chemistry , 412, 4037-4043 (2020) doi:10.1007/s00216-020-02649-x
267. Masking Phosphate with Rare-Earth Elements Enables Selective Detection of Arsenate by Dipycolylamine-ZnII Chemosensor
N. Mekjinda, S. Phunnarungsi, V. Ruangpornvisuti, R. Ritchie, I. Hamachi, A. Ojida*, J. Wongkongkatep*
Scientific Reports , 10:2656 (2020) doi:10.1038/s41598-020-59585-0 Open Access
266. Development of a Photoactivatable Proximity Labeling Method for the Identification of Nuclear Proteins
T. Tamura*, M. Takato, K. Shiono, I. Hamachi*
Chemistry Letters , 49, 145-148 (2020) doi:10.1246/cl.190804 Open Access
265. The Power of Confocal Laser Scanning Microscopy in Supramolecular Chemistry: In situ Real‐time Imaging of Stimuli‐Responsive Multicomponent Supramolecular Hydrogels
R. Kubota, K. Nakamura, S. Torigoe, I. Hamachi*
ChemistryOPEN , 9,67-79 (2020) doi:10.1002/open.201900328 Open Access
264. Development of a cell-based ligand-screening system for identifying Hsp90 inhibitors
T. Ueda, T. Tamura*, I. Hamachi*
Biochemistry , 59, 2, 179-182 (2020) doi:10.1021/acs.biochem.9b00781
2010 - 2019
2010 - 2019
263. Electron Microscopic Detection of Single Membrane Proteins by a Specific Chemical Labeling
S. Tabata, M. Jevtic, N. Kurashige, H. Fuchida, M. Kido, K. Tani, N. Zenmyo, S. Uchinomiya, H. Harada, M. Itakura, I. Hamachi, R. Shigemoto*, A. Ojida*
iScience , 22, 256-268 (2019) doi:10.1016/j.isci.2019.11.025 Open Access
262. pH Nanosensor Using Electronic Spins in Diamond
T. Fujisaku, R. Tanabe, S. Onoda, R. Kubota, T. F. Segawa, F. T.-K. So, T. Ohshima, I. Hamachi, M. Shirakawa, R. Igarashi*
ACS Nano , 13, 10, 11726-11732 (2019) doi:10.1021/acsnano.9b05342
261. Construction of a Fluorescent Screening System of Allosteric Modulators for the GABAA Receptor Using a Turn-On Probe
S. Sakamoto, K. Yamaura, T. Numata, F. Harada, K. Amaike, R. Inoue, S. Kiyonaka, I. Hamachi*
ACS Central Science , 5, 9, 1541-1553 (2019) doi:10.1021/acscentsci.9b00539 Open Access
260. On-cell coordination chemistry: Chemogenetic activation of membrane-bound glutamate receptors in living cells
R. Kubota, S. Kiyonaka, I. Hamachi*
Methods in Enzymology , 622, 411-430 (2019) doi: 10.1016/bs.mie.2019.02.033
259. Optimized Reaction Pair of the CysHis Tag and Ni(II)-NTA Probe for Highly Selective Chemical Labeling of Membrane Proteins
N. Zenmyo, H. Tokumaru, S. Uchinomiya, H. Fuchida, S. Tabata, I. Hamachi, R. Shigemoto, A. Ojida*
Bulletin of the Chemical Society of Japan , 92, 995-1000 (2019) doi:10.1246/bcsj.20190034
258. Post-assembly fabrication of a functional multicomponent supramolecular hydrogel based on a self-sorting double network
W. Tanaka, H. Shigemitsu, T. Fujisaku, R. Kubota, S. Minami, K. Urayama, I. Hamachi*
Journal of the American Chemical Society , 141, 12, 4997–5004 (2019) doi: 10.1021/jacs.9b00715
257. Construction of ligand assay systems by protein-based semisynthetic biosensors
S. Sakamoto, S. Kiyonaka, I. Hamachi*
Current Opinion in Chemical Biology , 50, 10-18 (2019) doi:10.1016/j.cbpa.2019.02.011
256. Development of a nitric oxide-responsive labeling reagent for proteome analysis of live cells
Y. Nishikawa, T. Miki, M. Awa, K. Kuwata, T. Tamura, I. Hamachi*
ACS Chemical Biology , 14, 3, 397–404 (2019) doi: 10.1021/acschembio.8b01021
255. Selective and reversible modification of kinase cysteines with chlorofluoroacetamides
N. Shindo, H. Fuchida, M. Sato, K. Watari, T. Shibata, K. Kuwata, C. Miura, K. Okamoto, Y. Hatsuyama, K. Tokunaga, S. Sakamoto, S. Morimoto, Y. Abe, M. Shiroishi, J. M. M. Caaveiro, T. Ueda, T. Tamura, N. Matsunaga, T. Nakao, S. Koyanagi, S. Ohdo, Y. Yamaguchi, I. Hamachi, M. Ono, A. Ojida*
Nature Chemical Biology (2019) doi: 10.1038/s41589-018-0204-3
254. Recent Progress in Chemical Modification of Proteins
S. Sakamoto, I. Hamachi
Analytical Sciences, 35, 1, 5-27 (2019) doi:10.2116/analsci.18R003
253. Ligand-Directed N-Sulfonyl Pyridone Chemistry for Selective Native Protein Labeling and Imaging in Live Cell
M. Masuda, K. Matsuo, I. Hamachi*
Methods in Molecular Biology, 2008, 203-224 (2019) doi: 10.1007/978-1-4939-9537-0_16
252. Chemistry for Covalent Modification of Endogenous/Native Proteins: From Test Tubes to Complex Biological Systems
T. Tamura, I. Hamachi*
Journal of the American Chemical Society, 141, 7, 2782–2799 (2019) doi: 10.1021/jacs.8b11747 Open Access
251. Chemical Proteomics for Subcellular Proteome Analysis
H. Zhu, T. Tamura, I. Hamachi*
Current opinion in chemical biology,48, 1-7 (2019) doi:10.1016/j.cbpa.2018.08.001
250. Chemical profiling of the endoplasmic reticulum proteome using designer labeling reagents
A. Fujisawa, T. Tamura, Y. Yasueda, K. Kuwata, I. Hamachi*
Journal of the American Chemical Society, 140, 49, 17060-17070 (2018) doi: 10.1021/jacs.8b08606
249. Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons
H. T. T. Ha, S. Leal-Ortiz, K. Lalwani, S. Kiyonaka, I. Hamachi, S. P. Mysore, J. M. Montgomery, C. C. Garner*, J. R. Huguenard*, S. A. Kim*
Frontiers in molecular neuroscience, 11, 405 (2018) doi:10.3389/fnmol.2018.00405
248. Molecular Technologies in Life Innovation:Novel Molecular Technologies for Labeling and Functional Control of Proteins Under Live Cell Conditions
I. Hamachi, S. Kiyonaka, T. Tamura, R. Kubota
Molecular Technology vol.2, 297-328 (2018) doi:10.1002/9783527823987.vol2_c14
247. Chemogenetic Approach Using Ni (II) Complex–Agonist Conjugates Allows Selective Activation of Class A G-Protein-Coupled Receptors
R. Kubota, W. Nomura, T. Iwasaka, K. Ojima, S. Kiyonaka, I. Hamachi*
ACS Central Science, 4, 9, 1211–1221 (2018) doi: 10.1021/acscentsci.8b00390 Open Access
246. Imaging-based study on control factors over self-sorting of supramolecular nanofibers formed from peptide- and lipid-type hydrogelators
R. Kubota, S. Liu, H. Shigemitsu, K. Nakamura, W. Tanaka, M. Ikeda, I. Hamachi*
Bioconjugate Chemistry, 29, 6, 2058–2067 (2018) doi: 10.1021/acs.bioconjchem.8b00260 Open Access
245. Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-acyl-N-alkyl sulfonamide
T. Tamura, T. Ueda, T. Goto, T. Tsukidate, Y. Shapira, Y. Nishikawa, A. Fujisawa, I. Hamachi*
Nature Communications, 9, 1870 (2018) doi: 10.1038/s41467-018-04343-0 Open Access
244. Graftable SCoMPIs enable the labeling and X-Ray fluorescence imaging of proteins
S. Hostachy, M. Masuda, T. Miki, I. Hamachi, S. Sagan, O. Lequin, K. Medjoubi, A. Somogyi, N. Delsuc*, C. Policar*
Chemical Science, 9, 4483-4487 (2018) doi: 10.1039/C8SC00886H Open Access
243. In situ Construction of Protein-based Semisynthetic Biosensors
T. Ueda, T. Tamura, I. Hamachi*
ACS Sensors, 3, 527-539 (2018) doi: 10.1021/acssensors.7b00894
242. Endogenous membrane receptors labeling by reactive cytokines/growth factors to chase their dynamics in live cells
Y. Takaoka, S. Uchinomiya, D. Kobayashi, M. Endo, T. Hayashi, Y. Fukuyama, H. Hayasaka, M. Miyasaka, T. Ueda, I. Shimada, I. Hamachi*
Chem, 4, 1-14 (2018) doi: 10.1016/j.chempr.2018.03.021 Open Access
241. Ligand-directed chemistry of AMPA receptors confers live-cell fluorescent biosensors
S. Kiyonaka*, S. Sakamoto, S. Wakayama,Y. Morikawa, M. Tsujikawa, I. Hamachi*
ACS Chemical Biology, 13,7,1880–1889 (2018) doi: 10.1021/acschembio.7b01042
240. An adaptive supramolecular hydrogel comprising self-sorting double nanofibre networks
