Embedded Files
2020 -
2020 -
338. Click Chemistry for Protein Modification in Live Cells and In Vivo
S. Sakamoto, I. Hamachi*
Topics in Heterocyclic Chemistry, Electronic ISSN 1861-9290 (2026) doi: 10.1007/7081_2025_102
337. Organelle-selective click chemistry for monitoring fatty acid metabolism at the subcellular level
T. Tamura*, S. Kawamoto, I. Hamachi
Methods in Enzymology, 727, 355-371 (2026) doi: 10.1016/bs.mie.2026.01.016
336. Ligand-Directed Self-Assembling Chimeras for Targeted Protein O-GlcNAcylation
Z. Guo, T. Xu, K. S. Khan, S. Scheeff, Y. Qin, S. Yu, R. Lo, Y. Li, Y. Xie, B. Ma, Y. Huang, H. Y. Yip, C. Y. Chung, T. Tamura, I. Hamachi, B. W. Ng*
ACS Chemical Biology, 20, 12, 2907-2916 (2025) doi: 10.1021/acschembio.5c00684
335. Proximity effects leveraged in ligand-directed chemical labeling of natural proteins under live conditions
I. Hamachi, T. Tamura, H. Nonaka
Accounts of Chemical Research, 58, 24, 3592-3602 (2025) doi: 10.1021/acs.accounts.5c00646
334. Lysine-reactive tag system for cell-surface protein labeling via N-acyl-N-alkyl sulfonamide chemistry
V. Thimaradka, T. Tamura*, I. Hamachi*
Bioorganic & Medicinal Chemistry Letters, 131: 130470 (2026) doi: 10.1016/j.bmcl.2025.130470
333. A chemogenetic strategy for inhibiting G protein-coupled receptor activity using metal coordination
T. Doura, T. Sugawara, H. Inoue, M. Tsujikawa, Y. Michibata, I. Hamachi, S. Kiyonaka*
Chemistry Letters, 54, 8, upaf152 (2025) doi: 10.1093/chemle/upaf152
332. N-oxide-driven heme-activatable biomolecule labeling for visualization of labile heme in living cells and mouse brain
R. Kakiuchi, T. Fukaya, S. Tamakoshi, S. Tsuji, H. Fujimori, M. Shimazawa, T. Tamura, I. Hamachi, T. Ochi, H. Matsunaga, H. Takeyama, H. Nagasawa, T. Hirayama*
Journal of the American Chemical Society, 147, 31, 27484-27493 (2025) doi: 10.1021/jacs.5c04990
331. Zinc Conditional Proteomics Using Zinc-responsive Protein Labelling Reagent and Recent Examples of Expansion to Other Biometals
T. Tamura*, I. Hamachi*
Zinc in Biology, 2, 24-39 (2025) doi: 10.1039/9781837676583-00024
330. Subcellular analysis of fatty acid metabolism using organelle-selective click chemistry
T. Kimura, S. Kawamoto, A. Fujisawa, M. Yoshida, Y. Shen, M. Tsuchiya, T. Tamura*, I. Hamachi*
Journal of the American Chemical Society, 147, 26, 22284-22289 (2025) doi: 10.1021/jacs.5c02871
329. Recent advances in proximity labeling for chemical proteomics: paving the way for in vivo applications
F. Y. Tanimura Valor, T. Tamura, I. Hamachi*
Current Opinion in Chemical Biology, 87, 102620 (2025) doi: 10.1016/j.cbpa.2025.102620
328. Rapid and reversible fluorescent probe enables repeated snapshot imaging of AMPA receptors during synaptic plasticity
K. Soga, T. Fujiwara, M. Nakagawa, A. Shibata, H. Adriel, K. Yatsuzuka, W. Kakegawa, M. Yuzaki, I. Hamachi, E. Nango*, S. Kiyonaka*
Science Advances, 11, 23, 2375-2548 (2025) doi: 10.1126/sciadv.adt6683
327. In-brain synthesis of receptor-based protease sensors by coupling ligand-directed chemistry and click chemistry
S. Sakamoto, K. Shiraiwa, M. Wang, M. Ishikawa, H. Nonaka,* I. Hamachi*
Nature Synthesis, 4, 1128-1140 (2025) doi: 10.1038/s44160-025-00815-6
326. Intratumour oxidative hotspots provide a niche for cancer cell dissemination
Y. Ueda, S. Kiyonaka*, L. M. Selfors, K. Inoue, H. Harada, T. Doura, K. Onuma, M. Uchiyama, R. Kurogi, Y. Yamada, J. H. Sun, R. Sakaguchi, Y. Tado, H. Omatsu, H. Suzuki, M. Aoun, T. Nakayama, T. Kajimoto, T. Yano, R. Holmdahl, I. Hamachi, M. Inoue, Y. Mori*, N. Takahashi*
Nature Cell Biology, 27, 530-543 (2025) doi: 10.1038/s41556-025-01617-w
325. Profiling proteins involved in peroxynitrite homeostasis using ROS/RNS conditional proteomics
H. Zhu*, H. Uno, K. Matsuba, I. Hamachi*
Journal of the American Chemical Society, 147, 9, 7305-7316 (2025) doi: 10.1021/jacs.4c14060
324. A Protein Cleavage Platform Based on Selective Formylation at Cysteine Residues
N. Zenmyo, Y. Matsumoto, A. Yasuda, S. Uchinomiya, N. Shindo, K. Sasaki-Tabata, E. Mishiro-Sato, T. Tamura, I. Hamachi, A. Ojida*
Journal of the American Chemical Society, 147, 4, 3080-3091(2025) doi: 10.1021/jacs.4c10991
323. Chromosomal domain formation by archaeal SMC, a roadblock protein, and DNA structure
K. Yamaura, N. Takemata*, M. Kariya, A. Osaka, S. Ishino, M. Yamauchi, T. Tamura, I. Hamachi, S. Takada, Y. Ishino, H. Atomi*
Nature Communications, 16: 1312 (2025) doi: 10.1038/s41467-025-56197-y
322. Conversion of silent synapses to AMPA receptor-mediated functional synapses in human cortical organoids
M. Nishimura, T. Kodera, S. Adachi, A. Y. Sato, R. F. Takeuchi, H. Nonaka, I. Hamachi, F. Osakada*
Neuroscience Research, 212, 20-30 (2025) doi: 10.1016/j.neures.2024.12.008
321. Thoughts for the future
L. M. Alkhalaf, C. Arrowsmith, E. P. Balskus, G. Bergamini, R. Bhandari, C. J. Chang, P. Chen, X. Chen, A. Ciulli, J. A. Cricco, B. G. Davis, M. Delbianco, N. Dudareva, E. Dueber, F. Ferguson, P. O. Giuseppe, I. Hamachi, M. C. Hammond, S. K. Hatzios, W. D. Heo, J. P. Janet, S. S. Kamat, S. Knapp, Y. Krishnan, K. Lang, L. Laraia, R. B. Leveson-Gower, X. D. Li, D. R. Liu, M. Liu, N. London, N. Mahanta, C. Mayor-Ruiz, T. Muir, M. T. Murakami, H. Rhee, M. Robers, A. Satz, B. A. Schulman, B. Shen, B. Shoichet, E. Strauss, T. Suzuki, P. Tiwary, H. Waldmann, T. R. Ward, A. Weeks, E. Weerapana, G. Winter
Nature Chemical Biology, 21, 6-15 (2025) doi:10.1038/s41589-024-01802-2
320. Selective Labeling of Phosphatidylcholine to Track Their Translocation Between Organelles in Living Cells
T. Tamura*, I. Hamachi*
Intracellular Lipid Transport, 1, 1-11 (2024) eBook ISBN 978-1-0716-4318-1
319. Targeted covalent modification strategies for drugging the undruggable targets
T. Tamura*, M. Kawano, I. Hamachi*
Chemical Reviews, 125, 2, 1191-1253 (2025) doi: 10.1021/acs.chemrev.4c00745
318. N-acyl-N-alkyl/aryl sulfonamide chemistry assisted by proximity for modification and covalent inhibition of endogenous proteins in living systems
T. Tamura*, I. Hamachi*
Accounts of Chemical Research, 58, 1, 87-100 (2025) doi: 10.1021/acs.accounts.4c00628
317. P2Y12 receptor ligands enable design of fluorescent imaging probes for microglia
H. Nonaka,* M. Wang, I. Hamachi*
Chemistry Letters, 53, 10, upae185 (2024) doi: 10.1093/chemle/upae185
316. Photoproximity labeling of endogenous receptors in the live mouse brain in minutes
M. Takato, S. Sakamoto, H. Nonaka, F. Y. Tanimura Valor, T. Tamura*, I. Hamachi*
Nature Chemical Biology, 21, 109-119 (2025) doi: 10.1038/s41589-024-01692-4
315. Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging
T. Mino, H. Nonaka, I. Hamachi*
Current Opinion in Chemical Biology, 81, 102474 (2024) doi: 10.1016/j.cbpa.2024.102474
314. Protein-labeling reagents selectively activated by copper(I)
R. Cheng, Y. Nishikawa, T. Wagatsuma, T. Kambe, Y. Tanaka, Y. Ogra, T. Tamura*, I. Hamachi*
ACS Chemical Biology, 19, 6, 1222-1228 (2024) doi: 10.1021/acschembio.4c00011
313. Post-click labeling enables highly accurate single cell analyses of glucose uptake ex vivo and in vivo
M. Tsuchiya*, N. Tachibana, I. Hamachi*
Communications Biology, 7: 459 (2024) doi: 10.1038/s42003-024-06164-y
312. Tyrosinase-based proximity labeling in living cells and in vivo
H. Zhu*, J. H. Oh, Y. Matsuda, T. Mino, M. Ishikawa, H. Nakamura, M. Tsujikawa, H. Nonaka, I. Hamachi*
Journal of the American Chemical Society, 146,11,7515-7523 (2024) doi: 10.1021/jacs.3c13183
311. Emergence of dynamic instability by hybridizing synthetic self-assembled dipeptide fibers with surfactant micelles
S. Torigoe, K. Nagao, R. Kubota*, I. Hamachi*
Journal of the American Chemical Society, 146, 9, 5799–5805 (2024) doi: 10.1021/jacs.3c14565
310. Bioorthogonal chemical labeling of endogenous neurotransmitter receptors in living mouse brains
H. Nonaka, S. Sakamoto, K. Shiraiwa, M. Ishikawa, T. Tamura, K. Okuno, T. Kondo, S. Kiyonaka, E. A. Susaki, C. Shimizu, H. R. Ueda, W. Kakegawa, I. Arai, M. Yuzaki, I. Hamachi*
Proceeding of National Academy of Science of USA, 121, 6: 2313887121 (2024) doi: 10.1073/pnas.2313887121
309. Naturally occurring quercetin and myricetin as potent inhibitors for Äb01 human ectonucleotide pyrophosphatase/phosphodiesterase 1
P. Duangiad, B. Nutho, T. Chaijarasphong, N. P. Morales, T. Pongtharangkul, I. Hamachi, A. Ojida, J. Wongkongkatep*
Scientific Reports, 14: 125 (2024) doi: 10.1038/s41598-023-50590-7
308. Lysine-reactive N-acyl-N-aryl sulfonamide warheads: Improved reaction properties and application in the covalent inhibition of an ibrutinib-resistant BTK mutant
M. Kawano, S. Murakawa, K. Higashiguchi, K. Matsuda, T. Tamura*, I. Hamachi*
Journal of the American Chemical Society, 145, 48, 26202–26212 (2023) doi: 10.1021/jacs.3c08740
307. Cell-Like Synthetic Supramolecular Soft Materials Realized in Multicomponent, Non-/Out-of-Equilibrium Dynamic Systems
R. Kubota*, I. Hamachi*
Advanced Science, 2806830 (2023) doi:10.1002/advs.202306830 open access
306. Protocol to visualize the distribution of exogenously administered small molecules in the mouse brain
T. Mino, H. Nonaka, S. Sakamoto, J. H. Oh, I. Hamachi*
STAR Protocols, 4,3,102555(2023) doi:10.1016/j.xpro.2023.102555
305. Visualizing formation and dynamics of a three-dimensional sponge-like network of a coacervate in real time
R. Kubota*, T. Hiroi, Y. Ikuta, Y. Liu, I. Hamachi*
Journal of the American Chemical Society, 145, 33, 18316-18328 (2023) doi:10.1021/jacs.3c03793
304. Flow cytometric analysis of phosphatidylcholine metabolism using organelle-selective click labeling
M. Tsuchiya*, N. Tachibana, I. Hamachi*
STAR Protocols, 4,3,102525(2023) doi:10.1016/j.xpro.2023.102525
303. Coronaridine congeners induce sedative and anxiolytic-like activity in naive and stressed/anxious mice by allosteric mechanisms involving increased GABAA receptor affinity for GABA
H. R. Arias, P. D. Deurwaerdère, P. Scholze, S. Sakamoto, I. Hamachi, G. D. Giovanni, A. Chagraoui