H. Shigemitsu, T. Fujisaku, W. Tanaka, R. Kubota, S. Minami, K. Urayama, I. Hamachi*
Nature Nanotechnology, 13, 165-172 (2018) doi: 10.1038/s41565-017-0026-6
239. Live-cell Protein Sulfonylation Based on Proximity-driven N-Sulfonyl Pyridone Chemistry
K. Matsuo, Y. Nishikawa, M. Masuda, I. Hamachi*
Angewandte Chemie International Edition, 15, 659-662 (2017) doi: 10.1002/anie.201707972
238. In Situ Protein Labeling in Complex Environments
T. Tamura, H. Shigemitsu, I. Hamachi
Comprehensive Supramolecular Chemistry II, 409–437. Oxford: Elsevier. (2017)
237. Ligand-Directed Tosyl and Acyl Imidazole Chemisrty
K. Matsuo, I. Hamachi
Chemoselective and Bioorthogonal Ligation Reactions: Concepts and Applications, (Chapter 6)147-163 (2017)
236. Recognition-driven chemical labeling of endogenous proteins in multi-molecular crowding live cells
K. Amaike, T. Tamura, I. Hamachi*
Chem. Commun. Feature Article, 53, 11972-11983 (2017) doi: 10.1039/c7cc07177a
235. Affinity-guided oxime chemistry for selective protein acylation in live tissue systems
T. Tamura, Z. Song, K. Amaike, S. Lee, S. Yin, S. Kiyonaka, I. Hamachi*
J. Am. Chem. Soc., 139, 14181-14191 (2017) doi: 10.1021/jacs.7b07339
234. A host-guest system based on collagen-like triple-helix hybridization
N. Delsuc*, S. Uchinomiya, A. Ojida, I. Hamachi
Chem. Commun., 53, 6856-6859 (2017) doi: 10.1039/c7cc03055j
233. Chemical labeling for visualizing native AMPA receptors in live neurons
S. Wakayama, S. Kiyonaka*, I. Arai, W. Kakegawa, S. Matsuda, K. Ibata, Y. L. Nemoto, A. Kusumi, M. Yuzaki, I. Hamachi*
Nat. Commun., 8, 14850 (2017) doi: 10.1038/ncomms14850 Open Access
232. Construction of Protein-Based Biosensors Using Ligand-Directed Chemistry for Detecting Analyte Binding
K. Yamaura*, S. Kiyonaka*, I. Hamachi*
Methods Enzymol., 589, 253-280 (2017) doi: 10.1016/bs.mie.2017.02.006
231. Design strategies of stimuli-responsive supramolecular hydrogels relied on structural analyses and cell-mimicking approaches
H. Shigemitsu, I. Hamachi*
Acc. Chem. Res., 50, 740-750 (2017) doi: 10.1021/acs.accounts.7b00070
230. Fluorescence sensing of inorganic phosphate and pyrophosphate using small molecular sensors and their applications
J. Wongkongkatep, A. Ojida, I. Hamachi*
Top. Curr. Chem., 375, 30 (2017) doi: 10.1007/s41061-017-0120-0
229. A conditional proteomics approach to identify proteins involved in zinc homeostasis
T. Miki, M. Awa, Y. Nishikawa, S. Kiyonaka, M. Wakabayashi, Y. Ishihama, I. Hamachi*
Nat. Methods, 13, 931-937 (2016) doi: 10.1038/nmeth.3998
228. A set of organelle-localizable reactive molecules for mitochondrial chemical proteomics in living cells and brain tissues
Y. Yasueda, T. Tamura, A. Fujisawa, K. Kuwata, S. Tsukiji, S. Kiyonaka, I. Hamachi*
J. Am. Chem. Soc., 138, 7592-7602 (2016) doi: 10.1021/jacs.6b02254
227. Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells
S. Kiyonaka*, R. Kubota, Y. Michibata, M. Sakakura, H. Takahashi, T. Numata, R. Inoue, M. Yuzaki, I. Hamachi*
Nat. Chem., 8, 958–967 (2016) doi: 10.1038/nchem.2554
226. Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry
K. Yamaura, S. Kiyonaka*, T. Numata, R. Inoue, I. Hamachi*
Nat. Chem. Biol., 12, 822-830 (2016) doi: 10.1038/nchembio.2150
225. Preparation of supramolecular hydrogel–enzyme hybrids exhibiting biomolecule-responsive gel degradation
H. Shigemitsu, T. Fujisaku, S. Onogi, T. Yoshii, M. Ikeda*, I. Hamachi*
Nat. Protoc., 11, 1744-1756 (2016) doi: 10.1038/nprot.2016.099
224. In situ real-time imaging of self-sorted supramolecular nanofibres
S. Onogi, H. Shigemitsu, T. Yoshii, T. Tanida, M. Ikeda, R. Kubota, I. Hamachi*
Nat. Chem., 8, 743-752 (2016) doi: 10.1038/nchem.2526
223. Nucleus-selective Chemical Proteomics Using Hoechst-tagged Reactive Molecules
Y. Yasueda, T. Tamura, I. Hamachi*
Chem. Lett., 45, 265-267 (2016) doi: 10.1246/cl.151083
222. Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function
J. Khoory, J. Estanislau, A. Elkhal, A. Lazaar, M. I. Melhorn, A. Brodsky, B. Illigens, I. Hamachi, Y. Kurishita, A. RIvanov, S. Shevkoplyas, N. I. Shapiro, I. C. Ghiran*
PloS one, 11, 1 (2016) doi: 10.1371/journal.pone.0141206
221. Validating Subcellular Thermal Changes Revealed by Fluorescent Thermosensors
S. Kiyonaka, R. Sakaguchi, I. Hamachi, T. Morii, T. Yoshizaki, Y. Mori*
Nature Methods, 12, 801-802 (2015) doi: 10.1038/nmeth.3548
220. Biomembrane-embedded Catalysts for Membrane-associated Protein Labeling on Red Blood Cells
Y. Yasueda, T. Tamura, K. Kuwata, Y. Takaoka, I. Hamachi*
Chem. Lett., 44, 1673-1675 (2015) doi: 10.1246/cl.150797
219. Supramolecular Assemblies Responsive to Biomolecules toward Biological Applications
H. Shigemitsu, I. Hamachi*
Chem. Asian J., 10, 2026-2038 (2015) doi: 10.1002/asia.201500563
218. Design of Coordination Interaction of Zn(II) Complex with Oligo-Aspartate Peptide to Afford a High-Affinity Tag-Probe Pair
H. Fuchida, S. Tabata, N. Shindo, I. Takashima, Q. Leng, Y. Hatsuyama, I. Hamachi, A. Ojida*
Bull. Chem. Soc. Jpn., 88, 784-791 (2015) doi: 10.1246/bcsj.20150037
217. Analysis of Cell-surface Receptor Dynamics Through Covalent Labeling by Catalyst-tethered Antibody
T. Hayashi, Y. Yasueda, T. Tamura, Y. Takaoka, I. Hamachi*
J. Am. Chem. Soc., 137, 5372-5380 (2015) doi: 10.1021/jacs.5b02867
216. Protein Recognition with Synthetic Small-molecular Binders toward Optical Protein Sensing in Vitro and in Live Cells
R. Kubota, I. Hamachi*
Chem. Soc. Rev., 44, 4454 - 4471 (2015) doi: 10.1039/c4cs00381k
215. Ligand-directed Dibromophenyl Benzoate Chemistry for Rapid and Selective Acylation of Intracellular Natural Proteins
Y. Takaoka, Y. Nishikawa, Y. Hashimoto, K. Sasaki, I. Hamachi*
Chem. Sci., 6, 3217 - 3224 (2015) doi: 10.1039/c5sc00190k Open Access
214. Chemically Reactive Supramolecular Hydrogel Coupled with a Signal Amplification System for Enhanced Analyte Sensitivity
T. Yoshii, S. Onogi, H. Shigemitsu, I. Hamachi*
J. Am. Chem. Soc., 137, 3360-3365 (2015) doi: 10.1021/ja5131534
213. Extended Affinity-guided DMAP Chemistry with Finely-tuned Acyl Donor for Intracellular FKBP12 Labeling
Z. Song, Y. Takaoka, Y. Kioi, K. Komatsu, T. Tamura, T. Miki, I. Hamachi*
Chem. Lett., 44, 333-335 (2015) doi: 10.1246/cl.141065 Open Access
212. Rapid and Quantitative Fluorescence Detection of Pathogenic Spore-forming Bacteria Using a Xanthene-Zn(II) Complex Chemosensor
P. Tiposoth, S. Khamsakhon, N. Ketsub, T. Pongtharangkul, I. Takashima, A. Ojida, I. Hamachi, J. Wongkongkatep*
Sensors and Actuators B, 209, 606-612 (2015) doi: 10.1016/j.snb.2014.11.113
211. Ligand-Directed Tosyl Chemistry for Selective Native Protein Labeling In Vitro, In Cells, and In Vivo
S. Tsukiji, I. Hamachi*
Methods in Mol. Biol., 1266, 243-263 (2015) doi: 10.1007/978-1-4939-2272-7_17
210. Development of AND Logic Gate-type Fluorescent Probe for Ratiometric Imaging of Autolysosome in Cell Autophagy
I. Takashima, R. Kawagoe, I. Hamachi, A. Ojida*
Chem. -A Euro. J., 21, 2038-2044 (2015) doi: 10.1002/chem.201405686
209. Labeling Proteins by Affinity-guided DMAP Chemistry
T. Tamura, I. Hamachi*
Methods in Mol. Biol., 1266, 229-242 (2015) doi: 10.1007/978-1-4939-2272-7_16
208. Intracellular Protein-responsive Supramolecules:Protein Sensing and In-cell Construction of Inhibitor Assay System