European Journal of Pharmacology, 953: 175854 (2023) doi: 10.1016/j.ejphar.2023.175854
302. Endogenous cell-surface receptor modification by metal chelation-assisted pyridinium oxime catalyst
V. Thimaradka, H. Utsunomiya, T. Tamura*, I. Hamachi*
Organic Letters, 25, 12, 2118-2122 (2023) doi:10.1021/acs.orglett.3c00541
301. Four distinct network patterns of supramolecular/polymer composite hydrogels controlled by formation kinetics and interfiber interactions
K. Nakamura, R. Kubota*, T. Aoyama, K. Urayama, I. Hamachi*
Nature Communications, 14: 1696 (2023) doi:10.1038/s41467-023-37412-0
300. Organelle-selective click labeling coupled with flow cytometry allows pooled CRISPR screening of genes involved in phosphatidylcholine metabolism
M. Tsuchiya, N. Tachibana, K. Nagao, T. Tamura*, I. Hamachi*
Cell Metabolism, 35, 6, 1072-1083 (2023) doi:10.1016/j.cmet.2023.02.014
299. Ligand-directed chemistry for protein labeling for affinity-based protein analysis
S. Sakamoto, I. Hamachi*
Israel Journal of Chemistry, e202200077 (2023) doi: 10.1002/ijch.202200077
298. Recent progress of subcellular-compartment-focused chemical proteomics
L. Wang, H. Nonaka, I. Hamachi
Advances in Chemical Proteomics, 217-247 (2022) doi: 10.1016/B978-0-12-821433-6.00006-4
297. Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes
H. Nonaka, T. Mino, S. Sakamoto, J. H. Oh, Y. Watanabe, M. Ishikawa, A. Tsushima, K. Amaike, S. Kiyonaka, T. Tamura, A. R. Aricescu, W. Kakegawa, E. Miura, M. Yuzaki, I. Hamachi*
Chem, 9, 2, 523-540 (2023) doi:10.1016/j.chempr.2022.11.005
296. Chemical, Pharmacological, and Structural Characterization of Novel Acrylamide-Derived Modulators of the GABAA Receptor
H. R. Arias*, S. R. Pierce, A. L. Germann, S. Q. Xu, M. O. Ortells, S. Sakamoto, D. Manetti, M. Novella R., I. Hamachi, G. Akk
Molecular Pharmacology, 104, 115(2023) doi: 10.1124/molpharm.123.000692
295. Fluorescence identification of arthropathic calcium pyrophosphate single crystals using alizarin red S and a xanthene dipicolylamine ZnII complex
W. Srinarawat, R. Hemstapat, T. Tawonsawatruk, N. Patikarnmonthon, I. Hamachi, A. Ojida and J. Wongkongkatep
Analyst, 147, 21, 4910-4918 (2022) doi:10.1039/D2AN01257J
294. Modulation of the mammalian GABAA receptor by type I and type II positive allosteric modulators of the α7 nicotinic acetylcholine receptor
H. R. Arias, A. L. Germann, S. R. Pierce, S. Sakamoto, M. O. Ortells, I. Hamachi, G. Akk
British Journal of Pharmacology, 179, 24, 5323-5337 (2022) doi:10.1111/bph.15948
293. Light-induced stabilization of microtubules by photo-crosslinking of Tau-derived peptide
S. Watari, H. Inaba, T. Tamura, A. Md. R. Kabir, A. Kakugo, K. Sada, I. Hamachi, K. Matsuura
Chemical Communications , 58, 9190 - 9193 (2022) doi:10.1039/D2CC01890J
292. Temporal stimulus patterns drive differentiation of a synthetic dipeptide-based coacervate
R. Kubota*, S. Torigoe, I. Hamachi*
Journal of the American Chemical Society , 144, 33, 15155-15164 (2022) doi:10.1021/jacs.2c05101
291. Chemical biology tools for imaging-based analysis of organelle membranes and lipids
T. Tamura, I. Hamachi
Current Opinion in Chemical Biology , 70: 102182 (2022) doi: 10.1016/j.cbpa.2022.102182
290. Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue
K. Ojima, W. Kakegawa, T. Yamasaki, Y. Miura, M. Itoh, Y. Michibata, R. Kubota, T. Doura, E. Miura, H. Nonaka, S. Mizuno, S. Takahashi, M. Yuzaki*, I. Hamachi*, S. Kiyonaka*
Nature Communications , 13, 3167 (2022) doi:10.1101/2021.10.01.462737
289. Orthogonal activation of metabotropic glutamate receptor using coordination chemogenetics
A. Senoo, Y. Yamada, K. Ojima, T. Doura, I. Hamachi, S. Kiyonaka
Frontiers in Chemistry , 9, 825669 (2022) doi:10.3389/fchem.2021.825669
288. Extracellular ATP limits homeostatic T cell migration within lymph nodes
D. Kobayashi, Y. Sugiura, E. Umemoto, A. Takeda, H. Ueta, H. Hayasaka, S. Matsuzaki, T. Katakai, M. Suematsu, I. Hamachi, G. G Yegutkin, M. Salmi, S. Jalkanen, M. Miyasaka
Frontiers in Immunology, 12 (2021) doi:10.3389/fimmu.2021.786595
287. Photo-triggered spatially controlled out-of-equilibrium patterns of peptide nanofibers in a self-sorting double network hydrogel
K. Nakamura, W. Tanaka, K. Sada, R. Kubota, T. Aoyama, K. Urayama, I. Hamachi
Journal of the American Chemical Society, 143, 46, 19532–19541(2021) doi:10.1021/jacs.1c09172
286. Organelle-selective labeling of choline-containing phospholipids(CPLs) and real-time imaging in living cells
M. Tsuchiya, T. Tamura, I. Hamachi*
Current Protocols , e105, Volume 1 (2021) doi: 10.1002/cpz1.105
285. Recent applications of N-acyl imidazole chemistry in chemical biology
T. Mino, S. Sakamoto, I. Hamachi*
Bioscience, Biotechnology, and Biochemistry , 85, 1, 53-60 (2021) doi:10.1093/bbb/zbaa026
284. Voices of chemical biology
B. Davis, K. Backus, G. Winter, R. Chica, D. Li, S. Lee, C. He, A. Weeks, C. Overall, S. Hagihara, B. Thuronyi, S. Kamat, L. Chen, R. HurtadoGuerrero, S. Yao, L. Mahal, C. Voigt, C. Woo, E. Strauss, K. Kikuchi, T. Dore, S. Radford, X. Li, W. Heo, G. S. Furga, T. Deans, V. Belousov, M. Matthews, C. Jackson, S. Malek, H. Waldmann, A. Rising, M. Jewett, D. Stamou, E. Parker, M. Murakami, K. Polizzi, I. Hamachi, T. Erb, C. Joo, M. Uesugi, R. Prinjha, G. Rechavi, R. Solano, B. Schulman, Y. David, R. Oslund
Nature Chemical Biology , 17, 1-4 (2021) doi:10.1038/s41589-020-00714-1
283. Microscopic Imaging Techniques for Molecular Assemblies: Electron, Atomic Force, and Confocal Microscopies
R. Kubota, W. Tanaka, I. Hamachi*
Chemical Reviews, 121, 22, 14281-14347 (2021) doi:10.1021/acs.chemrev.0c01334
282. Enhanced Suppression of a Protein–Protein Interaction in Cells Using Small-Molecule Covalent Inhibitors Based on an N-Acyl-N-alkyl Sulfonamide Warhead
T. Ueda, T. Tamura, M. Kawano, K. Shiono, F. Hobor, A. J. Wilson, and I. Hamachi*
Journal of the American Chemical Society , 143, 12, 4766–4774(2021) doi.org/10.1021/jacs.1c00703
281. Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking
K. Ojima, K. Shiraiwa, T. Doura, M. Takato, K. Komatsu, M. Yuzaki, I. Hamachi*, S. Kiyonaka*
Nature Communications , 12:831 (2021) doi:10.1038/s41467-021-21082-x
280. Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent
V. Thimaradka, J. H. Oh, C. Heroven, A. R. Aricescu, M. Yuzaki, T. Tamura*, I. Hamachi*
Bioorganic & Medicinal Chemistry, , 30, 115947(2021) doi:10.1016/j.bmc.2020.115947
279. Fluorescence imaging of drug target proteins using chemical probes
H. Zhu, I. Hamachi*
Journal of Pharmaceutical Analysis , 10, 5, 426-433 (2020) doi:10.1016/j.jpha.2020.05.013
278. Chemical Tools for Endogenous Protein Labeling and Profiling
K. Shiraiwa, R. Cheng, H. Nonaka, T. Tamura, and I. Hamachi*
Cell Chemical Biology , 27, 8, 970-985(2020) doi:10.1016/j.chembio|.2020.06016
277. In Situ Real-time Confocal Imaging of a Self-assembling Peptide-grafted Polymer Showing pH-responsive Hydrogelation
R. Kubota, S. Torigoe, S. Liu, & I. Hamachi*
Chemistry Letters , 49, 11, 1319-1323(2020) doi:10.1246/cl.200513
276. Organelle membrane-specific chemical labeling and dynamic imaging in living cells
T. Tamura, A. Fujisawa, M. Tsuchiya, Y. Shen, K. Nagao, S. Kawano, Y. Tamura, T. Endo, M. Umeda & I. Hamachi*
Nature Chemical Biology , 16, 12, 1361-1367(2020) doi:10.1038/s41589-020-00651-z
275. Imaging and profiling of proteins under oxidative conditions in cells and tissues by hydrogen-peroxide-responsive labeling
H. Zhu, T. Tamura, A. Fujisawa, Y. Nishikawa, R. Cheng, M. Takato, and I. Hamachi*
Journal of the American Chemical Society , 142, 37, 15711–15721(2020) doi:10.1021/jacs.0c02547
274. Control of seed formation allows two distinct self-sorting patterns of supramolecular nanofibers
R. Kubota, K. Nagao, W. Tanaka, R. Matumura, T. Aoyama, K. Urayama and I. Hamachi*
Nature Communications , 11: 4100(2020) doi:10.1038/s41467-020-17984-x
273. Activity-Based Sensing with a Metal-Directed Acyl Imidazole Strategy Reveals Cell Type-Dependent Pools of Labile Brain Copper
S. Lee, Y. S. C. Chung, P. Liu, L. Craciun, Y. Nishikawa, K. Bruemmer, I. Hamachi, K. Saijo, E. Miller, C. Chang*
Journal of the American Chemical Society , 142, 35, 14993–15003(2020) doi:10.1021/jacs.0c05727
272. Protein-Responsive Protein-Release of Supramolecular/polymer Hydrogel Composite Integrating Enzyme Activation Systems
H. Shigemitsu, R. Kubota, K. Nakamura, T. Matsuzaki, S. Minami, T. Aoyama, K. Urayama and I. Hamachi*
Nature Communications , 11: 3859(2020) doi:10.1038/s41467-020-17698-0
271. Force generation by a propagating wave of supramolecular nanofibers
R. Kubota, M. Makuta, R. Suzuki, M. Ichikawa, M. Tanaka and I. Hamachi*
Nature Communications, 11: 3541(2020) doi:10.1038/s41467-020-17394-z
270. Fluorescence determination of soluble pyrophosphate levels in synovial fluid as a marker of pseudogout using middle point of quantification concept and molecular sensor
N. Yongwattana, N. Mekjinda, W. Thepsing, S. Ounsuk, P. Wongkongkatep, T. Tawonsawatruk, I. Hamachi, A. Ojida, J. Wongkongkatep*
Science Asia , 46, 36-42 (2020) doi:10.2306/scienceasia1513-1874.2020.S005
269. Fluorescence Differentiation of ATP-Related Multiple Enzymatic Activities in Synovial Fluid as a Marker of Calcium Pyrophosphate Deposition Disease Using Kyoto Green
N. Yongwattana, N. Mekjinda,T. Tawonsawatruk, I. Hamachi, A. Ojida and J. Wongkongkatep*
molecules, 25, 1116 (2020) doi:10.3390/molecules25051116
268. Screening of protein-ligand interactions under crude conditions by native mass spectrometry
K. Takano, S. Arai, S. Sakamoto, H. Ushijima, T. Ikegami, K. Saikusa, T. Konuma, I. Hamachi, S. Akashi
Analytical and Bioanalytical Chemistry , 412, 4037-4043 (2020) doi:10.1007/s00216-020-02649-x
267. Masking Phosphate with Rare-Earth Elements Enables Selective Detection of Arsenate by Dipycolylamine-ZnII Chemosensor
N. Mekjinda, S. Phunnarungsi, V. Ruangpornvisuti, R. Ritchie, I. Hamachi, A. Ojida, J. Wongkongkatep