T. Yoshii, K. Mizusawa, Y. Takaoka, I. Hamachi*
J. Am. Chem. Soc., 136, 16635-16642 (2014) doi: 10.1021/ja508955y
207. Recent Progress in Design of Protein-based Fluorescent Biosensors and Their Cellular Applications
T. Tamura, I. Hamachi*
ACS Chemical Biology, 9, 2708-2717 (2014) doi: 10.1021/cb500661v
206. Live Cell Off-target Identification of Lapatinib Using Ligand-Directed Tosyl Chemistry
K. Yamaura, K. Kuwata, T. Tamura, Y. Kioi, Y. Takaoka, S. Kiyonaka, I. Hamachi*
Chem. Commun., 50, 14097-14100
(2014) doi: 10.1039/c4cc05885b
205. LDAI-based Chemical Labeling of Intact Membrane Proteins and its Pulse-Chase Analysis under Live Cell Conditions
T. Miki, S. Fujishima, K. Komatsu, K. Kuwata, S. Kiyonaka, I. Hamachi*
Chemistry & Biology, 21, 1013-1022 (2014) doi: 10.1016/j.chembiol.2014.07.013 Open Access
204. Two-photon Responsive Supramolecular Hydrogel for Controlling Materials Motion in Micrometer Space
T. Yoshii, M. Ikeda, I. Hamachi*
Angew. Chem. Int. Ed., 53, 7264–7267 (2014) doi: 10.1002/anie.201404158
203. Installing Logic-gate Responses to a Variety of Biological Substances in Supramolecular Hydrogel–enzyme Hybrids
M. Ikeda, T. Tanida, T. Yoshii, K. Kurotani, S. Onogi, K. Urayama, I. Hamachi*
Nat. Chem., 6, 511-518 (2014) doi: 10.1038/nchem.1937
202. Design of a Binuclear Ni(II)–iminodiacetic Acid (IDA) Complex for Selective Recognition and Covalent Labeling of His-tag Fused Proteins
I. Takahira, H. Fuchida, S. Tabata, N. Shindo, S. Uchinomiya, I. Hamachi, A. Ojida*
Bioorg. Med. Chem. Lett., 24, 2855–2858 (2014) doi: 10.1016/j.bmcl.2014.04.096
201. Hoechst Tagging: a Modular Strategy to Design Synthetic Fluorescent Probes for Live-cell Nucleus Imaging
A. Nakamura, K. Takigawa, Y. Kurishita, K. Kuwata, M. Ishida, Y. Shimoda, I. Hamachi*, S. Tsukiji*
Chem. Commun., 50, 6149-6152 (2014) doi: 10.1039/c4cc01753f
200. Ligand-directed Tosyl Chemistry for in Situ Native Protein Labeling and Engineering in Living Systems: from Basic Properties to Applications
S. Tsukiji, I. Hamachi*
Curr. Opin. Chem. Biol., 21, 136-143 (2014) doi: 10.1016/j.cbpa.2014.07.012
199. Design of Peptide-based Bolaamphiphile Exhibiting Heat-set Hydrogelation Via Retro-Diels-Alder Reaction
R. Ochi, T. Nishida, M. Ikeda, I. Hamachi*
J. Mater. Chem. B, 2, 1464-1469 (2014) doi: 10.1039/c3tb21680b
198. Design of Ratiometric Fluorescent Probes Based on Arene-Metal Ion Contact and Their Application to Cd(II) and Hydrogen Sulfide Imaging in Living Cell
I. Takashima, M. Kinoshita, R. Kawagoe, S. Nakagawa, M. Sugimoto, I. Hamachi, A. Ojida*
Chem. -A Euro. J., 20, 2184-2192 (2014) doi: 10.1002/chem.201304181
197. Peptide Tag/Probe Pairs Based on Coordination Chemistry for Protein Labeling
S. Uchinomiya, A. Ojida, I. Hamachi*
Inorg. Chem., 53, 1816-1823 (2014) doi: 10.1021/ic401612z
196. Heme Binding Mechanism of Structurally Similar Iron-Regulated Surface Determinant Near Transporter Domains of Staphylococcus aureus Exhibiting Different Affinities for Heme
Y. Moriwaki*, T. Terada, J. M. M. Caaveiro, Y. Takaoka, I. Hamachi, K. Tsumoto, K. Shimizu
Biochemistry, 52, 8866-8877 (2013) doi: 10.1021/bi4008325
195. Selective Binding of Antimicrobial Porphyrins to the Heme-receptor IsdH-NEAT3 of Staphylococcus Aureus
N. T. Vu, Y. Moriwaki, J. M. M. Caaveiro*, T. Terada, H. Tsutsumi, I. Hamachi, K. Shimizu, K. Tsumoto*
Protein Sci., 22, 942-953 (2013) doi: 10.1002/pro.2276
194. CR1-mediated ATP Release by Human Red Blood Cells Promotes CR1 Clustering and Modulates the Immune Transfer Process
M. I. Melhorn, A. S. Brodsky, J. Estanislau, J. A. Khoory, B. Illigens, I. Hamachi, Y. Kurishita, A. D. Fraser, A. Nicholson-Weller, E. Dolmatova, H. S. Duffy, I. C. Ghiran*
J. Biol. Chem., 288, 31139-31153 (2013) doi: 10.1074/jbc.M113.486035 Open Access
193. Genetically Encoded Fluorescent Thermosensors Visualize Subcellular Thermoregulation in Living Cells
S. Kiyonaka, T. Kajimoto, R. Sakaguchi, D. Shinmi, M. Omatsu-Kanbe, H. Matsuura, H. Imamura, T. Yoshizaki, I. Hamachi, T. Morii, Y. Mori*
Nat. Methods, 10, 1232-1238 (2013) doi: 10.1038/nmeth.2690
192. Selective Labeling and Imaging of Protein Using Metal Complex
Y. Kurishita, I. Hamachi
Coordination Chemistry in Protein Cages, 223-239 (2013) doi: 10.1002/9781118571811.ch9
191. Disassembly-driven Turn-on Sensing of Enzyme Activity by using Substrate-based Fluorescent Nanoprobe
Y. Takaoka, Y. Fukuyama, K. Matsuo, I. Hamachi*
Chem. Lett., 42, 1426-1428 (2013) doi: 10.1246/cl.130697 Open Access
190. Synthetic Self-Localizing Ligands That Control The Spatial Location of Proteins in Living Cells
M. Ishida, H. Watanabe, K. Takigawa, Y. Kurishita, C. Oki, A. Nakamura, I. Hamachi*, S. Tsukiji*
J. Am. Chem. Soc., 135, 12684-12689 (2013) doi: 10.1021/ja4046907
189. Semisynthetic Lectin-Dimethylaminopyridine Conjugates for Labeling and Profiling Glycoproteins on Live Cell Surfaces
T. Hayashi, Y. Sun, T. Tamura, K. Kuwata, Z. Song, Y. Takaoka, I. Hamachi*
J. Am. Chem. Soc., 135, 12252-12258 (2013) doi: 10.1021/ja4043214
188. Specific Detection and Imaging of Enzyme Activity by Signal Amplifiable Self- Assembling 19F-MRI Probes
K. Matsuo, R. Kamada, K. Mizusawa, H. Imai, Y. Takayama, M. Narazaki, T. Matsuda, Y. Takaoka, I. Hamachi*
Chem. -A Euro. J., 19, 12875-12883 (2013) doi: 10.1002/chem.201300817
187. Fluorophore Labeling of Native FKBP12 by Ligand-directed Tosyl Chemistry Allows Detection of Its Molecular Interactions in Vitro and in Living Cells
T. Tamura, Y. Kioi, T. Miki, S. Tsukiji, I. Hamachi*
J. Am. Chem. Soc., 135, 6782-6785 (2013) doi: 10.1021/ja401956b
186. In-Cell Covalent Labeling of Reactive His-Tag Fused Proteins
S. Uchinomiya, H. Nonaka, S. Wakayama, A. Ojida, I. Hamachi*
Chem. Commun., 49, 5022-5024 (2013) doi: 10.1039/c3cc41979g
185. One-step Construction of Caged Carbonic Anhydrase I Using a Ligand-directed Acyl Imidazole-based Protein Labeling Method
K. Matsuo, Y. Kioi, R. Yasui, Y. Takaoka, T. Miki, S. Fujishima, I. Hamachi*
Chem. Sci., 4, 2573 - 2580 (2013) doi: 10.1039/c3sc50560j
184. Quantitative Comparison of Protein Dynamics in Live Cells and in Vitro by In-cell 19F-NMR
Y. Takaoka , Y. Kioi , A. Morito , J. Otani , K. Arita , E. Ashihara , M. Ariyoshi , H. Tochio , M. Shirakawa, I. Hamachi*
Chem. Commun., 49, 2801-2803 (2013) doi: 10.1039/c3cc39205h
183. Protein Organic Chemistry and Application for Labeling and Engineering in Live-Cell Systems
Y. Takaoka, A. Ojida, I. Hamachi*
Angew. Chem. Int. Ed., 52, 4088-4106 (2013) doi: 10.1002/anie.201207089
182. Supramolecular Hydrogels Based on Bola-amphiphilic Glycolipids Showing Color Change in Response to Glycosidases
R. Ochi, K. Kurotani, M. Ikeda, S. Kiyonaka, I. Hamachi*
Chem. Commun., 49, 2115-2117 (2013) doi: 10.1039/c2cc37908b
181. Label-Free Fluorescent Detection of Loop-Mediated Isothermal Amplification of Nucleic Acid Using Pyrophosphate-selective Xanthene-based Zn(II)-Coordination Chemosensor
E. Kittiloespaisan, A. Ojida, I. Hamachi, Y. Seetang-Nun, W. Kiatpathomchai, J. Wongkongkatep*
Chem. Lett., 41, 1666-1668 (2012) doi: 10.1246/cl.2012.1666
180. Organelle-Localizable Fluorescent Chemosensors for Site-Specific Multicolor Imaging of Nucleoside Polyphosphate Dynamics in Living Cells