Scientific Reports , 10:2656 (2020) doi:10.1038/s41598-020-59585-0
266. Development of a Photoactivatable Proximity Labeling Method for the Identification of Nuclear Proteins
T. Tamura*, M. Takato, K. Shiono, I. Hamachi*
Chemistry Letters , 49, 145-148 (2020) doi:10.1246/cl.190804
265. The Power of Confocal Laser Scanning Microscopy in Supramolecular Chemistry: In situ Real‐time Imaging of Stimuli‐Responsive Multicomponent Supramolecular Hydrogels
R. Kubota, K. Nakamura, S. Torigoe, I. Hamachi
ChemistryOPEN , 9,67-79 (2020) doi:10.1002/open.201900328
264. Development of a cell-based ligand-screening system for identifying Hsp90 inhibitors
T. Ueda, T. Tamura*, I. Hamachi*
Biochemistry , 59, 2, 179-182 (2020) doi:10.1021/acs.biochem.9b00781
2010 - 2019
2010 - 2019
263. Electron Microscopic Detection of Single Membrane Proteins by a Specific Chemical Labeling
S. Tabata, M. Jevtic, N. Kurashige, H. Fuchida, M. Kido, K. Tani, N. Zenmyo, S. Uchinomiya, H. Harada, M. Itakura, I. Hamachi, R. Shigemoto, A. Ojida
iScience , 22, 256-268 (2019) doi:10.1016/j.isci.2019.11.025
262. pH Nanosensor Using Electronic Spins in Diamond
T. Fujisaku, R. Tanabe, S. Onoda, R. Kubota, T. F. Segawa, F. T.-K. So, T. Ohshima, I. Hamachi, M. Shirakawa, R. Igarashi*
ACS Nano , 13, 10, 11726-11732 (2019) doi:10.1021/acsnano.9b05342
261. Construction of a Fluorescent Screening System of Allosteric Modulators for the GABAA Receptor Using a Turn-On Probe
S. Sakamoto, K. Yamaura, T. Numata, F. Harada, K. Amaike, R. Inoue, S. Kiyonaka, I. Hamachi
ACS Central Science , 5, 9, 1541-1553 (2019) doi:10.1021/acscentsci.9b00539
260. On-cell coordination chemistry: Chemogenetic activation of membrane-bound glutamate receptors in living cells
R. Kubota, S. Kiyonaka, I. Hamachi
Methods in Enzymology , 622, 411-430 (2019) doi: 10.1016/bs.mie.2019.02.033
259. Optimized Reaction Pair of the CysHis Tag and Ni(II)-NTA Probe for Highly Selective Chemical Labeling of Membrane Proteins
N. Zenmyo, H. Tokumaru, S. Uchinomiya, H. Fuchida, S. Tabata, I. Hamachi, R. Shigemoto, A. Ojida*
Bulletin of the Chemical Society of Japan , 92, 995-1000 (2019) doi:10.1246/bcsj.20190034
258. Post-assembly fabrication of a functional multicomponent supramolecular hydrogel based on a self-sorting double network
W. Tanaka, H. Shigemitsu, T. Fujisaku, R. Kubota, S. Minami, K. Urayama, I. Hamachi
Journal of the American Chemical Society , 141, 12, 4997–5004 (2019) doi: 10.1021/jacs.9b00715
257. Construction of ligand assay systems by protein-based semisynthetic biosensors
S. Sakamoto, S. Kiyonaka, I. Hamachi
Current Opinion in Chemical Biology , 50, 10-18 (2019) doi:10.1016/j.cbpa.2019.02.011
256. Development of a nitric oxide-responsive labeling reagent for proteome analysis of live cells
Y. Nishikawa, T. Miki, M. Awa, K. Kuwata, T. Tamura, I. Hamachi
ACS Chemical Biology , 14, 3, 397–404 (2019) doi: 10.1021/acschembio.8b01021
255. Selective and reversible modification of kinase cysteines with chlorofluoroacetamides
N. Shindo, H. Fuchida, M. Sato, K. Watari, T. Shibata, K. Kuwata, C. Miura, K. Okamoto, Y. Hatsuyama, K. Tokunaga, S. Sakamoto, S. Morimoto, Y. Abe, M. Shiroishi, J. M. M. Caaveiro, T. Ueda, T. Tamura, N. Matsunaga, T. Nakao, S. Koyanagi, S. Ohdo, Y. Yamaguchi, I. Hamachi, M. Ono, A. Ojida
Nature Chemical Biology (2019) doi: 10.1038/s41589-018-0204-3
254. Recent Progress in Chemical Modification of Proteins
S. Sakamoto, I. Hamachi
Analytical Sciences, 35, 1, 5-27 (2019) doi:10.2116/analsci.18R003
253. Ligand-Directed N-Sulfonyl Pyridone Chemistry for Selective Native Protein Labeling and Imaging in Live Cell
M. Masuda, K. Matsuo, I. Hamachi
Methods in Molecular Biology, 2008, 203-224 (2019) doi: 10.1007/978-1-4939-9537-0_16
252. Chemistry for Covalent Modification of Endogenous/Native Proteins: From Test Tubes to Complex Biological Systems
T. Tamura, I. Hamachi
Journal of the American Chemical Society, 141, 7, 2782–2799 (2019) doi: 10.1021/jacs.8b11747
251. Chemical profiling of the endoplasmic reticulum proteome using designer labeling reagents
A. Fujisawa, T. Tamura, Y. Yasueda, K. Kuwata, I. Hamachi
Journal of the American Chemical Society, 140, 49, 17060-17070(2018)
250. Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons
H. T. T. Ha, S. Leal-Ortiz, K. Lalwani, S. Kiyonaka, I. Hamachi, S. P. Mysore, J. M. Montgomery, C. C. Garner*, J. R. Huguenard*, S. A. Kim*
Frontiers in molecular neuroscience, 11, 405 (2018) doi:10.3389/fnmol.2018.00405
249. Molecular Technologies in Life Innovation:Novel Molecular Technologies for Labeling and Functional Control of Proteins Under Live Cell Conditions
I. Hamachi, S. Kiyonaka, T. Tamura, R. Kubota
Molecular Technology vol.2, 297-328 (2018)
248. Chemogenetic Approach Using Ni(II) Complex–Agonist Conjugates Allows Selective Activation of Class A G-Protein-Coupled Receptors
R. Kubota, W. Nomura, T. Iwasaka, K. Ojima, S. Kiyonaka, I. Hamachi
ACS Central Science, 4, 9, 1211–1221(2018)
247. Chemical Proteomics for Subcellular Proteome Analysis
H. Zhu, T. Tamura, I. Hamachi
Current opinion in chemical biology,48, 1-7 (2019)
246. Imaging-based study on control factors over self-sorting of supramolecular nanofibers formed from peptide- and lipid-type hydrogelators
R. Kubota, S. Liu, H. Shigemitsu, K. Nakamura, W. Tanaka, M. Ikeda, I. Hamachi
Bioconjugate Chemistry, 29, 6, 2058–2067(2018)
245. Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-acyl-N-alkyl sulfonamide
T. Tamura, T. Ueda, T. Goto, T. Tsukidate, Y. Shapira, Y. Nishikawa, A. Fujisawa, I. Hamachi*
Nature Communications, 9, 1870 (2018)
244. Graftable SCoMPIs enable the labeling and X-Ray fluorescence imaging of proteins
S. Hostachy, M. Masuda, T. Miki, I. Hamachi, S. Sagan, O. Lequin, K. Medjoubi, A. Somogyi, N. Delsuc*, C. Policar*
Chemical Science, 9, 4483-4487 (2018)
243. In situ Construction of Protein-based Semisynthetic Biosensors
T. Ueda, T. Tamura, I. Hamachi
ACS Sensors, 3, 527-539 (2018)
242. Endogenous membrane receptors labeling by reactive cytokines/growth factors to chase their dynamics in live cells
Y. Takaoka, S. Uchinomiya, D. Kobayashi, M. Endo, T. Hayashi, Y. Fukuyama, H. Hayasaka, M. Miyasaka, T. Ueda, I. Shimada, I. Hamachi
Chem, 4, 1-14 (2018)
241. Ligand-directed chemistry of AMPA receptors confers live-cell fluorescent biosensors
S. Kiyonaka*, S. Sakamoto, S. Wakayama,Y. Morikawa, M. Tsujikawa, I. Hamachi*
ACS Chemical Biology, 13,7,1880–1889(2018)
240. An adaptive supramolecular hydrogel comprising self-sorting double nanofibre networks
H. Shigemitsu, T. Fujisaku, W. Tanaka, R. Kubota, S. Minami, K. Urayama, I. Hamachi*
Nature Nanotechnology, 13, 165-172 (2018)
239. Live-cell Protein Sulfonylation Based on Proximity-driven N-Sulfonyl Pyridone Chemistry
K. Matsuo, Y. Nishikawa, M. Masuda, I. Hamachi*
Angewandte Chemie International Edition, 15, 659-662 (2018)
238. In Situ Protein Labeling in Complex Environments
T. Tamura, H. Shigemitsu, I. Hamachi
Comprehensive Supramolecular Chemistry II, 409–437. Oxford: Elsevier. (2017)
237. Ligand-Directed Tosyl and Acyl Imidazole Chemisrty
K. Matsuo, I. Hamachi
Chemoselective and Bioorthogonal Ligation Reactions: Concepts and Applications, (Chapter 6)147-163 (2017)
236. Recognition-driven chemical labeling of endogenous proteins in multi-molecular crowding live cells
K. Amaike, T. Tamura, I. Hamachi*
Chem. Commun. Feature Article, 53, 11972-11983 (2017)
235. Affinity-guided oxime chemistry for selective protein acylation in live tissue systems
T. Tamura, Z. Song, K. Amaike, S. Lee, S. Yin, S. Kiyonaka, I. Hamachi*
J. Am. Chem. Soc., 139, 14181-14191 (2017)
234. A host-guest system based on collagen-like triple-helix hybridization
N. Delsuc, S. Uchinomiya, A. Ojida, I. Hamachi
Chem. Commun., 53, 6856-6859 (2017)
233. Chemical labeling for visualizing native AMPA receptors in live neurons
S. Wakayama, S. Kiyonaka*, I. Arai, W. Kakegawa, S. Matsuda, K. Ibata, Y. L. Nemoto, A. Kusumi, M. Yuzaki, I. Hamachi*
Nat. Commun., 8, 14850 (2017)
232. Construction of Protein-Based Biosensors Using Ligand-Directed Chemistry for Detecting Analyte Binding
K. Yamaura, S. Kiyonaka, I. Hamachi
Methods Enzymol., 589, 253-280 (2017)
231. Design strategies of stimuli-responsive supramolecular hydrogels relied on structural analyses and cell-mimicking approaches
H. Shigemitsu, I. Hamachi
Acc. Chem. Res., 50, 740-750 (2017)
230. Fluorescence sensing of inorganic phosphate and pyrophosphate using small molecular sensors and their applications
J. Wongkongkatep, A. Ojida, I. Hamachi
Top. Curr. Chem., 375, 30 (2017)
229. A conditional proteomics approach to identify proteins involved in zinc homeostasis
T. Miki, M. Awa, Y. Nishikawa, S. Kiyonaka, M. Wakabayashi, Y. Ishihama, I. Hamachi*
Nat. Methods, 13, 931-937 (2016)
228. A set of organelle-localizable reactive molecules for mitochondrial chemical proteomics in living cells and brain tissues
Y. Yasueda, T. Tamura, A. Fujisawa, K. Kuwata, S. Tsukiji, S. Kiyonaka, I. Hamachi*
J. Am. Chem. Soc., 138, 7592-7602 (2016)
227. Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells
S. Kiyonaka*, R. Kubota, Y. Michibata, M. Sakakura, H. Takahashi, T. Numata, R. Inoue, M. Yuzaki, I. Hamachi*
Nat. Chem., 8, 958–967 (2016)
226. Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry
K. Yamaura, S. Kiyonaka*, T. Numata, R. Inoue, I. Hamachi*
Nat. Chem. Biol., 12, 822-830 (2016)
225. Preparation of supramolecular hydrogel–enzyme hybrids exhibiting biomolecule-responsive gel degradation
H. Shigemitsu, T. Fujisaku, S. Onogi, T. Yoshii, M. Ikeda, I. Hamachi*
Nat. Protoc., 11, 1744-1756 (2016)
224. In situ real-time imaging of self-sorted supramolecular nanofibres
S. Onogi, H. Shigemitsu, T. Yoshii, T. Tanida, M. Ikeda, R. Kubota, I. Hamachi*
Nat. Chem., 8, 743-752 (2016)
223. Nucleus-selective Chemical Proteomics Using Hoechst-tagged Reactive Molecules
Y. Yasueda, T. Tamura, I. Hamachi*
Chem. Lett., 45, 265-267 (2016)
222. Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function
J. Khoory, J. Estanislau, A. Elkhal, A. Lazaar, M. I. Melhorn, A. Brodsky, B. Illigens, I. Hamachi, Y. Kurishita, A. RIvanov, S. Shevkoplyas, N. I. Shapiro, I. C. Ghiran
PloS one, 11, 1 (2016)
221. Validating Subcellular Thermal Changes Revealed by Fluorescent Thermosensors
S. Kiyonaka, R. Sakaguchi, I. Hamachi, T. Morii, T. Yoshizaki, Y. Mori
Nature Methods, 12, 801-802 (2015)
220. Biomembrane-embedded Catalysts for Membrane-associated Protein Labeling on Red Blood Cells
Y. Yasueda, T. Tamura, K. Kuwata, Y. Takaoka, I. Hamachi*
Chem. Lett., 44, 1673-1675 (2015)
219. Supramolecular Assemblies Responsive to Biomolecules toward Biological Applications
H. Shigemitsu, I. Hamachi*
Chem. Asian J., 10, 2026-2038 (2015)
218. Design of Coordination Interaction of Zn(II) Complex with Oligo-Aspartate Peptide to Afford a High-Affinity Tag-Probe Pair
H. Fuchida, S. Tabata, N. Shindo, I. Takashima, Q. Leng, Y. Hatsuyama, I. Hamachi, A. Ojida*
Bull. Chem. Soc. Jpn., 88, 784-791 (2015)
217. Analysis of Cell-surface Receptor Dynamics Through Covalent Labeling by Catalyst-tethered Antibody
T. Hayashi, Y. Yasueda, T. Tamura, Y. Takaoka, I. Hamachi*
J. Am. Chem. Soc., 137, 3360-3365 (2015)
216. Protein Recognition with Synthetic Small-molecular Binders toward Optical Protein Sensing in Vitro and in Live Cells
R. Kubota, I. Hamachi*
Chem. Soc. Rev., 44, 4454 - 4471 (2015)
215. Ligand-directed Dibromophenyl Benzoate Chemistry for Rapid and Selective Acylation of Intracellular Natural Proteins
Y. Takaoka, Y. Nishikawa, Y. Hashimoto, K. Sasaki, I. Hamachi*
Chem. Sci., 6, 3217 - 3224 (2015)
214. Chemically Reactive Supramolecular Hydrogel Coupled with a Signal Amplification System for Enhanced Analyte Sensitivity
T. Yoshii, S. Onogi, H. Shigemitsu, I. Hamachi*
J. Am. Chem. Soc., 137, 3360-3365 (2015)
213. Extended Affinity-guided DMAP Chemistry with Finely-tuned Acyl Donor for Intracellular FKBP12 Labeling
Z. Song, Y. Takaoka, Y. Kioi, K. Komatsu, T. Tamura, T. Miki, I. Hamachi*
Chem. Lett., 44, 333-335 (2015)
212. Rapid and Quantitative Fluorescence Detection of Pathogenic Spore-forming Bacteria Using a Xanthene-Zn(II) Complex Chemosensor
P. Tiposoth, S. Khamsakhon, N. Ketsub, T. Pongtharangkul, I. Takashima, A. Ojida, I. Hamachi, J. Wongkongkatep*
Sensors and Actuators B, 209, 606-612 (2015)
211. Ligand-Directed Tosyl Chemistry for Selective Native Protein Labeling In Vitro, In Cells, and In Vivo
S. Tsukiji, I. Hamachi*
Methods in Mol. Biol., 1266, 243-263 (2015)
210. Development of AND Logic Gate-type Fluorescent Probe for Ratiometric Imaging of Autolysosome in Cell Autophagy
I. Takashima, R. Kawagoe, I. Hamachi, A. Ojida*
Chem. -A Euro. J., 21, 2038-2044 (2015)
209. Labeling Proteins by Affinity-guided DMAP Chemistry
T. Tamura, I. Hamachi*
Methods in Mol. Biol., 1266, 229-242 (2015)
208. Intracellular Protein-responsive Supramolecules:Protein Sensing and In-cell Construction of Inhibitor Assay System
T. Yoshii, K. Mizusawa, Y. Takaoka, I. Hamachi*
J. Am. Chem. Soc., 136, 16635-16642 (2014)
207. Recent Progress in Design of Protein-based Fluorescent Biosensors and Their Cellular Applications
T. Tamura, I. Hamachi*
ACS Chemical Biology, 9, 2708-2717 (2014)
206. Live Cell Off-target Identification of Lapatinib Using Ligand-Directed Tosyl Chemistry
K. Yamaura, K. Kuwata, T. Tamura, Y. Kioi, Y. Takaoka, S. Kiyonaka, I. Hamachi*
Chem. Commun., 50, 14097-14100
(2014)
205. LDAI-based Chemical Labeling of Intact Membrane Proteins and its Pulse-Chase Analysis under Live Cell Conditions
T. Miki, S. Fujishima, K. Komatsu, K. Kuwata, S. Kiyonaka, I. Hamachi*
Chemistry & Biology, 21, 1013-1022 (2014)
204. Two-photon Responsive Supramolecular Hydrogel for Controlling Materials Motion in Micrometer Space
T. Yoshii, M. Ikeda, I. Hamachi*
Angew. Chem. Int. Ed., 53, 7264–7267 (2014)
203. Installing Logic-gate Responses to a Variety of Biological Substances in Supramolecular Hydrogel–enzyme Hybrids
M. Ikeda, T. Tanida, T. Yoshii, K. Kurotani, S. Onogi, K. Urayama, I. Hamachi*
Nat. Chem., 6, 511-518 (2014)
202. Design of a Binuclear Ni(II)–iminodiacetic Acid (IDA) Complex for Selective Recognition and Covalent Labeling of His-tag Fused Proteins
I. Takahira, H. Fuchida, S. Tabata, N. Shindo, S. Uchinomiya, I. Hamachi, A. Ojida*
Bioorg. Med. Chem. Lett., 24, 2855–2858 (2014)
201. Hoechst Tagging: a Modular Strategy to Design Synthetic Fluorescent Probes for Live-cell Nucleus Imaging
A. Nakamura, K. Takigawa, Y. Kurishita, K. Kuwata, M. Ishida, Y. Shimoda, I. Hamachi*, S. Tsukiji*
Chem. Commun., 50, 6149-6152 (2014)
200. Ligand-directed Tosyl Chemistry for in Situ Native Protein Labeling and Engineering in Living Systems: from Basic Properties to Applications
S. Tsukiji, I. Hamachi*
Curr. Opin. Chem. Biol., 21, 136-143 (2014)
199. Design of Peptide-based Bolaamphiphile Exhibiting Heat-set Hydrogelation Via Retro-Diels-Alder Reaction
R. Ochi, T. Nishida, M. Ikeda, I. Hamachi*
J. Mater. Chem. B, 2, 1464-1469 (2014)
198. Design of Ratiometric Fluorescent Probes Based on Arene-Metal Ion Contact and Their Application to Cd(II) and Hydrogen Sulfide Imaging in Living Cell
I. Takashima, M. Kinoshita, R. Kawagoe, S. Nakagawa, M. Sugimoto, I. Hamachi, A. Ojida*
Chem. -A Euro. J., 20, 2184-2192 (2014)
197. Peptide Tag/Probe Pairs Based on Coordination Chemistry for Protein Labeling
S. Uchinomiya, A. Ojida, I. Hamachi*
Inorg. Chem., 53, 1816-1823 (2014)
196. Heme Binding Mechanism of Structurally Similar Iron-Regulated Surface Determinant Near Transporter Domains of Staphylococcus aureus Exhibiting Different Affinities for Heme
Y. Moriwaki, T. Terada, J. M. M. Caaveiro, Y. Takaoka, I. Hamachi, K. Tsumoto, K. Shimizu
Biochemistry, 52, 8866-8877 (2013)
195. Selective Binding of Antimicrobial Porphyrins to the Heme-receptor IsdH-NEAT3 of Staphylococcus Aureus
N. T. Vu, Y. Moriwaki, J. M. M. Caaveiro, T. Terada, H. Tsutsumi, I. Hamachi, K. Shimizu, K. Tsumoto
Protein Sci., 22, 942-953 (2013)
194. CR1-mediated ATP Release by Human Red Blood Cells Promotes CR1 Clustering and Modulates the Immune Transfer Process
M. I. Melhorn, A. S. Brodsky, J. Estanislau, J. A. Khoory, B. Illigens, I. Hamachi, Y. Kurishita, A. D. Fraser, A. Nicholson-Weller, E. Dolmatova, H. S. Duffy, I. C. Ghiran
J. Biol. Chem., 288, 31139-31153 (2013)
193. Genetically Encoded Fluorescent Thermosensors Visualize Subcellular Thermoregulation in Living Cells
S. Kiyonaka, T. Kajimoto, R. Sakaguchi, D. Shinmi, M. Omatsu-Kanbe, H. Matsuura, H. Imamura, T. Yoshizaki, I. Hamachi, T. Morii, Y. Mori*
Nat. Methods, 10, 1232-1238 (2013)
192. Selective Labeling and Imaging of Protein Using Metal Complex
Y. Kurishita, I. Hamachi
Coordination Chemistry in Protein Cages, 223-239 (2013)
191. Disassembly-driven Turn-on Sensing of Enzyme Activity by using Substrate-based Fluorescent Nanoprobe
Y. Takaoka, Y. Fukuyama, K. Matsuo, I. Hamachi*
Chem. Lett., 42, 1426-1428 (2013)
190. Synthetic Self-Localizing Ligands That Control The Spatial Location of Proteins in Living Cells
M. Ishida, H. Watanabe, K. Takigawa, Y. Kurishita, C. Oki, A. Nakamura, I. Hamachi*, S. Tsukiji*
J. Am. Chem. Soc., 135, 12684-12689 (2013)
189. Semisynthetic Lectin-Dimethylaminopyridine Conjugates for Labeling and Profiling Glycoproteins on Live Cell Surfaces
T. Hayashi, Y. Sun, T. Tamura, K. Kuwata, Z. Song, Y. Takaoka, I. Hamachi*
J. Am. Chem. Soc., 135, 12252-12258 (2013)
188. Specific Detection and Imaging of Enzyme Activity by Signal Amplifiable Self- Assembling 19F-MRI Probes
K. Matsuo, R. Kamada, K. Mizusawa, H. Imai, Y. Takayama, M. Narazaki, T. Matsuda, Y. Takaoka, I. Hamachi*
Chem. -A Euro. J., 19, 12875-12883 (2013)
187. Fluorophore Labeling of Native FKBP12 by Ligand-directed Tosyl Chemistry Allows Detection of Its Molecular Interactions in Vitro and in Living Cells
T. Tamura, Y. Kioi, T. Miki, S. Tsukiji, I. Hamachi*
J. Am. Chem. Soc., 135, 6782-6785 (2013)
186. In-Cell Covalent Labeling of Reactive His-Tag Fused Proteins
S. Uchinomiya, H. Nonaka, S. Wakayama, A. Ojida, I. Hamachi*
Chem. Commun., 49, 5022-5024 (2013)
185. One-step Construction of Caged Carbonic Anhydrase I Using a Ligand-directed Acyl Imidazole-based Protein Labeling Method
K. Matsuo, Y. Kioi, R. Yasui, Y. Takaoka, T. Miki, S. Fujishima, I. Hamachi*
Chem. Sci., 4, 2573 - 2580 (2013)
184. Quantitative Comparison of Protein Dynamics in Live Cells and in Vitro by In-cell 19F-NMR
Y. Takaoka , Y. Kioi , A. Morito , J. Otani , K. Arita , E. Ashihara , M. Ariyoshi , H. Tochio , M. Shirakawa, I. Hamachi*
Chem. Commun., 49, 2801-2803 (2013)
183. Protein Organic Chemistry and Application for Labeling and Engineering in Live-Cell Systems
Y. Takaoka, A. Ojida, I. Hamachi
Angew. Chem. Int. Ed., 52, 4088-4106 (2013)
182. Supramolecular Hydrogels Based on Bola-amphiphilic Glycolipids Showing Color Change in Response to Glycosidases
R. Ochi, K. Kurotani, M. Ikeda, S. Kiyonaka, I. Hamachi*
Chem. Commun., 49, 2115-2117 (2012)
181. Label-Free Fluorescent Detection of Loop-Mediated Isothermal Amplification of Nucleic Acid Using Pyrophosphate-selective Xanthene-based Zn(II)-Coordination Chemosensor
E. Kittiloespaisan, A. Ojida, I. Hamachi, Y. Seetang-Nun, W. Kiatpathomchai, J. Wongkongkatep*
Chem. Lett., 41, 1666-1668 (2012)
180. Organelle-Localizable Fluorescent Chemosensors for Site-Specific Multicolor Imaging of Nucleoside Polyphosphate Dynamics in Living Cells
Y. Kurishita, T. Kohira, A. Ojida, I. Hamachi*
J. Am. Chem. Soc., 134, 18779–18789 (2012)
179. Specific Cell Surface Protein Imaging by Extended Self-assembling Fluorescent Turn-on Nanoprobes
K. Mizusawa, Y. Takaoka, I. Hamachi*
J. Am. Chem. Soc., 134, 13386-13395 (2012)
178. Heat-Induced Morphological Transformation of Supramolecular Nanostructures by Retro-Diels-Alder Reaction
M. Ikeda, R. Ochi, Y. Kurita, D. J. Pochan, I. Hamachi*
Chem. -A Euro. J., 18, 13091-13096 (2012)