Y. Kurishita, T. Kohira, A. Ojida, I. Hamachi*
J. Am. Chem. Soc., 134, 18779–18789 (2012) doi: 10.1021/ja308754g
179. Specific Cell Surface Protein Imaging by Extended Self-assembling Fluorescent Turn-on Nanoprobes
K. Mizusawa, Y. Takaoka, I. Hamachi*
J. Am. Chem. Soc., 134, 13386-13395 (2012) doi: 10.1021/ja304239g
178. Heat-Induced Morphological Transformation of Supramolecular Nanostructures by Retro-Diels-Alder Reaction
M. Ikeda, R. Ochi, Y. Kurita, D. J. Pochan, I. Hamachi*
Chem. -A Euro. J., 18, 13091-13096 (2012) doi: 10.1002/chem.201201670
177. What do we want to see and how?
Itaru Hamachi*
Curr. Opin. Chem. Biol., 16, 593-594 (2012) doi: 10.1016/j.cbpa.2012.10.032
176. Traceless Affinity Labeling of Endogenous Proteins for Functional Analysis in Living Cells
T. Hayashi, I. Hamachi* doi: 10.1021/ar200334r
Accounts of Chemical Research, 45, 1460-1469 (2012)
175. Bacteria Interface Pickering Emulsions Stabilized by Self-assembled Bacteria–Chitosan Network
P. Wongkongkatep, K. Manopwisedjaroen, P. Tiposoth, S. Archakunakorn, T. Pongtharangkul, M. Suphantharika, K. Honda, I. Hamachi, J. Wongkongkatep*
Langmuir, 28, 5729-5736 (2012) doi: 10.1021/la300660x
174. Ligand-directed Acyl Imidazole Chemistry for Labeling of Membrane-bound Proteins on Live Cells
S. Fujishima, R. Yasui, T. Miki, A. Ojida, I. Hamachi*
J. Am. Chem. Soc., 134, 3961-3964 (2012) doi: 10.1021/ja2108855
173. A Supramolecular Hydrogel Containing Boronic Acid-appended Receptor for Fluorocolorimetric Sensing of Polyols with Paper Platform
M. Ikeda, K. Fukuda, T. Tanida, T. Yoshii, I. Hamachi*
Chem. Commun., 48, 2716-2718 (2012) doi: 10.1039/c2cc17503g
172. Native FKBP12 Engineering by Ligand-Directed Tosyl Chemistry: Labeling Properties and Application to Photo-Cross-Linking of Protein Complexes in Vitro and in Living Cells
T. Tamura, S. Tsukiji, I. Hamachi*
J. Am. Chem. Soc., 134, 2216-2226 (2012) doi: 10.1021/ja209641t
171. Phosphopeptide-Dependent Labeling of 14-3-3ζ Proteins by Fusicoccin-Based Fluorescent Probes
M. Takahashi, A. Kawamura, N. Kato, T. Nishi, I. Hamachi, J. Ohkanda*
Angew. Chem. Int. Ed., 51, 509-512 (2012) doi: 10.1002/anie.201106995
170. Design of Multinuclear Zn(II) Complex as New Molecular Probe for Fluorescence Imaging of His-tag Fused Proteins
S. Fujishima, H. Nonaka, S. Uchinomiya, Y. A. Kawase, A. Ojida, I. Hamachi*
Chem. Commun., 48, 594-596 (2012) doi: 10.1039/c1cc16263b
169. Meter-Long and Robust Supramolecular Strands Encapsulated in Hydrogel Jackets
D. Kiriya, M. Ikeda, H. Onoe, M. Takinoue, H. Komatsu, Y. Shimoyama, I. Hamachi, S. Takeuchi*
Angew. Chem. Int. Ed., 51, 1553-1557 (2012) doi: 10.1002/anie.201104043
168. Molecular Basis of Recognition of Antibacterial Porphyrins by Heme- Transporter IsdH-NEAT3 of Staphylococcus aureus
Y. Moriwaki, J. M. M. Caaveiro, Y. Tanaka, H. Tsutsumi, I. Hamachi, K. Tsumoto*
Biochemistry, 50, 7311-7320 (2011) doi: 10.1021/bi200493h
167. Chemical Cell-Surface Receptor Engineering Using Affinity-Guided, Multivalent Organocatalysts
H. Wang, Y. Koshi, D. Minato, H. Nonaka, S. Kiyonaka, Y. Mori, S. Tsukiji, I. Hamachi*
J. Am. Chem. Soc., 133, 12220-12228 (2011) doi: 10.1021/ja204422r
166. Systematic Study of Protein Detection Mechanism of Self-assembling 19F NMR/MRI Nanoprobes toward Rational Design and Improved Sensitivity
Y. Takaoka, K. Kiminami, K. Mizusawa, K. Matsuo, M. Narazaki, T. Matsuda, I. Hamachi*
J. Am. Chem. Soc., 133, 11725-11731 (2011) doi: 10.1021/ja203996c
165. Construction of a (19)F-lectin biosensor for glycoprotein imaging by using affinity-guided DMAP chemistry
Y. Sun, Y. Takaoka, S. Tsukiji, M. Narazaki, T. Matsuda, I. Hamachi*
Bioorg. Med. Chem. Lett., 21, 4393-4396 (2011) doi: 10.1016/j.bmcl.2011.06.038
164. Rigid Luminescent Bis-Zinc(II)–Bis-Cyclen Complexes for the Detection of Phosphate Anions and Non-Covalent Protein Labeling in Aqueous Solution
M. Bhuyan, E. Katayev, S. Stadlbauer, H. Nonaka, A. Ojida, I. Hamachi, B. König*
Eur. J. Org. Chem., 15, 2807–2817 (2011) doi: 10.1002/ejoc.201100103
163. Stiff, Multistimuli-Responsive Supramolecular Hydrogel as Unique Molds for 2D/3D Microarchitectures of Live Cells
H. Komatsu, S. Tsukiji, M. Ikeda, I. Hamachi*
Chem. Asian J., 6, 2368-2375 (2011) doi: 10.1002/asia.201100134
162. Rational Molecular Design of Stimulus-responsive Supramolecular Hydrogel Based on Dipeptides
M. Ikeda, T. Tanida, T. Yoshii, I. Hamachi*
Adv. Mater., 23, 2819-2822 (2011) doi: 10.1002/adma.201004658
161. Mechanical Reinforcement of Supramolecular Hydrogel Through Incorporation of Multiple Noncovalent Interactions
H. Komatsu, M. Ikeda, I. Hamachi*
Chem. Lett., 40, 198-200 (2011) doi: 10.1246/cl.2011.198
160. Montmorillonite-Supramolecular Hydrogel Hybrid for Fluorocolorimetric Sensing of Polyamines
M. Ikeda, T. Yoshii, T. Matsui, T. Tanida, H. Komatsu, I. Hamachi*
J. Am. Chem. Soc., 133, 1670-1673 (2011) doi: 10.1021/ja109692z
159. Mechanisms of Chemical Protein 19F-Labeling and NMR-Based Biosensor Construction In Vitro and In Cells Using Self-Assembling Ligand-Directed Tosylate Compounds
Y. Takaoka, Y. Sun, S. Tsukiji, I. Hamachi*
Chem. Sci., 2, 511-520 (2011) doi: 10.1039/c0sc00513d
158. Supramolecular hydrogel-based protein and chemosensor array
M. Ikeda, R. Ochi, I. Hamachi*
Lab on a Chip, 10, 3325-3334 (2010) doi: 10.1039/c004908e
157. Rational Design of FRET-Based Ratiometric Chemosensors for in Vitro and in Cell Fluorescence Analyses of Nucleoside Polyphosphates
Y. Kurishita, T. Kohira, A. Ojida, I. Hamachi*
J. Am. Chem. Soc., 132, 13290-13299 (2010) doi: 10.1021/ja103615z
156. Supramolecular Hydrogel Capsule Showing Prostate Specific Antigen-responsive Function for Sensing and Targeting Prostate Cancer Cell
M. Ikeda, R. Ochi, A. Wada, I. Hamachi*
Chem. Sci., 1, 491-498 (2010) doi: 10.1039/c0sc00278j
155. Selective Covalent Labeling of Tag-Fused GPCR Proteins on Live Cell Surface with a Synthetic Probe for Their Functional Analysis
H. Nonaka, S. Fujishima, S. Uchinomiya, A. Ojida, I. Hamachi*
J. Am. Chem. Soc., 132, 9301-9309 (2010) doi: 10.1021/ja910703v
154. Disassembly-Driven Turn-On Fluorescent Nanoprobes for Selective Protein Detection
K. Mizusawa, Y. Ishida, Y. Takaoka, M. Miyagawa, S. Tsukiji, I. Hamachi*
J. Am. Chem. Soc., 132, 7291-7293 (2010) doi: 10.1021/ja101879g
153. Fluidic Supramolecular Nano- and Microfibres as Molecular Rails for Regulated Movement of Nanosubstances
S. Tamaru, M. Ikeda, Y. Shimidzu, S. Matsumoto, S. Takeuchi, I. Hamachi*
Nat. Commun., 1, 20 (2010) doi: 10.1038/ncomms1018
152. Thermoresponsive Fluorescent Sensor Based on Core/Shell Nanocomposite Composed of Gold Nanoparticles and Poly(N-isopropylacrylamide)
J. Wongkongkatep*, R. Ladadat, W. Lappermpunsap, P. Wongkongkatep, P. Phinyocheep, A. Ojida, I. Hamachi
Chem. Lett., 39, 184-185 (2010) doi: 10.1246/cl.2010.184
151. Development of Highly Sensitive Fluorescent Probes for Detection of Intracellular Copper(I) in Living Systems
M. Taki*, S. Iyoshi, A. Ojida, I. Hamachi, Y. Yamamoto
J. Am. Chem. Soc., 132, 5938-5939 (2010) doi: 10.1021/ja100714p
150. Binuclear NiII-DpaTyr Complex as a High Affinity Probe for an Aspartate Tag Tethered to Proteins
A. Ojida, S. Fujishima, K. Honda, H. Nonaka, S. Uchinomiya, I. Hamachi*
Chem. Asian J., 5, 877-886 (2010) doi: 10.1002/asia.200900362
2000 - 2009
2000 - 2009
149. Recent Progress in Strategies for Creation of Protein-based Fluorescent Biosensors
H. Wang, E. Nakata, I. Hamachi*
ChemBioChem, 10, 2560-2577 (2009) doi: 10.1002/cbic.200900249
148. FLAG-tag Selective Covalent Protein Labeling Via a Binding-induced Acyl-transfer Reaction
H. Nonaka, S. Fujishima, S. Uchinomiya, A. Ojida, I. Hamachi*
Bioorg. Med. Chem. Lett., 19, 6696-6699 (2009) doi: 10.1016/j.bmcl.2009.09.122
147. Molecular Characterization of Flubendiamide Sensitivity in the Lepidopterous Ryanodine Receptor Ca2+ Release Channel
K. Kato, S. Kiyonaka, Y. Sawaguchi, M. Tohnishi, T. Masaki, N. Yasokawa, Y. Mizuno, E. Mori, K. Inoue, I. Hamachi, H. Takeshima, Y. Mori*
Biochemistry, 48, 10342–10352 (2009) doi: 10.1021/bi900866s
146. Thin-film Assembly of Diethanolamine-based Lipidic Material as Potential Gene Carrier in Mouse Embryonic Neural Stem Cells
K. Kusumoto*, S. Yamashita, T. Nagata, T. Ido, I. Hamachi, T. Akao