177. What do we want to see and how?
Itaru Hamachi
Curr. Opin. Chem. Biol., 16, 593-594 (2012)
176. Traceless Affinity Labeling of Endogenous Proteins for Functional Analysis in Living Cells
T. Hayashi, I. Hamachi
Accounts of Chemical Research, 45, 1460-1469 (2012)
175. Bacteria Interface Pickering Emulsions Stabilized by Self-assembled Bacteria–Chitosan Network
P. Wongkongkatep, K. Manopwisedjaroen, P. Tiposoth, S. Archakunakorn, T. Pongtharangkul, M. Suphantharika, K. Honda, I. Hamachi, J. Wongkongkatep*
Langmuir, 28, 5729-5736 (2012)
174. Ligand-directed Acyl Imidazole Chemistry for Labeling of Membrane-bound Proteins on Live Cells
S. Fujishima, R. Yasui, T. Miki, A. Ojida, I. Hamachi*
J. Am. Chem. Soc., 134, 3961-3964 (2012)
173. A Supramolecular Hydrogel Containing Boronic Acid-appended Receptor for Fluorocolorimetric Sensing of Polyols with Paper Platform
M. Ikeda, K. Fukuda, T. Tanida, T. Yoshii, I. Hamachi*
Chem. Commun., 48, 2716-2718 (2012)
172. Native FKBP12 Engineering by Ligand-Directed Tosyl Chemistry: Labeling Properties and Application to Photo-Cross-Linking of Protein Complexes in Vitro and in Living Cells
T. Tamura, S. Tsukiji, I. Hamachi*
J. Am. Chem. Soc., 134, 2216-2226 (2012)
171. Phosphopeptide-Dependent Labeling of 14-3-3ζ Proteins by Fusicoccin-Based Fluorescent Probes
M. Takahashi, A. Kawamura, N. Kato, T. Nishi, I. Hamachi, J. Ohkanda*
Angew. Chem. Int. Ed., 51, 509-512 (2012)
170. Design of Multinuclear Zn(II) Complex as New Molecular Probe for Fluorescence Imaging of His-tag Fused Proteins
S. Fujishima, H. Nonaka, S. Uchinomiya, Y. A. Kawase, A. Ojida, I. Hamachi*
Chem. Commun., 48, 594-596 (2012)
169. Meter-Long and Robust Supramolecular Strands Encapsulated in Hydrogel Jackets
D. Kiriya, M. Ikeda, H. Onoe, M. Takinoue, H. Komatsu, Y. Shimoyama, I. Hamachi, S. Takeuchi*
Angew. Chem. Int. Ed., 51, 1553-1557 (2012)
168. Molecular Basis of Recognition of Antibacterial Porphyrins by Heme- Transporter IsdH-NEAT3 of Staphylococcus aureus
Y. Moriwaki, J. M. M. Caaveiro, Y. Tanaka, H. Tsutsumi, I. Hamachi, K. Tsumoto*
Biochemistry, 50, 7311-7320 (2011)
167. Chemical Cell-Surface Receptor Engineering Using Affinity-Guided, Multivalent Organocatalysts
H. Wang, Y. Koshi, D. Minato, H. Nonaka, S. Kiyonaka, Y. Mori, S. Tsukiji, I. Hamachi*
J. Am. Chem. Soc., 133, 12220-12228 (2011)
166. Systematic Study of Protein Detection Mechanism of Self-assembling 19F NMR/MRI Nanoprobes toward Rational Design and Improved Sensitivity
Y. Takaoka, K. Kiminami, K. Mizusawa, K. Matsuo, M. Narazaki, T. Matsuda, I. Hamachi*
J. Am. Chem. Soc., 133, 11725-11731 (2011)
165. Construction of a (19)F-lectin biosensor for glycoprotein imaging by using affinity-guided DMAP chemistry
Y. Sun, Y. Takaoka, S. Tsukiji, M. Narazaki, T. Matsuda, I. Hamachi*
Bioorg. Med. Chem. Lett., 21, 4393-4396 (2011)
164. Rigid Luminescent Bis-Zinc(II)–Bis-Cyclen Complexes for the Detection of Phosphate Anions and Non-Covalent Protein Labeling in Aqueous Solution
M. Bhuyan, E. Katayev, S. Stadlbauer, H. Nonaka, A. Ojida, I. Hamachi, B. König*
Eur. J. Org. Chem., 15, 2807–2817 (2011)
163. Stiff, Multistimuli-Responsive Supramolecular Hydrogel as Unique Molds for 2D/3D Microarchitectures of Live Cells
H. Komatsu, S. Tsukiji, M. Ikeda, I. Hamachi*
Chem. Asian J., 6, 2368-2375 (2011)
162. Rational Molecular Design of Stimulus-responsive Supramolecular Hydrogel Based on Dipeptides
M. Ikeda, T. Tanida, T. Yoshii, I. Hamachi*
Adv. Mater., 23, 2819-2822 (2011)
161. Mechanical Reinforcement of Supramolecular Hydrogel Through Incorporation of Multiple Noncovalent Interactions
H. Komatsu, M. Ikeda, I. Hamachi*
Chem. Lett., 40, 198-200 (2011)
160. Montmorillonite-Supramolecular Hydrogel Hybrid for Fluorocolorimetric Sensing of Polyamines
M. Ikeda, T. Yoshii, T. Matsui, T. Tanida, H. Komatsu, I. Hamachi*
J. Am. Chem. Soc., 133, 1670-1673 (2011)
159. Mechanisms of Chemical Protein 19F-Labeling and NMR-Based Biosensor Construction In Vitro and In Cells Using Self-Assembling Ligand-Directed Tosylate Compounds
Y. Takaoka, Y. Sun, S. Tsukiji, I. Hamachi*
Chem. Sci., 2, 511-520 (2011)
158. Supramolecular hydrogel-based protein and chemosensor array
M. Ikeda, R. Ochi, I. Hamachi
Lab on a Chip, 10, 3325-3334 (2010)
157. Rational Design of FRET-Based Ratiometric Chemosensors for in Vitro and in Cell Fluorescence Analyses of Nucleoside Polyphosphates
Y. Kurishita, T. Kohira, A. Ojida, I. Hamachi*
J. Am. Chem. Soc., 132, 13290-13299 (2010)
156. Supramolecular Hydrogel Capsule Showing Prostate Specific Antigen-responsive Function for Sensing and Targeting Prostate Cancer Cell
M. Ikeda, R. Ochi, A. Wada, I. Hamachi*
Chem. Sci., 1, 491-498 (2010)
155. Selective Covalent Labeling of Tag-Fused GPCR Proteins on Live Cell Surface with a Synthetic Probe for Their Functional Analysis
H. Nonaka, S. Fujishima, S. Uchinomiya, A. Ojida, I. Hamachi*
J. Am. Chem. Soc., 132, 9301-9309 (2010)
154. Disassembly-Driven Turn-On Fluorescent Nanoprobes for Selective Protein Detection
K. Mizusawa, Y. Ishida, Y. Takaoka, M. Miyagawa, S. Tsukiji, I. Hamachi*
J. Am. Chem. Soc., 132, 7291-7293 (2010)
153. Fluidic Supramolecular Nano- and Microfibres as Molecular Rails for Regulated Movement of Nanosubstances
S. Tamaru, M. Ikeda, Y. Shimidzu, S. Matsumoto, S. Takeuchi, I. Hamachi*
Nat. Commun., 1, 20 (2010)
152. Thermoresponsive Fluorescent Sensor Based on Core/Shell Nanocomposite Composed of Gold Nanoparticles and Poly(N-isopropylacrylamide)
J. Wongkongkatep*, R. Ladadat, W. Lappermpunsap, P. Wongkongkatep, P. Phinyocheep, A. Ojida, I. Hamachi
Chem. Lett., 39, 184-185 (2010)
151. Development of Highly Sensitive Fluorescent Probes for Detection of Intracellular Copper(I) in Living Systems
M. Taki*, S. Iyoshi, A. Ojida, I. Hamachi, Y. Yamamoto
J. Am. Chem. Soc., 132, 5938-5939 (2010)
150. Binuclear NiII-DpaTyr Complex as a High Affinity Probe for an Aspartate Tag Tethered to Proteins
A. Ojida, S. Fujishima, K. Honda, H. Nonaka, S. Uchinomiya, I. Hamachi*
Chem. Asian J., 5, 877-886 (2010)
2000 - 2009
2000 - 2009
149. Recent Progress in Strategies for Creation of Protein-based Fluorescent Biosensors
H. Wang, E. Nakata, I. Hamachi
ChemBioChem, 10, 2560-2577 (2009)
148. FLAG-tag Selective Covalent Protein Labeling Via a Binding-induced Acyl-transfer Reaction
H. Nonaka, S. Fujishima, S. Uchinomiya, A. Ojida, I. Hamachi*
Bioorg. Med. Chem. Lett., 19, 6696-6699 (2009)
147. Molecular Characterization of Flubendiamide Sensitivity in the Lepidopterous Ryanodine Receptor Ca2+ Release Channel
K. Kato, S. Kiyonaka, Y. Sawaguchi, M. Tohnishi, T. Masaki, N. Yasokawa, Y. Mizuno, E. Mori, K. Inoue, I. Hamachi, H. Takeshima, Y. Mori*
Biochemistry, 48, 10342–10352 (2009)
146. Thin-film Assembly of Diethanolamine-based Lipidic Material as Potential Gene Carrier in Mouse Embryonic Neural Stem Cells
K. Kusumoto*, S. Yamashita, T. Nagata, T. Ido, I. Hamachi, T. Akao
J. Biomed. Mater. Res. A, 91A, 1-10 (2009)
145. Self-assembling Nano-probes Displaying Off/On 19F NMR Signals for Protein Detection and Imaging
Y. Takaoka, T. Sakamoto, S. Tsukiji, M. Narazaki, T. Matsuda, H. Tochio, M. Shirakawa, I. Hamachi*
Nat. Chem., 1, 557-561 (2009)
144. Site-Specific Covalent Labeling of His-tag Fused Proteins with a Reactive Ni(II)-NTA Probe
S. Uchinomiya, H. Nonaka, S. Fujishima, S. Tsukiji, A. Ojida, I. Hamachi*
Chem. Commun., 39, 5880-5882 (2009)
143. Real-Time Fluorescence Monitoring of GSK3-Catalyzed Phosphoryation by Use of a BODIPY-Based Zn(II)-Dpa Chemosensor
T. Sakamoto, M. Inoue, A. Ojida, I. Hamachi*
Bioorg. Med. Chem. Lett., 19, 4175-4177 (2009)
142. Quenched Ligand-Directed Tosylate Reagents for One-Step Construction of Turn-On Fluorescent Biosensors
S. Tsukiji, H. Wang, M. Miyagawa, T. Tamura, Y. Takaoka, I. Hamachi*
J. Am. Chem. Soc., 131, 9046-9054 (2009)
141. Sequence Selective Dual-Emission Detection of (i, i+1) Bis-Phosphorylated Peptide Using Diazastilbene-Type Zn(II)-Dpa Chemosensor
Y. Ishida, M. Inoue, T. Inoue, A. Ojida, I. Hamachi*
Chem. Commun., 20, 2848-2850 (2009)
140. Fluorescent BODIPY-Based Zn(II)-Complex as a Molecular Probe for Selective Detection of Neurofibrillary Tangles in the Brains of Alzheimer’s Disease Patients
A. Ojida, T. Sakamoto, M. Inoue, S. Fujishima, G. Lippens, I.Hamachi*
J. Am. Chem. Soc., 131, 6543-6548 (2009)
139. Supramolecular Hydrogel Exhibiting Four Basic Logic Gate Functions to Fine-tune Substance Release
H. Komatsu, S. Matsumoto, S. Tamaru, K. Kaneko, M. Ikeda, I. Hamachi*
J. Am. Chem. Soc., 131, 5580-5585 (2009)
138. Selective and Direct Inhibition of TRPC3 Channels Underlies Biological Activities of a Pyrazole Compound
S. Kiyonaka, K. Kato, M. Nishida, K. Mio, T. Numaga, Y. Sawaguchi, T. Yoshida, M. Wakamori,E. Mori, T. Numata, M. Ishii, H. Takemoto, A. Ojida, K. Watanabe, A. Uemura, H. Kurose,T. Morii, T. Kobayashi, Y. Sata, C. Sato, I. Hamachi, Y. Mori*
Proc. Natl. Acad. Sci. USA, 106, 5400-5405 (2009)
137. Ligand-directed Tosyl Chemistry for Protein Labeling in Vivo
S. Tsukiji, M. Miyagawa, Y. Takaoka, T. Tamura, I. Hamachi*
Nat. Chem. Biol., 5, 341-343 (2009)
136. MCM-Enzyme-Supramolecular Hydrogel Hybrid as a Fluorescence Sensing Material for Poly-anions of Biological Significance
A. Wada, S. Tamaru, M. Ikeda, I. Hamachi*
J. Am. Chem. Soc., 131, 5321-5330 (2009)
135. Molecular Recognition, Fluorescence Sensing, and Biological Assay of Phosphate Anion Derivatives Using Artificial Zn(II)-Dpa Complexes
T. Sakamoto, A. Ojida, I. Hamachi*
Chem. Commun., 8, 141-152 (2009)
134. Recent progress of phosphate derivatives recognition utilizing artificial small molecular receptors in aqueous media
S. Tamaru, I. Hamachi
Structure and Bonding,「Recognition of Anions」, 129, 95-125 (2008)
133. Real-time Off/On-mode Fluorescence Assay for Enzyme Reactions Involving Nucleoside Polyphosphates by Use of a Xanthene Zn(II)-Dpa Chemosensor
T. Kohira, I. Takashima, H. Nonaka, A. Ojida, I. Hamachi*
Chem. Lett., 37, 1164-1165 (2008)
132. Fluorescence Imaging of Intracellular Cadmium Using a Dual-excitation Ratiometric Chemosensor
M. Taki*, M. Desaki, A. Ojida, T. Hirayama, I. Hamachi, Y. Yamamoto, S. Iyoshi
J. Am. Chem. Soc., 130, 12564-12565 (2008)
131. Three-dimensional Encapsulation of Live Cells by Using a Hybrid Matrix of Nanoparticles in a Supramolecular Hydrogel
M. Ikeda, S. Ueno, S. Matsumoto, Y. Shimizu, H. Komatsu, K. Kusumoto, I. Hamachi*
Chem. -A Euro. J., 14, 10808-10815 (2008)
130. Turn-on Fluorescence Sensing of Nucleside Polyphosphates Using a Xanthene-Based Zn(II) Complex Chemosensor
A. Ojida, I. Takashima, T. Kohira, H. Nonaka, I. Hamachi*
J. Am. Chem. Soc., 130, 12095-12101 (2008)
129. Mechanical Reinforcement of Supramolecular Hydrogel Comprising Artificial Glyco-lipid Through Supramolecular Copolymerization
M. Ikeda, Y. Shimizu, S. Matsumoto, H. Komatsu, S. Tamaru, T. Takigawa, I. Hamachi*
Macromol. Biosc., 8, 1019-1025 (2008)
128. Affinity Labeling-Based Introduction of a Reactive Handle for Natural Protein Modification
H. Wakabayashi, M. Miyagawa, Y. Koshi, Y. Takaoka, S. Tsukiji, I. Hamachi*
Chem. -An Asian J., 3, 1134-1139 (2008)
127. Photo Gel-sol/Sol-gel Transition and its Patterning of a Supramolecular Hydrogel as Stimuli-respnsive Biomaterials
S. Matsumoto, S. Yamaguchi, S. Ueno, H. Komatsu, M. Ikeda, K. Ishizuka, Y. Iko, K. V. Tabata, H. Aoki, S. Ito, H. Noji, I. Hamachi*
Chem. -A Euro. J., 14, 3977-3986 (2008)
126. Photo-responsive Gel Droplet as a Nano- or Pico-liter Container Comprising a Supramolecular hydrogel
S. Matsumoto, S. Yamaguchi, A. Wada, T. Matsui, M. Ikeda, I. Hamachi*
Chem. Commun., 13, 1545-1547 (2008)
125. Artificial Receptors Designed for Intracellular Delivery of Anionic Phosphate Derivatices
T. Kohira, K. Honda, A. Ojida, I. Hamachi*
ChemBioChem, 9, 698-701 (2008)
124. Thermally Responsive Supramolecular Nano-meshes for on/off Switching of the Rotary Motion of F1-ATPase at a Single Molecular Level
S. Yamaguchi, S. Matsumoto, K. Ishizuka, Y. Iko, K. V. Tabata, H. Arata, H. Fujita, H. Noji, I. Hamachi*
Chem. -A Euro. J., 14, 1891-1896 (2008)
123. Ratiometric Fluorescent Biosensor for Real-time and Label-free Monitoring of Fine Saccharide Metabolic Pathways
E. Nakata, H. Wang, I. Hamachi*
ChemBioChem, 9, 25-28 (2008)
122. Target-Specific Chemical Acylation of Lectins by Ligand-Tethered DMAP Catalysts
Y. Koshi, E. Nakata, M. Miyagawa, S. Tsukiji, T. Ogawa, I. Hamachi*
J. Am. Chem. Soc., 130, 245-251 (2008)
121. Development of New Methods to Intruduce Unnatural Function into Native Proteins for Protein Engineering
E. Nakata, S. Tsukiji, I. Hamachi
Bull. Chem. Soc. Jpn., 80, 1268-1279 (2007)
120. Lectin Functionalizaion by Post-Photo Affinity Labeling Modification(P-PLAM)
Y. Koshi, E. Nakata, I. Hamachi
Trends in Glycoscience and Glycotechnology, 19, 121–131 (2007)
119. Non-enzymatic Covalent Protein Labeling Using a Reactive Tag
H. Nonaka, S. Tsukiji, A. Ojida, I. Hamachi*
J. Am. Chem. Soc., 129, 15777-15779 (2007)
118. Pyrene Excimer Based Dual-Emission detection of a Oligoaspartate Tag Fused Protein Using Zn(II)-DpaTyr Probe
K. Honda, S. Fujishima, A. Ojida, I. Hamachi*
ChemBioChem, 8, 1370-1372 (2007)
117. Design of a Hybrid Biosensor for Enhanced Phosphopeptide Recognition Based on a Phosphoprotein Binding Domain Coupled with a Fluorescent Chemosensor
T. Anai, E. Nakata, Y. Koshi, A. Ojida, I. Hamachi*
J. Am. Chem. Soc., 129, 6232-6239 (2007)
116. Design and Synthesis of Bis(Zn(II)-dipicolylamine)-based Fluorescent Artificial Chemosensors for Phosphorylated Proteins/peptides
A. Ojida, I. Hamachi
Bull. Chem. Soc. Jpn., 1,35-46 (2006)
115. Design of Dual-Emission Chemosensors for Ratiometric Detection of ATP Derivatives
A. Ojida, Y. Miyahara, J. Wongkongkatep, S. Tamaru, K. Sada, I. Hamachi*
Chem. Asian J., 1, 555-563 (2006)
114. Ratiometric Fluorescence Detection of a Tag Fused Protein using the Dual-emission Artificial Molecular Probe
K. Honda, E. Nakata, A. Ojida, I. Hamachi*
Chem. Commun., 38, 4024-4026 (2006)
113. A Fluorescent Lectin Array Using Supramolecular Hydrogel for Simple Detection and Pattern Profiling for Various Glyco-conjugates
Y. Koshi, E. Nakata, H. Yamane, I. Hamachi*
J. Am. Chem. Soc., 128, 10413-10422 (2006)
112. Bis(Dpa-Zn(II)) Appended Xanthone: Excitation Ratiometric Chemosensor for Phosphate Anion Derivatives Based on Anion-Induced Rearrangement of Coordination Chemistry
A. Ojida, H. Nonaka, Y. Miyahara, S. Tamaru, K. Sada, I. Hamachi*
Angew. Chem. Int. Ed., 45, 5518-5521 (2006)
111. Oligo-Asp Tag/Zn(II)-Complex Probe as a New Pair for Labeling and Fluorescence Imaging of Proteins
A. Ojida, K. Honda, D. Shinmi, S. Kiyonaka, Y. Mori, I. Hamachi*
J. Am. Chem. Soc., 128, 10452-10459 (2006)
110. Identification of a New Class of Low Molecular Weight Antagonists against the Chemokine Receptor CXCR4 Having the Dipicolylamine-Zinc(II) Complex Structure
H. Tamamura*, A. Ojida, T. Ogawa, H. Tsutsumi, H. Masuno, H. Nakashima, N. Yamamoto, I. Hamachi, N. Fujii*
J. Med. Chem., 49, 3412-3415 (2006)
109. One-pot and Sequential Organic Chemistry on an Enzyme Surface to Tether a Fluorescent Probe at the Proximity of the Active Site with Restoring Enzyme Activity
Y. Takaoka, H. Tsutsumi, N. Kasagi, E. Nakata, I. Hamachi*
J. Am. Chem. Soc., 128, 3273-3280 (2006)
108. Effective Disruption of Phosphoprotein-Protein Surface Interaction Using Zn(II) Dipicolylamine-Based Artificial Receptors via Two-Point Interaction
A. Ojida, M. Inoue, Y. Mito-oka, H. Tsutsumi, K. Ssda, I. Hamachi*
J. Am. Chem. Soc., 128, 2052-2058 (2006)
107. Label-Free, Real-Time Glycosyltransferase Assay Based on a Fluorescent Artificial Chemosensor
J. Wongkongkatep, Y. Miyahara, A. Ojida, I. Hamachi*
Angew. Chem. Int. Ed., 45, 665-668 (2006)
106. Double-Modification of Lectin Using Two Distinct Chemistries for Fluorescent Ratiometric Sensing and Imaging Saccharides in Test Tube or in Cell
E. Nakata, Y. Koshi, E. Koga, Y. Katayama, I. Hamachi*
J. Am. Chem. Soc., 127, 13253-13261 (2005)
105. Globular Self-aggregates Formed with A Urea-functionalized Resorcinarene Derivative in Chloroform
O. Hayashida*, S. Matsumoto, I. Hamachi*
Chem. Lett., 34, 1276-1277 (2005)
104. Three Distinct Reading-out Modes for Enzyme Acticity can be Operated in Semi-wet Supramolecular Hydrogel
S. Tamaru, S. Kiyonaka, I. Hamachi*
Chem. -A Euro. J., 11, 7294-7304 (2005)
103. Cooperation between Artificial Receptor and Supramolecular Hydrogel for Sensing and Discriminating Phosphate Derivatives
S. Yamaguchi, I. Yoshimura, T. Kohira, S. Tamaru, I. Hamachi*
J. Am. Chem. Soc., 127, 11835-11841 (2005)
102. Luminescent Saccharide Biosensor by Using Lanthanide-Bound Lectin Labeled with Fluorescein
Y. Koshi, E. Nakata, I. Hamachi*
ChemBioChem, 6, 1349-1352 (2005)
101. Simple and Practical Semi-wet Protein/Peptide Array Utilizing a Micelle-mixed Agarose Hydrogel
S. Tamaru, S. Yamaguchi, I. Hamachi*
Chem. Lett., 34, 294-295 (2005)
100. Suzuki Coupling for Protein Modification
A. Ojida, H. Tsutsumi, N. Kasagi, I. Hamachi*
Tetrahedoron Lett., 46, 3301-3305 (2005)
99. Synthesis and Guest-binding Study of Polytopic Multi(cyclophane) Hosts
O. Hayashida*, Y. Takaoka, I. Hamachi*
Tetrahedoron Lett., 46, 6589-6592 (2005)
98. Cyclophane-lectin Conjugates as A New Class of Water-soluble Host
O. Hayashida*, I. Hamachi
J. Incl. Phenom. Macro. Chem., 53, 57-61 (2005)
97. Preparation and Unique Circular Dichroism Phenomena of Urea-Functionalized Self-Folding Resorcinarenes Bearing Chiral Termini through Asymmetric Hydrogen Bonding Belts
O. Hayashida*, J. Ito, S. Matsumoto, I. Hamachi
Org. Biomol. Chem., 3, 654-660 (2005)
96. pH-Responsive Shrinkage/Swelling of Supramolecular Hydrogel Comprised of Two Components of Amphiphilic Small Molecules
S-L. Zhou, S. Matsumoto, H-D Tian, H. Yamane, A. Ojida, S. Kiyonaka, I. Hamachi*
Chem. -A Euro. J., 11, 1130-1136 (2005)
95. Recognition and Fluorescence Sensing of Specific Amino Acid Residue on Protein Surface Using Designed Molecules
A. Ojida, Y. Miyahara, T. Kohira, I. Hamachi
Biopolymers-Peptide Science, 76, 177-184 (2004)
94. Molecular Recognition in a Supramolecular Hydrogel to Afford a Semi-wet Sensor Chip
I. Yoshimura, Y. Miyahara, N. Kasagi, H. Yamane, A. Ojida, I. Hamachi*
J. Am. Chem. Soc., 126, 12204-12205 (2004)
93. Phosphoprotein-Selective Recognition and Staining in SDS-PAGE by Bis-Zn(II)-dipycolylamine-Appended Anthracene
A. Ojida, T. Kohira, I. Hamachi*
Chem. Lett., 33, 1024-1025 (2004)
92. Urea-functionalized Resorcinarenes: Preparation, Self-folding, and Their CD Phenomena Caused by Chiral Urea Termini through Intramolecular Hydrogen Bonding Interactions