J. Biomed. Mater. Res. A, 91A, 1-10 (2009) doi: 10.1002/jbm.a.32159
145. Self-assembling Nano-probes Displaying Off/On 19F NMR Signals for Protein Detection and Imaging
Y. Takaoka, T. Sakamoto, S. Tsukiji, M. Narazaki, T. Matsuda, H. Tochio, M. Shirakawa, I. Hamachi*
Nat. Chem., 1, 557-561 (2009) doi: 10.1038/nchem.365
144. Site-Specific Covalent Labeling of His-tag Fused Proteins with a Reactive Ni(II)-NTA Probe
S. Uchinomiya, H. Nonaka, S. Fujishima, S. Tsukiji, A. Ojida, I. Hamachi*
Chem. Commun., 39, 5880-5882 (2009) doi: 10.1039/b912025d
143. Real-Time Fluorescence Monitoring of GSK3-Catalyzed Phosphoryation by Use of a BODIPY-Based Zn(II)-Dpa Chemosensor
T. Sakamoto, M. Inoue, A. Ojida, I. Hamachi*
Bioorg. Med. Chem. Lett., 19, 4175-4177 (2009) doi: 10.1016/j.bmcl.2009.05.121
142. Quenched Ligand-Directed Tosylate Reagents for One-Step Construction of Turn-On Fluorescent Biosensors
S. Tsukiji, H. Wang, M. Miyagawa, T. Tamura, Y. Takaoka, I. Hamachi*
J. Am. Chem. Soc., 131, 9046-9054 (2009) doi: 10.1021/ja902486c
141. Sequence Selective Dual-Emission Detection of (i, i+1) Bis-Phosphorylated Peptide Using Diazastilbene-Type Zn(II)-Dpa Chemosensor
Y. Ishida, M. Inoue, T. Inoue, A. Ojida, I. Hamachi*
Chem. Commun., 20, 2848-2850 (2009) doi: 10.1039/b905814a
140. Fluorescent BODIPY-Based Zn(II)-Complex as a Molecular Probe for Selective Detection of Neurofibrillary Tangles in the Brains of Alzheimer’s Disease Patients
A. Ojida, T. Sakamoto, M. Inoue, S. Fujishima, G. Lippens, I.Hamachi*
J. Am. Chem. Soc., 131, 6543-6548 (2009) doi: 10.1021/ja9008369
139. Supramolecular Hydrogel Exhibiting Four Basic Logic Gate Functions to Fine-tune Substance Release
H. Komatsu, S. Matsumoto, S. Tamaru, K. Kaneko, M. Ikeda, I. Hamachi*
J. Am. Chem. Soc., 131, 5580-5585 (2009) doi: 10.1021/ja8098239
138. Selective and Direct Inhibition of TRPC3 Channels Underlies Biological Activities of a Pyrazole Compound
S. Kiyonaka, K. Kato, M. Nishida, K. Mio, T. Numaga, Y. Sawaguchi, T. Yoshida, M. Wakamori,E. Mori, T. Numata, M. Ishii, H. Takemoto, A. Ojida, K. Watanabe, A. Uemura, H. Kurose,T. Morii, T. Kobayashi, Y. Sata, C. Sato, I. Hamachi, Y. Mori*
Proc. Natl. Acad. Sci. USA, 106, 5400-5405 (2009) doi: 10.1073/pnas.0808793106
137. Ligand-directed Tosyl Chemistry for Protein Labeling in Vivo
S. Tsukiji, M. Miyagawa, Y. Takaoka, T. Tamura, I. Hamachi*
Nat. Chem. Biol., 5, 341-343 (2009) doi: 10.1038/nchembio.157
136. MCM-Enzyme-Supramolecular Hydrogel Hybrid as a Fluorescence Sensing Material for Poly-anions of Biological Significance
A. Wada, S. Tamaru, M. Ikeda, I. Hamachi*
J. Am. Chem. Soc., 131, 5321-5330 (2009) doi: 10.1021/ja900500j
135. Molecular Recognition, Fluorescence Sensing, and Biological Assay of Phosphate Anion Derivatives Using Artificial Zn(II)-Dpa Complexes
T. Sakamoto, A. Ojida, I. Hamachi*
Chem. Commun., 8, 141-152 (2009) doi: 10.1039/b812374h
134. Recent progress of phosphate derivatives recognition utilizing artificial small molecular receptors in aqueous media
S. Tamaru*, I. Hamachi
Structure and Bonding,「Recognition of Anions」, 129, 95-125 (2008) doi: 10.1007/430_2007_072
133. Real-time Off/On-mode Fluorescence Assay for Enzyme Reactions Involving Nucleoside Polyphosphates by Use of a Xanthene Zn(II)-Dpa Chemosensor
T. Kohira, I. Takashima, H. Nonaka, A. Ojida, I. Hamachi*
Chem. Lett., 37, 1164-1165 (2008) doi: 10.1246/cl.2008.1164
132. Fluorescence Imaging of Intracellular Cadmium Using a Dual-excitation Ratiometric Chemosensor
M. Taki*, M. Desaki, A. Ojida, T. Hirayama, I. Hamachi, Y. Yamamoto, S. Iyoshi
J. Am. Chem. Soc., 130, 12564-12565 (2008) doi: 10.1246/cl.2008.1164
131. Three-dimensional Encapsulation of Live Cells by Using a Hybrid Matrix of Nanoparticles in a Supramolecular Hydrogel
M. Ikeda, S. Ueno, S. Matsumoto, Y. Shimizu, H. Komatsu, K. Kusumoto, I. Hamachi*
Chem. -A Euro. J., 14, 10808-10815 (2008) doi: 10.1002/chem.200801144
130. Turn-on Fluorescence Sensing of Nucleside Polyphosphates Using a Xanthene-Based Zn(II) Complex Chemosensor
A. Ojida, I. Takashima, T. Kohira, H. Nonaka, I. Hamachi*
J. Am. Chem. Soc., 130, 12095-12101 (2008) doi: 10.1021/ja803262w
129. Mechanical Reinforcement of Supramolecular Hydrogel Comprising Artificial Glyco-lipid Through Supramolecular Copolymerization
M. Ikeda, Y. Shimizu, S. Matsumoto, H. Komatsu, S. Tamaru, T. Takigawa, I. Hamachi*
Macromol. Biosc., 8, 1019-1025 (2008) doi: 10.1002/mabi.200800061
128. Affinity Labeling-Based Introduction of a Reactive Handle for Natural Protein Modification
H. Wakabayashi, M. Miyagawa, Y. Koshi, Y. Takaoka, S. Tsukiji, I. Hamachi*
Chem. -An Asian J., 3, 1134-1139 (2008) doi: 10.1002/asia.200800057
127. Photo Gel-sol/Sol-gel Transition and its Patterning of a Supramolecular Hydrogel as Stimuli-respnsive Biomaterials
S. Matsumoto, S. Yamaguchi, S. Ueno, H. Komatsu, M. Ikeda, K. Ishizuka, Y. Iko, K. V. Tabata, H. Aoki, S. Ito, H. Noji, I. Hamachi*
Chem. -A Euro. J., 14, 3977-3986 (2008) doi: 10.1002/chem.200701904
126. Photo-responsive Gel Droplet as a Nano- or Pico-liter Container Comprising a Supramolecular hydrogel
S. Matsumoto, S. Yamaguchi, A. Wada, T. Matsui, M. Ikeda, I. Hamachi*
Chem. Commun., 13, 1545-1547 (2008) doi: 10.1039/b719004b
125. Artificial Receptors Designed for Intracellular Delivery of Anionic Phosphate Derivatices
T. Kohira, K. Honda, A. Ojida, I. Hamachi*
ChemBioChem, 9, 698-701 (2008) doi: 10.1002/cbic.200700627
124. Thermally Responsive Supramolecular Nano-meshes for on/off Switching of the Rotary Motion of F1-ATPase at a Single Molecular Level
S. Yamaguchi, S. Matsumoto, K. Ishizuka, Y. Iko, K. V. Tabata, H. Arata, H. Fujita, H. Noji, I. Hamachi*
Chem. -A Euro. J., 14, 1891-1896 (2008) doi: 10.1002/chem.200701285
123. Ratiometric Fluorescent Biosensor for Real-time and Label-free Monitoring of Fine Saccharide Metabolic Pathways
E. Nakata, H. Wang, I. Hamachi*
ChemBioChem, 9, 25-28 (2008) doi: 10.1002/cbic.200700364
122. Target-Specific Chemical Acylation of Lectins by Ligand-Tethered DMAP Catalysts
Y. Koshi, E. Nakata, M. Miyagawa, S. Tsukiji, T. Ogawa, I. Hamachi*
J. Am. Chem. Soc., 130, 245-251 (2008) doi: 10.1021/ja075684q
121. Development of New Methods to Intruduce Unnatural Function into Native Proteins for Protein Engineering
E. Nakata, S. Tsukiji, I. Hamachi*
Bull. Chem. Soc. Jpn., 80, 1268-1279 (2007) doi: 10.1246/bcsj.80.1268 Open Access
120. Lectin Functionalizaion by Post-Photo Affinity Labeling Modification(P-PLAM)
Y. Koshi, E. Nakata, I. Hamachi*
Trends in Glycoscience and Glycotechnology, 19, 121–131 (2007) doi: 10.4052/tigg.19.121 Open Access
119. Non-enzymatic Covalent Protein Labeling Using a Reactive Tag
H. Nonaka, S. Tsukiji, A. Ojida, I. Hamachi*
J. Am. Chem. Soc., 129, 15777-15779 (2007) doi: 10.1021/ja074176d
118. Pyrene Excimer Based Dual-Emission detection of a Oligoaspartate Tag Fused Protein Using Zn(II)-DpaTyr Probe
K. Honda, S. Fujishima, A. Ojida, I. Hamachi*
ChemBioChem, 8, 1370-1372 (2007) doi: 10.1002/cbic.200700146
117. Design of a Hybrid Biosensor for Enhanced Phosphopeptide Recognition Based on a Phosphoprotein Binding Domain Coupled with a Fluorescent Chemosensor
T. Anai, E. Nakata, Y. Koshi, A. Ojida, I. Hamachi*
J. Am. Chem. Soc., 129, 6232-6239 (2007) doi: 10.1021/ja0693284
116. Design and Synthesis of Bis(Zn(II)-dipicolylamine)-based Fluorescent Artificial Chemosensors for Phosphorylated Proteins/peptides
A. Ojida, I. Hamachi*
Bull. Chem. Soc. Jpn., 1,35-46 (2006) doi: 10.1246/bcsj.79.35 Open Access
115. Design of Dual-Emission Chemosensors for Ratiometric Detection of ATP Derivatives
A. Ojida, Y. Miyahara, J. Wongkongkatep, S. Tamaru, K. Sada, I. Hamachi*
Chem. Asian J., 1, 555-563 (2006) doi: 10.1002/asia.200600137
114. Ratiometric Fluorescence Detection of a Tag Fused Protein using the Dual-emission Artificial Molecular Probe
K. Honda, E. Nakata, A. Ojida, I. Hamachi*
Chem. Commun., 38, 4024-4026 (2006) doi: 10.1039/b608684e
113. A Fluorescent Lectin Array Using Supramolecular Hydrogel for Simple Detection and Pattern Profiling for Various Glyco-conjugates
Y. Koshi, E. Nakata, H. Yamane, I. Hamachi*
J. Am. Chem. Soc., 128, 10413-10422 (2006) doi: 10.1021/ja0613963
112. Bis(Dpa-Zn(II)) Appended Xanthone: Excitation Ratiometric Chemosensor for Phosphate Anion Derivatives Based on Anion-Induced Rearrangement of Coordination Chemistry
A. Ojida, H. Nonaka, Y. Miyahara, S. Tamaru, K. Sada, I. Hamachi*
Angew. Chem. Int. Ed., 45, 5518-5521 (2006) doi: 10.1002/anie.200601315
111. Oligo-Asp Tag/Zn(II)-Complex Probe as a New Pair for Labeling and Fluorescence Imaging of Proteins
A. Ojida, K. Honda, D. Shinmi, S. Kiyonaka, Y. Mori, I. Hamachi*
J. Am. Chem. Soc., 128, 10452-10459 (2006) doi: 10.1021/ja0618604
110. Identification of a New Class of Low Molecular Weight Antagonists against the Chemokine Receptor CXCR4 Having the Dipicolylamine-Zinc(II) Complex Structure
H. Tamamura*, A. Ojida, T. Ogawa, H. Tsutsumi, H. Masuno, H. Nakashima, N. Yamamoto, I. Hamachi, N. Fujii*
J. Med. Chem., 49, 3412-3415 (2006) doi: 10.1021/jm060025u
109. One-pot and Sequential Organic Chemistry on an Enzyme Surface to Tether a Fluorescent Probe at the Proximity of the Active Site with Restoring Enzyme Activity
Y. Takaoka, H. Tsutsumi, N. Kasagi, E. Nakata, I. Hamachi*
J. Am. Chem. Soc., 128, 3273-3280 (2006) doi: 10.1021/ja057926x
108. Effective Disruption of Phosphoprotein-Protein Surface Interaction Using Zn(II) Dipicolylamine-Based Artificial Receptors via Two-Point Interaction
A. Ojida, M. Inoue, Y. Mito-oka, H. Tsutsumi, K. Ssda, I. Hamachi*
J. Am. Chem. Soc., 128, 2052-2058 (2006) doi: 10.1021/ja056585k
107. Label-Free, Real-Time Glycosyltransferase Assay Based on a Fluorescent Artificial Chemosensor
J. Wongkongkatep, Y. Miyahara, A. Ojida, I. Hamachi*
Angew. Chem. Int. Ed., 45, 665-668 (2006) doi: 10.1002/anie.200503107
106. Double-Modification of Lectin Using Two Distinct Chemistries for Fluorescent Ratiometric Sensing and Imaging Saccharides in Test Tube or in Cell
E. Nakata, Y. Koshi, E. Koga, Y. Katayama, I. Hamachi*
J. Am. Chem. Soc., 127, 13253-13261 (2005) doi: 10.1021/ja052731a
105. Globular Self-aggregates Formed with A Urea-functionalized Resorcinarene Derivative in Chloroform
O. Hayashida*, S. Matsumoto, I. Hamachi*
Chem. Lett., 34, 1276-1277 (2005) doi: 10.1246/cl.2005.1276
104. Three Distinct Reading-out Modes for Enzyme Acticity can be Operated in Semi-wet Supramolecular Hydrogel
S. Tamaru, S. Kiyonaka, I. Hamachi*
Chem. -A Euro. J., 11, 7294-7304 (2005) doi: 10.1002/chem.200500666
103. Cooperation between Artificial Receptor and Supramolecular Hydrogel for Sensing and Discriminating Phosphate Derivatives
S. Yamaguchi, I. Yoshimura, T. Kohira, S. Tamaru, I. Hamachi*
J. Am. Chem. Soc., 127, 11835-11841 (2005) doi: 10.1021/ja052838y
102. Luminescent Saccharide Biosensor by Using Lanthanide-Bound Lectin Labeled with Fluorescein
Y. Koshi, E. Nakata, I. Hamachi*
ChemBioChem, 6, 1349-1352 (2005) doi: 10.1002/cbic.200500072
101. Simple and Practical Semi-wet Protein/Peptide Array Utilizing a Micelle-mixed Agarose Hydrogel
S. Tamaru, S. Yamaguchi, I. Hamachi*
Chem. Lett., 34, 294-295 (2005) doi: 10.1246/cl.2005.294
100. Suzuki Coupling for Protein Modification
A. Ojida, H. Tsutsumi, N. Kasagi, I. Hamachi*
Tetrahedoron Lett., 46, 3301-3305 (2005) doi: 10.1016/j.tetlet.2005.03.094
99. Synthesis and Guest-binding Study of Polytopic Multi(cyclophane) Hosts
O. Hayashida*, Y. Takaoka, I. Hamachi*
Tetrahedoron Lett., 46, 6589-6592 (2005) doi: 10.1016/j.tetlet.2005.07.010
98. Cyclophane-lectin Conjugates as A New Class of Water-soluble Host
O. Hayashida*, I. Hamachi
J. Incl. Phenom. Macro. Chem., 53, 57-61 (2005) doi: 10.1007/s10847-005-0993-3
97. Preparation and Unique Circular Dichroism Phenomena of Urea-Functionalized Self-Folding Resorcinarenes Bearing Chiral Termini through Asymmetric Hydrogen Bonding Belts
O. Hayashida*, J. Ito, S. Matsumoto, I. Hamachi
Org. Biomol. Chem., 3, 654-660 (2005) doi: 10.1039/b418880b
96. pH-Responsive Shrinkage/Swelling of Supramolecular Hydrogel Comprised of Two Components of Amphiphilic Small Molecules
S-L. Zhou, S. Matsumoto, H-D Tian, H. Yamane, A. Ojida, S. Kiyonaka, I. Hamachi*
Chem. -A Euro. J., 11, 1130-1136 (2005) doi: 10.1002/chem.200400677
95. Recognition and Fluorescence Sensing of Specific Amino Acid Residue on Protein Surface Using Designed Molecules
A. Ojida, Y. Miyahara, T. Kohira, I. Hamachi*
Biopolymers-Peptide Science, 76, 177-184 (2004) doi: 10.1002/bip.10574
94. Molecular Recognition in a Supramolecular Hydrogel to Afford a Semi-wet Sensor Chip
I. Yoshimura, Y. Miyahara, N. Kasagi, H. Yamane, A. Ojida, I. Hamachi*
J. Am. Chem. Soc., 126, 12204-12205 (2004) doi: 10.1021/ja045962a
93. Phosphoprotein-Selective Recognition and Staining in SDS-PAGE by Bis-Zn(II)-dipycolylamine-Appended Anthracene
A. Ojida, T. Kohira, I. Hamachi*
Chem. Lett., 33, 1024-1025 (2004) doi: 10.1246/cl.2004.1024
92. Urea-functionalized Resorcinarenes: Preparation, Self-folding, and Their CD Phenomena Caused by Chiral Urea Termini through Intramolecular Hydrogen Bonding Interactions
O. Hayashida*, J. Ito, S. Matsumoto, I. Hamachi*
Chem. Lett., 33, 994-995 (2004) doi: 10.1246/cl.2004.994
91. Fluorophore Appended Saccharide Cyclophane: Self-Association, Fluorescent Properties, Heterodimers with Cyclodextrins, and Cross-Linking Behavior with Peanut Agglutinin of Dansyl-Modified Saccharide Cyclophane
O. Hayashida*, I. Hamachi*
J. Org. Chem., 69, 3509-3516 (2004) doi: 10.1021/jo0496852
90. A FRET Study of Guest Delivery to Concanavaline A by Supramolecular Hosts Composed of an Adamantyl-appended Cyclophane and Saccharide-branched Cyclodextrins
O. Hayashida*, I. Hamachi*
Chem. Lett., 33, 548-549 (2004) doi: 10.1246/cl.2004.548
89. Molecular Recognition and Fluorescence Sensing toward mono-Phosphorylated Peptides in Aqueous Solution by bis(Zn(II)-dipicolylamine)-based Artificial Receptors
A. Ojida, Y. Mito-oka, K. Sada, I. Hamachi*
J. Am. Chem. Soc., 126, 2454-2463 (2004) doi: 10.1021/ja038277x
88. Coupling a Natural Receptor Protein with an Artificial Receptor to Afford a Semisynthetic Fluorescent Biosensor
E. Nakata, T. Nagase, S. Shinkai, I. Hamachi*
J. Am. Chem. Soc., 126, 490-495 (2004) doi: 10.1021/ja035631i
87. Semi-wet Peptide/Protein Array Using Supramolecular Hydrogel
S. Kiyonaka, K. Sada, I. Yoshimura, S. Shinkai, N. Kato, I. Hamachi*
Nat. Mater., 3, 57-64 (2004) doi: 10.1038/nmat1034
86. Cross-Linking Strategy for Molecular Recognition and Fluorescent Sending of a Multi-phosphorylated Peptide in Aqueous Solution
A. Ojida, M. Inoue, Y. Mito-oka, I. Hamachi*
J. Am. Chem. Soc., 125, 10184-10185 (2003) doi: 10.1021/ja036317r
85. Construction of Artifical Signal Transducers on a Lectin Surface by Post-Photoaffinity-Labeling Modification for Fluorescent Sccharide Biosensors
T. Nagase, E. Nakata, S. Shinkai, I. Hamachi*
Chem. -A Euro. J., 9, 3660-3669 (2003) doi: 10.1002/chem.200304925
84. New Supramolecular Approach for Saccharide-directed Chemical Modification of Concanavalin A
O. Hayashida*, I. Hamachi*
Chem. Lett., 32, 632-633 (2003) doi: 10.1246/cl.2003.632
83. Molecular Recognition by Supramolecular Hosts Composed of an Adamanthyl-appended Macrocycle with Cyclodextrins in Water
O. Hayashida*, I. Hamachi*
Chem. Lett., 32, 288-289 (2003) doi: 10.1246/cl.2003.288
82. pH-Responsive Phase Transition of Supramolecular Hydrogel Consisting of Glycosylated Amino Acetate and Carboxylic Acid Derivative
S. Kiyonaka, S-L. Zhou, I. Hamachi*
Supramol. Chem., 15, 521-528 (2003) doi: 10.1080/10610270310001605115
81. Combinatorial Library of Low Molecular Weight Organo-and Hydrogelators Based on Glycosylated Amino Acid Derivatives by Solid Phase Synthesis
S. Kiyonaka, S. Shinkai, I. Hamachi*
Chem. -A Euro. J., 9, 976-983 (2003) doi: 10.1002/chem.200390120
80. Caged RNase: Photoactivation of the Enzyme from Perfect Off-state by Site-specific Incorporation of 2-Nitrobenzyl Moiety
T. Hiraoka, I. Hamachi*
Bioorg. Med. Chem. Lett., 13, 13-15 (2003) doi: 10.1016/S0960-894X(02)00825-9
79. Semisynthetic Hemoproteins Using Cofactor Engineering
S. Tsukiji, I. Hamachi
Supramol.Chem., 14, 133-142 (2002) doi: 10.1080/10610270290026031
78. Site-specific Discrimination by Cyanovirin-N for alfa-Linked Trisaccharides Comprising the Three Arms of Man8 and Man9
C. A. Bewley*, S. Kiyonaka, I. Hamachi
J. Mol. Biol., 322, 881-889 (2002) doi: 10.1016/S0022-2836(02)00842-2
77. Efficient Fluorescent ATP-sensing Based on Coordination Chemistry under Aqueous Neutral Conditions