O. Hayashida*, J. Ito, S. Matsumoto, I. Hamachi*
Chem. Lett., 33, 994-995 (2004)
91. Fluorophore Appended Saccharide Cyclophane: Self-Association, Fluorescent Properties, Heterodimers with Cyclodextrins, and Cross-Linking Behavior with Peanut Agglutinin of Dansyl-Modified Saccharide Cyclophane
O. Hayashida*, I. Hamachi*
J. Org. Chem., 69, 3509-3516 (2004)
90. A FRET Study of Guest Delivery to Concanavaline A by Supramolecular Hosts Composed of an Adamantyl-appended Cyclophane and Saccharide-branched Cyclodextrins
O. Hayashida*, I. Hamachi*
Chem. Lett., 33, 548-549 (2004)
89. Molecular Recognition and Fluorescence Sensing toward mono-Phosphorylated Peptides in Aqueous Solution by bis(Zn(II)-dipicolylamine)-based Artificial Receptors
A. Ojida, Y. Mito-oka, K. Sada, I. Hamachi*
J. Am. Chem. Soc., 126, 2454-2463 (2004)
88. Coupling a Natural Receptor Protein with an Artificial Receptor to Afford a Semisynthetic Fluorescent Biosensor
E. Nakata, T. Nagase, S. Shinkai, I. Hamachi*
J. Am. Chem. Soc., 126, 490-495 (2004)
87. Semi-wet Peptide/Protein Array Using Supramolecular Hydrogel
S. Kiyonaka, K. Sada, I. Yoshimura, S. Shinkai, N. Kato, I. Hamachi*
Nat. Mater., 3, 57-64 (2004)
86. Cross-Linking Strategy for Molecular Recognition and Fluorescent Sending of a Multi-phosphorylated Peptide in Aqueous Solution
A. Ojida, M. Inoue, Y. Mito-oka, I. Hamachi*
J. Am. Chem. Soc., 125, 10184-10185 (2003)
85. Construction of Artifical Signal Transducers on a Lectin Surface by Post-Photoaffinity-Labeling Modification for Fluorescent Sccharide Biosensors
T. Nagase, E. Nakata, S. Shinkai, I. Hamachi*
Chem. -A Euro. J., 9, 3660-3669 (2003)
84. New Supramolecular Approach for Saccharide-directed Chemical Modification of Concanavalin A
O. Hayashida*, I. Hamachi*
Chem. Lett., 32, 632-633 (2003)
83. Molecular Recognition by Supramolecular Hosts Composed of an Adamanthyl-appended Macrocycle with Cyclodextrins in Water
O. Hayashida*, I. Hamachi*
Chem. Lett., 32, 288-289 (2003)
82. pH-Responsive Phase Transition of Supramolecular Hydrogel Consisting of Glycosylated Amino Acetate and Carboxylic Acid Derivative
S. Kiyonaka, S-L. Zhou, I. Hamachi*
Supramol. Chem., 15, 521-528 (2003)
81. Combinatorial Library of Low Molecular Weight Organo-and Hydrogelators Based on Glycosylated Amino Acid Derivatives by Solid Phase Synthesis
S. Kiyonaka, S. Shinkai, I. Hamachi*
Chem. -A Euro. J., 9, 976-983 (2003)
80. Caged RNase: Photoactivation of the Enzyme from Perfect Off-state by Site-specific Incorporation of 2-Nitrobenzyl Moiety
T. Hiraoka, I. Hamachi*
Bioorg. Med. Chem. Lett., 13, 13-15 (2003)
79. Semisynthetic Hemoproteins Using Cofactor Engineering
S. Tsukiji, I. Hamachi
Supramol.Chem., 14, 133-142 (2002)
78. Site-specific Discrimination by Cyanovirin-N for alfa-Linked Trisaccharides Comprising the Three Arms of Man8 and Man9
C. A. Bewley*, S. Kiyonaka, I. Hamachi
J. Mol. Biol., 322, 881-889 (2002)
77. Efficient Fluorescent ATP-sensing Based on Coordination Chemistry under Aqueous Neutral Conditions
A. Ojida, S-K Parkm Y. Mito-oka, I. Hamachi*
Tetrahedron Lett., 43, 6193-6195 (2002)
76. First Thermally Responsive Supramolecular Polymer Based on Glycosylated Amino Acid
S. Kiyonaka, K. Sugiyasu, S. Shinkai, I. Hamachi*
J. Am. Chem. Soc., 124, 10954-10955 (2002)
75. First Artificial Receptors and Chemosensors toward Phosphorylated Peptide in Aqueous Solution
A. Ojida, Y. Mito-oka, M. Inoue, I. Hamachi*
J. Am. Chem. Soc., 124, 6256-6258 (2002)
74. Incorporation of Artificial Receptors into a Protein/Peptide Surface: a Strategy for On/Off Type of Switching of Semisynthetic Enzymes
I. Hamachi, J. Watanabe, R. Eboshi, T. Hiraoka, S. Shinkai
Biopolymers 55, 459-468 (2001)
73. Supramolecular Construction of Covalently and Noncovalently-linked Photoinduced Electron Transfer Systems in Myoglobin Scaffold
H. Takashima, Y-Z. Hu, K. Sano, S. , S. Shinkai, S. Oishi, I. Hamachi*
Electorchemistry, 69, 942-945 (2001)
72. Zn(II) Dipicolylamine-based Artificial Receptor as A New Entry for Surface Recognition of a-Helical Peptides in Aqueous Solution
Y. Mito-oka, S. Tsukiji, T. Hiraoka, N. Kasagi, S. Shinkai, I. Hamachi*
Tetrahedron Lett., 42, 7059-7062 (2001)
71. Solid-phase Lipid Synthesis (SPLS)-2: Incidental Discovery of Organogelators Based on Artificial Glycolipids
I. Hamachi*, S. Kiyonaka, S. Shinkai
Tetrahedron Lett., 42, 6141-6145 (2001)
70. Post-Photoaffinity Labeling Modification Using Aldehyde Chemistry to Produce a Fluorescent Lectin toward Sacchariide-Biosensors
T. Nagase, S. Shinkai, I. Hamachi*
Chem. Commun., 229-230 (2001)
69. Pd(en) as a Sequence-Selective Molecular Pinch for a-Helical Peptides
I. Hamachi*, N. Kasagi, S. Kiyonaka, T. Nagase, Y. Mito-oka, S. Shinkai
Chem. Lett., 16-17 (2001)
68. A General Semisynthetic Method for Fluorescent Saccharide-Biosensors Based on a Lectin
I. Hamachi*, T. Nagase, S. Shinkai
J. Am. Chem. Soc., 122, 12065-12066 (2000)
67. Solid Phase Lipid Synthesis (SPLS) for Construction of an Artificial Glycolipid Library
I. Hamachi*, S. Kiyonaka, S. Shinkai
Chem. Commun., 1281-1282 (2000)
66. Cyclodextrin-Appended Myoglobin as a Tool for Construction of a Donor-Sensitizer-Acceptor Triad on a Protein Surface
I. Hamachi*, H. Takashima, Y-Z. Hu, S. Shinkai, S. Oishi
Chem. Commun., 1127-1128 (2000)
65. Direct Comparison of Electron Transfer Properties of Two Distinct Semisynthetic Triads with Non-Protein Based Triad: Unambiguous Experimental Evidences on Protein Matrix Effects
Y-Z. Hu, H. Takashima, S. Tsukiji, S. Shinkai, T. Nagamune, S. Oishi, I. Hamachi*
Chem. -A Euro. J., 6, 1907-1916 (2000)
64. Novel Saccharide-Induced Conformational Changes in a Boronic Acid-appended Poly(L-Lysine) as Detected by Circular Dichroism and Fluorescence
H. Kobayashi, K. Nakashima, E. Ohshima, Y. Hisaeda, I. Hamachi, S. Shinkai*
J. Chem. Soc., Perkin Trans. 2, 5, 997-1002 (2000)
63. Guest-Induced Umpolung on a Protein Surface: A Strategy for Regulation of Enzymatic Activity
I. Hamachi*, R. Eboshi, J. Watanabe, S. Shinkai
J. Am. Chem. Soc., 122, 4530-4531 (2000)
62. Coupling Covalent and Noncovalent Electron Transfer in a Catename-Type Donor-Sensitizer-Acceptor Triad
Y-Z. Hu, S. Tsukiji, S. Shinkai, S. Oishi, H. Duerr, I. Hamachi*
Chem. Lett., 5, 442-443 (2000)
61. The Synthesis of a Reconstituted C60-Modified Protein
H. Murakami, Y. Okusa, S. Kiyonaka, I. Hamachi, S. Shinkai, N. Nakashima
Chem. Lett., 1, 46-47 (2000)
60. Construction of Artificial Photosynthetic Reaction Centers on a Protein Surface: Vectorial, Multistep, and Proton-Coupled Electron Transfer for Long-Lived Charge Separation
Y-Z. Hu, S. Tsukiji, S. Shinkai, S. Oishi, I. Hamachi
J. Am. Chem. Soc., 122, 241-253 (2000)
59. Incorporation of Artificial Receptors into a Protein/Peptide Surface: A Strategy for on/off Type of Switching of Semisynthetic Enzymes
I. Hamachi, J.-I. Watanabe, R. Eboshi, T. Hiraoka, S. Shinkai
Biopolymers-Peptide Science Section, 55, 459-468 (2000)
1990 - 1999
1990 - 1999
58. Chemical Modification of Structures and Functions of Proteins by Cofactor Reconstitution Method
I. Hamachi, S. Shinkai
Eur. J. Org. Chem., 3, 539-549 (1999)
57. Ru(bpy)3-Based Artificial Receptors toward a Protein Surface: Selective Binding and Efficient Photoreduction of Cytochrome c
H. Takashima, S. Shinkai, I. Hamachi
Chem. Commun., 23, 2345-2346 (1999)
56. Metal-Induced Conformational Changes in Calix[n]arenes Can Control the Electron-Transfer Efficiency between Porphyrin and [60]Fullerene in an On-Off Manner
M. Kawaguchi, A. Ikeda, I. Hamachi, S. Shinkai
Tetrahedron. Lett., 40, 8245-8249 (1999)
55. Electron Transfer from Zn-Protoporphyrin IX to Ruthenium Ammine Attached at His63 of Reconstituted Cytochrome b562
I. Hamachi, H. Takashima, S. Tsukiji, S. Shinkai, T. Nagamune, S. Oishi
Chem. Lett., 7, 551-552 (1999)
54. Direct Observation of the Ferric-Porphyrin Cation Radical as an Intermediate in the Phototriggered Oxidation of Ferric- to Ferryl-Heme Tethered Ru(bpy)3 in Reconstituted Myoglobin
I. Hamachi, S. Tsukiji, S. Shinkai, S. Oishi
J. Am. Chem. Soc., 121, 5500-5506 (1999)
53. A Convenient Synthesis of a Ru(bpy)3-Based Catenane-Type Triad and Its Incorporation into a Protein Scaffold
Y-Z. Hu, S. Tsukiji, S. Shinkai, I. Hamachi
Chem. Lett., 6, 517-518 (1999)
52. Single- or Dual-Mode Switching of Semisynthetic Ribonuclease S' with an Iminodiacetic Acid Moiety in Response to the Copper(II) Concentration
I. Hamachi, Y. Yamada, T. Matsugi, S. Shinkai
Chem. -A Euro. J., 5, 1503-1511 (1999)
51. Design and Semisynthesis of Spermine-Sensitive Ribonuclease S'
I. Hamachi, Y. Yamada, R. Eboshi, T. Hiraoka, S. Shinkai
Bioorg. Med. Chem. Lett., 9, 1215-1218 (1999)
50. Facile Preparation of Robust Organic Gels by Cross-Link of a Sugar-Integrated Gelator by Toluene-2,4-diisocyanate
K. Inoue, Y. Ono, Y. Kanekiyo, S. Kiyonaka, I. Hamachi, S. Shinkai
Chem. Lett., 3, 225-226 (1999)
49. A Boronic Acid-diol Interaction Is Useful for Chiroselective Transcription of the Sugar Structure to the Delta- versus Lamda-[Co(III)(bpy)3]3+ Ratio
T. Mizuno, Takeuchi, I. Hamachi, K. Nakashima, S. Shinkai
J. Chem. Soc., Perkin Trans. 2, 10, 2281-2288 (1998)