A. Ojida, S-K Parkm Y. Mito-oka, I. Hamachi*
Tetrahedron Lett., 43, 6193-6195 (2002) doi: 10.1016/S0040-4039(02)01317-5
76. First Thermally Responsive Supramolecular Polymer Based on Glycosylated Amino Acid
S. Kiyonaka, K. Sugiyasu, S. Shinkai, I. Hamachi*
J. Am. Chem. Soc., 124, 10954-10955 (2002) doi: 10.1021/ja027277e
75. First Artificial Receptors and Chemosensors toward Phosphorylated Peptide in Aqueous Solution
A. Ojida, Y. Mito-oka, M. Inoue, I. Hamachi*
J. Am. Chem. Soc., 124, 6256-6258 (2002) doi: 10.1021/ja025761b
74. Incorporation of Artificial Receptors into a Protein/Peptide Surface: a Strategy for On/Off Type of Switching of Semisynthetic Enzymes
I. Hamachi*, J. Watanabe, R. Eboshi, T. Hiraoka, S. Shinkai
Biopolymers 55, 459-468 (2001) doi: 10.1002/1097-0282(2000)
73. Supramolecular Construction of Covalently and Noncovalently-linked Photoinduced Electron Transfer Systems in Myoglobin Scaffold
H. Takashima, Y-Z. Hu, K. Sano, S. , S. Shinkai, S. Oishi, I. Hamachi*
Electorchemistry, 69, 942-945 (2001) doi: 10.5796/electrochemistry.69.942
72. Zn(II) Dipicolylamine-based Artificial Receptor as A New Entry for Surface Recognition of a-Helical Peptides in Aqueous Solution
Y. Mito-oka, S. Tsukiji, T. Hiraoka, N. Kasagi, S. Shinkai, I. Hamachi*
Tetrahedron Lett., 42, 7059-7062 (2001) doi: 10.1016/S0040-4039(01)01408-3
71. Solid-phase Lipid Synthesis (SPLS)-2: Incidental Discovery of Organogelators Based on Artificial Glycolipids
I. Hamachi*, S. Kiyonaka, S. Shinkai
Tetrahedron Lett., 42, 6141-6145 (2001) doi: 10.1016/S0040-4039(01)01013-9
70. Post-Photoaffinity Labeling Modification Using Aldehyde Chemistry to Produce a Fluorescent Lectin toward Sacchariide-Biosensors
T. Nagase, S. Shinkai, I. Hamachi*
Chem. Commun., 229-230 (2001) doi: 10.1039/B008323M
69. Pd(en) as a Sequence-Selective Molecular Pinch for a-Helical Peptides
I. Hamachi*, N. Kasagi, S. Kiyonaka, T. Nagase, Y. Mito-oka, S. Shinkai
Chem. Lett., 16-17 (2001) doi: 10.1246/cl.2001.16
68. A General Semisynthetic Method for Fluorescent Saccharide-Biosensors Based on a Lectin
I. Hamachi*, T. Nagase, S. Shinkai
J. Am. Chem. Soc., 122, 12065-12066 (2000) doi: 10.1021/ja002044d
67. Solid Phase Lipid Synthesis (SPLS) for Construction of an Artificial Glycolipid Library
I. Hamachi*, S. Kiyonaka, S. Shinkai
Chem. Commun., 1281-1282 (2000) doi: 10.1039/B002545N
66. Cyclodextrin-Appended Myoglobin as a Tool for Construction of a Donor-Sensitizer-Acceptor Triad on a Protein Surface
I. Hamachi*, H. Takashima, Y-Z. Hu, S. Shinkai, S. Oishi
Chem. Commun., 1127-1128 (2000) doi: 10.1039/B001997F
65. Direct Comparison of Electron Transfer Properties of Two Distinct Semisynthetic Triads with Non-Protein Based Triad: Unambiguous Experimental Evidences on Protein Matrix Effects
Y-Z. Hu, H. Takashima, S. Tsukiji, S. Shinkai, T. Nagamune, S. Oishi, I. Hamachi*
Chem. -A Euro. J., 6, 1907-1916 (2000) doi: 10.1002/1521-3765(20000602)
64. Novel Saccharide-Induced Conformational Changes in a Boronic Acid-appended Poly(L-Lysine) as Detected by Circular Dichroism and Fluorescence
H. Kobayashi, K. Nakashima, E. Ohshima, Y. Hisaeda, I. Hamachi, S. Shinkai*
J. Chem. Soc., Perkin Trans. 2, 5, 997-1002 (2000) doi: 10.1039/A909822D
63. Guest-Induced Umpolung on a Protein Surface: A Strategy for Regulation of Enzymatic Activity
I. Hamachi*, R. Eboshi, J. Watanabe, S. Shinkai
J. Am. Chem. Soc., 122, 4530-4531 (2000) doi: 10.1021/ja9944857
62. Coupling Covalent and Noncovalent Electron Transfer in a Catename-Type Donor-Sensitizer-Acceptor Triad
Y-Z. Hu, S. Tsukiji, S. Shinkai, S. Oishi, H. Duerr, I. Hamachi*
Chem. Lett., 5, 442-443 (2000) doi: 10.1246/cl.2000.442
61. The Synthesis of a Reconstituted C60-Modified Protein
H. Murakami, Y. Okusa, S. Kiyonaka, I. Hamachi, S. Shinkai, N. Nakashima*
Chem. Lett., 1, 46-47 (2000) doi: 10.1246/cl.2000.46
60. Construction of Artificial Photosynthetic Reaction Centers on a Protein Surface: Vectorial, Multistep, and Proton-Coupled Electron Transfer for Long-Lived Charge Separation
Y-Z. Hu, S. Tsukiji, S. Shinkai, S. Oishi, I. Hamachi*
J. Am. Chem. Soc., 122, 241-253 (2000) doi: 10.1021/ja991406i
59. Incorporation of Artificial Receptors into a Protein/Peptide Surface: A Strategy for on/off Type of Switching of Semisynthetic Enzymes
I. Hamachi*, J.-I. Watanabe, R. Eboshi, T. Hiraoka, S. Shinkai
Biopolymers-Peptide Science Section, 55, 459-468 (2000) doi: 10.1002/1097-0282(2000)
1990 - 1999
1990 - 1999
58. Chemical Modification of Structures and Functions of Proteins by Cofactor Reconstitution Method
I. Hamachi*, S. Shinkai
Eur. J. Org. Chem., 3, 539-549 (1999) doi: 10.1002/(SICI)1099-0690(199903)
57. Ru(bpy)3-Based Artificial Receptors toward a Protein Surface: Selective Binding and Efficient Photoreduction of Cytochrome c
H. Takashima, S. Shinkai, I. Hamachi*
Chem. Commun., 23, 2345-2346 (1999) doi: 10.1039/a907642e
56. Metal-Induced Conformational Changes in Calix[n]arenes Can Control the Electron-Transfer Efficiency between Porphyrin and [60]Fullerene in an On-Off Manner
M. Kawaguchi, A. Ikeda, I. Hamachi, S. Shinkai*
Tetrahedron. Lett., 40, 8245-8249 (1999) doi: 10.1016/S0040-4039(99)01750-5
55. Electron Transfer from Zn-Protoporphyrin IX to Ruthenium Ammine Attached at His63 of Reconstituted Cytochrome b562
I. Hamachi*, H. Takashima, S. Tsukiji, S. Shinkai, T. Nagamune, S. Oishi
Chem. Lett., 7, 551-552 (1999) doi: 10.1246/cl.1999.551
54. Direct Observation of the Ferric-Porphyrin Cation Radical as an Intermediate in the Phototriggered Oxidation of Ferric- to Ferryl-Heme Tethered Ru(bpy)3 in Reconstituted Myoglobin
I. Hamachi*, S. Tsukiji, S. Shinkai, S. Oishi
J. Am. Chem. Soc., 121, 5500-5506 (1999) doi: 10.1021/ja984199f
53. A Convenient Synthesis of a Ru(bpy)3-Based Catenane-Type Triad and Its Incorporation into a Protein Scaffold
Y-Z. Hu, S. Tsukiji, S. Shinkai, I. Hamachi*
Chem. Lett., 6, 517-518 (1999) doi: 10.1246/cl.1999.517
52. Single- or Dual-Mode Switching of Semisynthetic Ribonuclease S' with an Iminodiacetic Acid Moiety in Response to the Copper(II) Concentration
I. Hamachi*, Y. Yamada, T. Matsugi, S. Shinkai
Chem. -A Euro. J., 5, 1503-1511 (1999) doi: 10.1002/(SICI)1521-3765(19990503)
51. Design and Semisynthesis of Spermine-Sensitive Ribonuclease S'
I. Hamachi*, Y. Yamada, R. Eboshi, T. Hiraoka, S. Shinkai
Bioorg. Med. Chem. Lett., 9, 1215-1218 (1999) doi: 10.1016/S0960-894X(99)00189-4
50. Facile Preparation of Robust Organic Gels by Cross-Link of a Sugar-Integrated Gelator by Toluene-2,4-diisocyanate
K. Inoue, Y. Ono, Y. Kanekiyo, S. Kiyonaka, I. Hamachi, S. Shinkai
Chem. Lett., 3, 225-226 (1999)
49. A Boronic Acid-diol Interaction Is Useful for Chiroselective Transcription of the Sugar Structure to the Delta- versus Lamda-[Co(III)(bpy)3]3+ Ratio
T. Mizuno, Takeuchi, I. Hamachi, K. Nakashima, S. Shinkai
J. Chem. Soc., Perkin Trans. 2, 10, 2281-2288 (1998)
48. Design and Semisynthesis of Photo-Active Myoglobin-Bearing Ruthenium Tris(2,2-bipyridine) Using Cofactor-Reconstitution
I. Hamachi, S. Tanaka, S. Tsukiji, S. Shinkai, S. Oishi
Inorg. Chem., 37, 4380-4388 (1998)
47. Photoswiching of the Enzymatic Activity of Semisynthetic Ribonuclease S' Bearing Phenylazophenylalanine at a Specific Site
I. Hamachi, T. Hiraoka, Y. Yamada, S. Shinkai
Chem. Lett., 6, 537-538 (1998)
46. Pyrenylboronic Acids as a Novel Entry for Photochemical DNA Cleavage: Diradical-Forming Pyrene-1,6-diyldiboronic Acid Mimics the Cleavage Mechanism of Enediyne Antitumor Antibiotics
H. Suenaga, K. Nakashima, T. Mizuno, M. Takeuchi, I. Hamachi, S. Shinkai
J. Chem. Soc., Perkin Trans. 1, 7, 1263-1267 (1998)
45. Design and Synthesis of a Transition Metal Responsive Semisynthetic Myoglobin-Bearing Iminodiacetic Acid Moiety
I. Hamachi, T. Matsugi, K. Wakigawa, S. Shinkai
Inorg. Chem., 37, 1592-1597 (1998)
44. Incorporation of an Artificial Receptor into a Native Protein: New Strategy for the Design of Semisynthetic Enzymes with Allosteric Properties
I. Hamachi, T. Nagase, Y. Tajiri, S. Shinkai
Bioconjugate Chem., 8, 862-868 (1997)
43. Protein Engineering Using Molecular Assembly: Functional Conversion of Cytochrome c via Noncovalent Interactions
I. Hamachi, A. Fujita, T. Kunitake
J. Am. Chem. Soc., 119, 9096-9102 (1997)
42. Chiroselective Transcription of the Sugar Structure to D- or L-[CoIII(bpy)3]3+ Using a Boronic Acid-Sugar Template Interaction
T. Mizuno, M. Takeuchi, I. Hamachi, K. Nakashima, S. Shinkai
Chem. Commun., 18, 1793-1794 (1997)
41. Photocontrol of the Redox State of Ruthenium-Tris(bipyridine)-Appended Cytochrome b562
I. Hamachi, S. Tanaka, S. Tsukiji, S. Shinkai, M. Shimizu, T. Nagamune
Chem. Commun., 18, 1735-1736 (1997)
40. Design and Synthesis of Sugar-Responsive Semiartificial Myoglobin Triggered by Modulation of Apoprotein-Cofactor Interactions
I. Hamachi, Y. Tajiri, T. Nagase, S. Shinkai
Chem. -A Euro. J., 3, 1025-1031 (1997)
39. Pyrenylboronic Acid as a Novel Entry for Photochemical DNA Cleavage
H. Suenaga, K. Nakashima, I. Hamachi, S. Shinkai
Tetrahedron Lett., 38, 2479-2482 (1997)
38. A Novel Sugar Sensing System Designed with a Cooperative Action of a Boronic-Acid-Appended Zinc Porphyrin and a 3-Pyridylboronic Acid Axial Ligand
M. Takeuchi, H. Kijima, I. Hamachi, S. Shinkai
Bull. Chem. Soc. Jpn., 70, 699-705 (1997)
37. Sugar-Induced Chiral Orientation of Boronic-Acid-Appended Amphiphile Clusters Formed in the Dipalmitoylphosphatidylcholine (DPPC) Membrane
T. Kimura, M. Takeuchi, I. Hamachi, S. Shinkai
Israel J. Chem., 36, 379-388 (1996)
36. Transition-Metals Facilitated Electron Transfer of Semisynthetic Myoglobin Bearing Bis(iminodiacetic Acid) Moiety
I. Hamachi, T. Matsugi, S. Shinkai
Tetrahedron Lett., 37, 9233-9236 (1996)
35. Sugar-Enhanced Aniline Hydroxylase Activity of Semisynthetic Myoglobins Possessing m-Dihydroxyphenylalanine
I. Hamachi, T. Nagase, Y. Tajiri, S. Shinkai
Chem. Commun., 18, 2205-2206 (1996)
34. Efficient Photogeneration of Oxidizing (Compound II-like) Species of Semisynthetic Myoglobin Appending Ruthenium Tris(2,2'-bipyridine)
I. Hamachi, S. Tsukiji, S. Tanaka, S. Shinkai
Chem. Lett., 9, 751-752 (1996)
33. Facilitated Photoreduction of Ruthenium Bis(4'-methylterpyridine) Pendant Myoglobin
I. Hamachi, T. Matsugi, S. Tanaka, S. Shinkai
Bull. Chem. Soc. Jpn., 69, 1657-1661 (1996)
32. Aniline-Hydroxylase Activity of Myoglobin by Coupling with a Membrane-Bound Electron Transport System
I. Hamachi, A. Fujita, T. Kunitake
Chem. Lett., 8, 657-658 (1995)
31. Peroxidase Activity of Cytochrome c Generated by Phenylboronic Acid Modification
I. Hamachi, O. Kimura, H. Takeshita, S. Shinkai
Chem. Lett., 7, 529-530 (1995)
30. X-ray Crystallographic Studies of a Mn(II)-Bridged Biscalix[4]arene with a Large Inner Cavity
H. Iki, H. Tsuzuki, H. Kijima, I. Hamachi, S. Shinkai
Supramol. Chem., 4, 223-228 (1995)
29. Enhanced N-Demethylase Activity of Cytochrome c Bound to a Phosphate-Bearing Synthetic Bilayer Membrane
I. Hamachi, A. Fujita, T. Kunitake
J. Am. Chem. Soc., 116, 8811-8812 (1994)
28. Novel Chemical Modification of Myoglobin by an Alcohol-Responsive Phenylboronic Acid Function
T. Nagasaki, O. Kimura, I. Hamachi, S. Shinkai
Chem. Lett., 10, 1945-1948 (1994)
27. Sugar-Responsive Semisynthetic Myoglobin Bearing Phenylboronic Acid Groups as Recognition Sites
I. Hamachi, Y. Tajiri, S. Shinkai
J. Am. Chem. Soc., 116, 7437-7438 (1994)
26. Enhanced Peroxidase Activity of Cytochrome c by Phosphate Bilayer Membrane
A. Fujita, H. Senzu, T. Kunitake, I. Hamachi
Chem. Lett., 7, 1219-1232 (1994)
25. Sugar Sensing Utilizing Aggregation Properties of Boronic-Acid-Appended Porphyrins and Metalloporphyrins
H. Murakami, T. Nagasaki, I. Hamachi, S. Shinkai
J. Chem. Soc. Perkin Trans. 2, 975-981 (1994)
24. Self-Sufficient Electron Injection from NADH to the Active Center of Flavin-Pendant Myoglobin
I. Hamachi, K. Nomoto, S. Tanaka, Y. Tajiri, S. Shinkai
Chem. Lett., 6, 1139-1142 (1994)
23. Synthesis, Metal-Binding Properties and Polypeptide Solubilization of 'Crowned' Arborols
T. Nagasaki, O. Kimura, M. Ukon, S. Arimori, I. Hamachi, S. Shinkai
J. Chem. Soc. Perkin Trans. 1, 75-81 (1994)
22. Sugar-Facilitated Incorporation of a Heme Cofactor Bearing Phenylboronic Acid Groups into Apomyoglobin
I. Hamachi, Y. Tajiri, H. Murakami, S. Shinkai
Chem. Lett., 3, 575-578 (1994)
21. Sugar Sensing Utilizing Aggregation Properties of a Boronic-Acid-Appended Porphyrin
H. Murakami, T. Nagasaki, I. Hamachi, S. Shinkai
Tetrahedron Lett., 34, 6273-6276 (1993)
20. Light-Driven Activation of Reconstituted Myoglobin with a Ruthenium Tris(2,2'-bipyridine) Pendant
I. Hamachi, S. Tanaka, S. Shinkai
J. Am. Chem. Soc., 115, 10458-10459 (1993)
19. Energy Transfer from Zinc-Myoglobin to a Cyanine Dye Facilitated by Their Simultaneous Binding to a Phosphate Bilayer Membrane
I. Hamachi, H. Fujimura, T. Kunitake
Chem. Lett., 22, 1551-1554 (1993)
18. Reconstitution of Myoglobin with a Heme Cofactor Bearing a Ruthenium Tris(2,2'-bipyridine) Pendant
I. Hamachi, S. Tanaka, S. Shinkai
Chem. Lett., 22, 1417-1420 (1993)
17. Lipid Anchored Myoglobin 2. Effect of the Anchor Structure on Membrane Binding
I. Hamachi, S. Higuchi, K. Nakamura, H. Fujimura, T. Kunitake
Chem. Lett., 22, 1175-1178 (1993)
16. Anisotropic Incorporation of Lipid-Anchored Myoglobin into a Phospholipid Bilayer Membrane
I. Hamachi, K. Nakamura, A. Fujita, T. Kunitake
J. Am. Chem. Soc., 115, 4966-4970 (1993)
15. Simultaneous Fixation of Orientation of Myoglobin and Metalloporphyrins by Synthetic Bilayer Membrane
I. Hamachi, S. Noda, H. Iwasaki, T. Kunitake
Proc. Japan Acad., 68, 47-50 (1992)
14. Functional Conversion of Myoglobin Bound to Synthetic Bilayer Membranes: From Dioxygen Storage Protein to Redox Enzyme
I. Hamachi, S. Noda, T. Kunitake
J. Am. Chem. Soc., 113, 9625-9630 (1991)
13. Immobilization of Myoglobin in a Multilayer Film of Two-Dimensional Polymer Network
I. Hamachi, H. Fujimura, T. Kunitake,
Chem. Lett., 20, 2227-2230 (1991)
12. A Novel Transmembrane Electron Channel Containing Flavin Units
Y. Kobuke, M. Yamanishi, I. Hamachi, H. Kagawa, H. Ogoshi
J. Chem. Soc., Chem. Commun., 13, 895-897 (1991)
11. Oriented Intercalation of Myoglobin into Multilayered Films of Synthetic Bilayer Membranes
I. Hamachi, T. Honda, S. Noda, T. Kunitake
Chem. Lett., 20, 1121-1124 (1991)
10. Layered Arrangement of Oriented Myoglobins in Cast Films of a Phosphate Bilayer Membrane
I. Hamachi, S. Noda, T. Kunitake
J. Am. Chem. Soc., 112, 6744-6745 (1990)
1980 - 1989
1980 - 1989
9. Coupled Electron-Proton Transport in Flavolipid Functionalized Liposome
Y. Kobuke*, I. Hamachi
J. Chem. Soc., Chem. Commun., 18, 1300-1302 (1989) doi: 10.1039/C39890001300
8. Synthesis of Side-Chain Derivatives of 2,2'-Bipyridine
L. D. Ciana*, I. Hamachi, T. J. Meyer
J. Org. Chem., 54, 1731-1735 (1989) doi: 10.1021/jo00268a042
7. Artificial Flavolipid. Its Synthesis, Incorporation into Liposomal Membrane, Electron Transport, and Successful Control of Transport Rate
I. Tabushi, I. Hamachi, Y. Kobuke*
J. Chem. Soc. Perkin Trans. 1, 383-390 (1989) doi: 10.1039/P19890000383
6. Facilitated Electron Transfer from NADH to Flavolipid Bound in Ammonium Bilayer
I. Hamachi, Y. Kobuke*
J. Chem. Soc., Chem. Commun., 2, 130-131 (1989) doi: 10.1039/C39890000130
5. Efficient Electron Flux Conversion from Strongly Hydrophilic NADH Model in the Transmembrane Electron Transfer by Flavolipid
I. Hamachi, Y. Kobuke, I. Tabushi
Bull. Chem. Soc. Jpn., 61, 3613-3618 (1988) doi: 10.1246/bcsj.61.3613
4. Control of Electron Transport by Thermally Induced Phase Transition of Liposomal Membrane
I. Tabushi, I. Hamachi, Y. Kobuke*
Tetrahedron Lett., 28, 5899-5902 (1987) doi: 10.1016/S0040-4039(01)81085-6
3. Single Wall Bilayer Liposome Functionalized with the Artificial Flavolipid (II): Its Efficient Electron Flux Conversion from NADH Model of an Appropriate Structure in the Transmembrane Electron Transfer
I. Tabushi*, I. Hamachi
Tetrahedron Lett., 28, 3363-3366 (1987) doi: 10.1016/S0040-4039(00)95513-8
2. First Member of Artificial Flavolipid Family, Its Synthesis and Incorporation into Arificial Liposomes
I. Tabushi*, I. Hamachi
Tetrahedron Lett., 27, 5401-5404 (1986) doi: 10.1016/S0040-4039(00)85222-3
1. Erythroselectivity in Addition of g-Substituted Allylsilanes to Aldehydes in the Presence of Titanium Chloride
T. Hayashi*, K. Kabeta, I. Hamachi, M. Kumada*
Tetrahedron Lett., 24, 2865-2868 (1983) doi: 10.1016/S0040-4039(00)88045-4
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