48. Design and Semisynthesis of Photo-Active Myoglobin-Bearing Ruthenium Tris(2,2-bipyridine) Using Cofactor-Reconstitution
I. Hamachi, S. Tanaka, S. Tsukiji, S. Shinkai, S. Oishi
Inorg. Chem., 37, 4380-4388 (1998)
47. Photoswiching of the Enzymatic Activity of Semisynthetic Ribonuclease S' Bearing Phenylazophenylalanine at a Specific Site
I. Hamachi, T. Hiraoka, Y. Yamada, S. Shinkai
Chem. Lett., 6, 537-538 (1998)
46. Pyrenylboronic Acids as a Novel Entry for Photochemical DNA Cleavage: Diradical-Forming Pyrene-1,6-diyldiboronic Acid Mimics the Cleavage Mechanism of Enediyne Antitumor Antibiotics
H. Suenaga, K. Nakashima, T. Mizuno, M. Takeuchi, I. Hamachi, S. Shinkai
J. Chem. Soc., Perkin Trans. 1, 7, 1263-1267 (1998)
45. Design and Synthesis of a Transition Metal Responsive Semisynthetic Myoglobin-Bearing Iminodiacetic Acid Moiety
I. Hamachi, T. Matsugi, K. Wakigawa, S. Shinkai
Inorg. Chem., 37, 1592-1597 (1998)
44. Incorporation of an Artificial Receptor into a Native Protein: New Strategy for the Design of Semisynthetic Enzymes with Allosteric Properties
I. Hamachi, T. Nagase, Y. Tajiri, S. Shinkai
Bioconjugate Chem., 8, 862-868 (1997)
43. Protein Engineering Using Molecular Assembly: Functional Conversion of Cytochrome c via Noncovalent Interactions
I. Hamachi, A. Fujita, T. Kunitake
J. Am. Chem. Soc., 119, 9096-9102 (1997)
42. Chiroselective Transcription of the Sugar Structure to D- or L-[CoIII(bpy)3]3+ Using a Boronic Acid-Sugar Template Interaction
T. Mizuno, M. Takeuchi, I. Hamachi, K. Nakashima, S. Shinkai
Chem. Commun., 18, 1793-1794 (1997)
41. Photocontrol of the Redox State of Ruthenium-Tris(bipyridine)-Appended Cytochrome b562
I. Hamachi, S. Tanaka, S. Tsukiji, S. Shinkai, M. Shimizu, T. Nagamune
Chem. Commun., 18, 1735-1736 (1997)
40. Design and Synthesis of Sugar-Responsive Semiartificial Myoglobin Triggered by Modulation of Apoprotein-Cofactor Interactions
I. Hamachi, Y. Tajiri, T. Nagase, S. Shinkai
Chem. -A Euro. J., 3, 1025-1031 (1997)
39. Pyrenylboronic Acid as a Novel Entry for Photochemical DNA Cleavage
H. Suenaga, K. Nakashima, I. Hamachi, S. Shinkai
Tetrahedron Lett., 38, 2479-2482 (1997)
38. A Novel Sugar Sensing System Designed with a Cooperative Action of a Boronic-Acid-Appended Zinc Porphyrin and a 3-Pyridylboronic Acid Axial Ligand
M. Takeuchi, H. Kijima, I. Hamachi, S. Shinkai
Bull. Chem. Soc. Jpn., 70, 699-705 (1997)
37. Sugar-Induced Chiral Orientation of Boronic-Acid-Appended Amphiphile Clusters Formed in the Dipalmitoylphosphatidylcholine (DPPC) Membrane
T. Kimura, M. Takeuchi, I. Hamachi, S. Shinkai
Israel J. Chem., 36, 379-388 (1996)
36. Transition-Metals Facilitated Electron Transfer of Semisynthetic Myoglobin Bearing Bis(iminodiacetic Acid) Moiety
I. Hamachi, T. Matsugi, S. Shinkai
Tetrahedron Lett., 37, 9233-9236 (1996)
35. Sugar-Enhanced Aniline Hydroxylase Activity of Semisynthetic Myoglobins Possessing m-Dihydroxyphenylalanine
I. Hamachi, T. Nagase, Y. Tajiri, S. Shinkai
Chem. Commun., 18, 2205-2206 (1996)
34. Efficient Photogeneration of Oxidizing (Compound II-like) Species of Semisynthetic Myoglobin Appending Ruthenium Tris(2,2'-bipyridine)
I. Hamachi, S. Tsukiji, S. Tanaka, S. Shinkai
Chem. Lett., 9, 751-752 (1996)
33. Facilitated Photoreduction of Ruthenium Bis(4'-methylterpyridine) Pendant Myoglobin
I. Hamachi, T. Matsugi, S. Tanaka, S. Shinkai
Bull. Chem. Soc. Jpn., 69, 1657-1661 (1996)
32. Aniline-Hydroxylase Activity of Myoglobin by Coupling with a Membrane-Bound Electron Transport System
I. Hamachi, A. Fujita, T. Kunitake
Chem. Lett., 8, 657-658 (1995)
31. Peroxidase Activity of Cytochrome c Generated by Phenylboronic Acid Modification
I. Hamachi, O. Kimura, H. Takeshita, S. Shinkai
Chem. Lett., 7, 529-530 (1995)
30. X-ray Crystallographic Studies of a Mn(II)-Bridged Biscalix[4]arene with a Large Inner Cavity
H. Iki, H. Tsuzuki, H. Kijima, I. Hamachi, S. Shinkai
Supramol. Chem., 4, 223-228 (1995)
29. Enhanced N-Demethylase Activity of Cytochrome c Bound to a Phosphate-Bearing Synthetic Bilayer Membrane
I. Hamachi, A. Fujita, T. Kunitake
J. Am. Chem. Soc., 116, 8811-8812 (1994)
28. Novel Chemical Modification of Myoglobin by an Alcohol-Responsive Phenylboronic Acid Function
T. Nagasaki, O. Kimura, I. Hamachi, S. Shinkai
Chem. Lett., 10, 1945-1948 (1994)
27. Sugar-Responsive Semisynthetic Myoglobin Bearing Phenylboronic Acid Groups as Recognition Sites
I. Hamachi, Y. Tajiri, S. Shinkai
J. Am. Chem. Soc., 116, 7437-7438 (1994)
26. Enhanced Peroxidase Activity of Cytochrome c by Phosphate Bilayer Membrane
A. Fujita, H. Senzu, T. Kunitake, I. Hamachi
Chem. Lett., 7, 1219-1232 (1994)
25. Sugar Sensing Utilizing Aggregation Properties of Boronic-Acid-Appended Porphyrins and Metalloporphyrins
H. Murakami, T. Nagasaki, I. Hamachi, S. Shinkai
J. Chem. Soc. Perkin Trans. 2, 975-981 (1994)
24. Self-Sufficient Electron Injection from NADH to the Active Center of Flavin-Pendant Myoglobin
I. Hamachi, K. Nomoto, S. Tanaka, Y. Tajiri, S. Shinkai
Chem. Lett., 6, 1139-1142 (1994)
23. Synthesis, Metal-Binding Properties and Polypeptide Solubilization of 'Crowned' Arborols
T. Nagasaki, O. Kimura, M. Ukon, S. Arimori, I. Hamachi, S. Shinkai
J. Chem. Soc. Perkin Trans. 1, 75-81 (1994)
22. Sugar-Facilitated Incorporation of a Heme Cofactor Bearing Phenylboronic Acid Groups into Apomyoglobin
I. Hamachi, Y. Tajiri, H. Murakami, S. Shinkai
Chem. Lett., 3, 575-578 (1994)
21. Sugar Sensing Utilizing Aggregation Properties of a Boronic-Acid-Appended Porphyrin
H. Murakami, T. Nagasaki, I. Hamachi, S. Shinkai
Tetrahedron Lett., 34, 6273-6276 (1993)
20. Light-Driven Activation of Reconstituted Myoglobin with a Ruthenium Tris(2,2'-bipyridine) Pendant
I. Hamachi, S. Tanaka, S. Shinkai
J. Am. Chem. Soc., 115, 10458-10459 (1993)
19. Energy Transfer from Zinc-Myoglobin to a Cyanine Dye Facilitated by Their Simultaneous Binding to a Phosphate Bilayer Membrane
I. Hamachi, H. Fujimura, T. Kunitake
Chem. Lett., 22, 1551-1554 (1993)
18. Reconstitution of Myoglobin with a Heme Cofactor Bearing a Ruthenium Tris(2,2'-bipyridine) Pendant
I. Hamachi, S. Tanaka, S. Shinkai
Chem. Lett., 22, 1417-1420 (1993)
17. Lipid Anchored Myoglobin 2. Effect of the Anchor Structure on Membrane Binding
I. Hamachi, S. Higuchi, K. Nakamura, H. Fujimura, T. Kunitake
Chem. Lett., 22, 1175-1178 (1993)
16. Anisotropic Incorporation of Lipid-Anchored Myoglobin into a Phospholipid Bilayer Membrane
I. Hamachi, K. Nakamura, A. Fujita, T. Kunitake
J. Am. Chem. Soc., 115, 4966-4970 (1993)
15. Simultaneous Fixation of Orientation of Myoglobin and Metalloporphyrins by Synthetic Bilayer Membrane
I. Hamachi, S. Noda, H. Iwasaki, T. Kunitake
Proc. Japan Acad., 68, 47-50 (1992)
14. Functional Conversion of Myoglobin Bound to Synthetic Bilayer Membranes: From Dioxygen Storage Protein to Redox Enzyme
I. Hamachi, S. Noda, T. Kunitake
J. Am. Chem. Soc., 113, 9625-9630 (1991)
13. Immobilization of Myoglobin in a Multilayer Film of Two-Dimensional Polymer Network
I. Hamachi, H. Fujimura, T. Kunitake,
Chem. Lett., 20, 2227-2230 (1991)
12. A Novel Transmembrane Electron Channel Containing Flavin Units
Y. Kobuke, M. Yamanishi, I. Hamachi, H. Kagawa, H. Ogoshi
J. Chem. Soc., Chem. Commun., 13, 895-897 (1991)
11. Oriented Intercalation of Myoglobin into Multilayered Films of Synthetic Bilayer Membranes
I. Hamachi, T. Honda, S. Noda, T. Kunitake
Chem. Lett., 20, 1121-1124 (1991)
10. Layered Arrangement of Oriented Myoglobins in Cast Films of a Phosphate Bilayer Membrane
I. Hamachi, S. Noda, T. Kunitake
J. Am. Chem. Soc., 112, 6744-6745 (1990)
1980 - 1989
1980 - 1989
9. Coupled Electron-Proton Transport in Flavolipid Functionalized Liposome
Y. Kobuke, I. Hamachi
J. Chem. Soc., Chem. Commun., 18, 1300-1302 (1989)
8. Synthesis of Side-Chain Derivatives of 2,2'-Bipyridine
L. D. Ciana, I. Hamachi, T. J. Meyer
J. Org. Chem., 54, 1731-1735 (1989)
7. Artificial Flavolipid. Its Synthesis, Incorporation into Liposomal Membrane, Electron Transport, and Successful Control of Transport Rate
I. Tabushi, I. Hamachi, Y. Kobuke
J. Chem. Soc. Perkin Trans. 1, 383-390 (1989)
6. Facilitated Electron Transfer from NADH to Flavolipid Bound in Ammonium Bilayer
I. Hamachi, Y. Kobuke
J. Chem. Soc., Chem. Commun., 2, 130-131 (1989)
5. Efficient Electron Flux Conversion from Strongly Hydrophilic NADH Model in the Transmembrane Electron Transfer by Flavolipid
I. Hamachi, Y. Kobuke, I. Tabushi
Bull. Chem. Soc. Jpn., 61, 3613-3618 (1988)
4. Control of Electron Transport by Thermally Induced Phase Transition of Liposomal Membrane
I. Tabushi, I. Hamachi, Y. Kobuke
Tetrahedron Lett., 28, 5899-5902 (1987)
3. Single Wall Bilayer Liposome Functionalized with the Artificial Flavolipid (II): Its Efficient Electron Flux Conversion from NADH Model of an Appropriate Structure in the Transmembrane Electron Transfer
I. Tabushi, I. Hamachi
Tetrahedron Lett., 28, 3363-3366 (1987)
2. First Member of Artificial Flavolipid Family, Its Synthesis and Incorporation into Arificial Liposomes
I. Tabushi, I. Hamachi
Tetrahedron Lett., 27, 5401-5404 (1986)
1. Erythroselectivity in Addition of g-Substituted Allylsilanes to Aldehydes in the Presence of Titanium Chloride
T. Hayashi, K. Kabeta, I. Hamachi, M. Kumada
Tetrahedron Lett., 24, 2865-2868 (1983)
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